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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

2-Chloro-6-fluoroanisole Manufacturer/High quality/Best price/In stock

Cas:53145-38-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-Chloro-6-Fluoroanisole

Cas:53145-38-3

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent out in 24 hours after payment.Tracking number available 2) Secure and disc

2-Chloro-6-fluoroanisole CAS:53145-38-3

Cas:53145-38-3

Min.Order:1 Kilogram

FOB Price: $150.0 / 200.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - 2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:1 Gram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-Chloro-6-fluoroanisole cas no. 53145-38-3 98%

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

2-Chloro-6-Fluoroamisole

Cas:53145-38-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high qualityAppearance:white crystalline powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

2-Fluoro-4-methoxyphenylacetic acid

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

2-Chloro-6-Fluoroanisole

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen AmoyChem Co.,Ltd

Amoychem is committed to providing the top-quality chemical products and services Internationally. We offer our customers with friendly, professional service and reliable, high performance products that have been manufactured according to the accredi

2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Fandachem Co.,Ltd

2-Chloro-6-fluoroanisole cas 53145-38-3Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

2-Chloro-6-fluoroanisole cas 53145-38-3

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low price Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

2-Chloro-6-fluoroanisole 53145-38-3

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shenzhen Foris Technology Co. LTD

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

2-Chloro-6-fluoroanisole 53145-38-3

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Bide Pharmatech Ltd

Our mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical

2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Other

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

2-Chloro-6-fluoroanisole

Cas:53145-38-3

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Hanhong Scientific Co.,Ltd.

factory,reasonable price Appearance:detailed see specifications Storage:Store in dry, dark and ventilated place. Package:according to the clients requirement Application:pharmaceutical intermediates Transportation:by courier,air or sea Port:S

2-Chloro-6-fluoroanisole53145-38-3

Cas:53145-38-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

2-chloro-6-fluorophenol
2040-90-6

2-chloro-6-fluorophenol

methyl iodide
74-88-4

methyl iodide

1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran at 20℃; for 3h;94%
1,2-Dichloro-3-nitrobenzene
3209-22-1

1,2-Dichloro-3-nitrobenzene

1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: diisopropylamine / methanol / 5 h / 60 °C
2.1: hydrogen; 1% platinum on charcoal / toluene / 18 h / 40 °C / 3375.34 Torr / Autoclave
3.1: hydrogenchloride / water / 0.5 h / 50 °C
3.2: 2 h / 0 °C
3.3: 1 h
View Scheme
3-chloro-2-methoxyaniline
51114-68-2

3-chloro-2-methoxyaniline

1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

Conditions
ConditionsYield
Stage #1: 3-chloro-2-methoxyaniline With hydrogenchloride In water at 50℃; for 0.5h;
Stage #2: With sodium nitrite In water at 0℃; for 2h;
Stage #3: With tetrafluoroboric acid In water for 1h; Temperature; Reagent/catalyst;
26 g
1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

Conditions
ConditionsYield
Stage #1: 1-chloro-3-fluoro-2-methoxybenzene With n-butyllithium In 1,2-dimethoxyethane at -78 - -70.1℃; for 1.75h;
Stage #2: With Trimethyl borate In 1,2-dimethoxyethane at -67 - 20℃; Time; Temperature; Further stages;
93%
Multi-step reaction with 2 steps
1.1: n-butyllithium / 1,2-dimethoxyethane; hexane / 1.75 h / -77 - -70.1 °C / Inert atmosphere
1.2: 1.37 h / -74.1 - 23.1 °C
2.1: potassium hydroxide; water / 1,2-dimethoxyethane / 2 h / 30 °C / Cooling
View Scheme
Trimethyl borate
121-43-7

Trimethyl borate

1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid
944129-07-1

(4-chloro-2-fluoro-3-methoxy-phenyl)boronic acid

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane; cyclohexane at -50℃; Flow reactor;92%
Stage #1: 1-chloro-3-fluoro-2-methoxybenzene With n-butyllithium In 1,2-dimethoxyethane at -65℃; Inert atmosphere;
Stage #2: Trimethyl borate In 1,2-dimethoxyethane at -65 - 30℃; Time; Inert atmosphere;
2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
61676-62-8

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

2-(4-chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
1126321-06-9

2-(4-chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane; cyclohexane at -50℃; Flow reactor;92%
N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

4-chloro-2-fluoro-3-methoxybenzaldehyde
1002344-97-9

4-chloro-2-fluoro-3-methoxybenzaldehyde

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane; cyclohexane at -50℃; Flow reactor;88%
1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

5-[(3R)-3-(3-chloro-2-methoxyphenoxy)pyrrolidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile

5-[(3R)-3-(3-chloro-2-methoxyphenoxy)pyrrolidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile

Conditions
ConditionsYield
Stage #1: 5-[(3R)-3-hydroxypyrrolidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile With sodium hydride In N,N-dimethyl-formamide at 0℃; for 1h;
Stage #2: 1-chloro-3-fluoro-2-methoxybenzene In N,N-dimethyl-formamide at 60℃; for 96h;
Stage #3: With water In ethyl acetate; N,N-dimethyl-formamide
74%
chloroacetyl chloride
79-04-9

chloroacetyl chloride

1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

C9H7Cl2FO2

C9H7Cl2FO2

Conditions
ConditionsYield
Stage #1: 1-chloro-3-fluoro-2-methoxybenzene With n-hexyllithium In tetrahydrofuran; hexane at -60℃; for 1h;
Stage #2: With zinc(II) chloride In tetrahydrofuran; hexane at -60 - -10℃;
Stage #3: chloroacetyl chloride; copper(l) chloride In tetrahydrofuran; hexane at -10 - 20℃; Further stages.;
71%
Benzyloxyacetyl chloride
19810-31-2

Benzyloxyacetyl chloride

1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

C16H14ClFO3

C16H14ClFO3

Conditions
ConditionsYield
Stage #1: 1-chloro-3-fluoro-2-methoxybenzene With n-hexyllithium In tetrahydrofuran; hexane at -60℃; for 1h;
Stage #2: With zinc(II) chloride In tetrahydrofuran; hexane at -60 - -10℃;
Stage #3: Benzyloxyacetyl chloride; copper(l) chloride In tetrahydrofuran; hexane at -10 - 20℃; Further stages.;
70%
carbon dioxide
124-38-9

carbon dioxide

1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

4-chloro-2-fluoro-3-methoxybenzoic acid
1169870-80-7

4-chloro-2-fluoro-3-methoxybenzoic acid

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane; cyclohexane at -50℃; Flow reactor;64%
1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

2-anilineboronic acid pinacol ester
191171-55-8

2-anilineboronic acid pinacol ester

C13H12FNO

C13H12FNO

Conditions
ConditionsYield
With allylchloro[1,3-bis(2,6-di-isopropylphenyl)imidazol-2-ylidene]palladium(II); barium(II) hydroxide In isopropyl alcohol at 80℃; for 6h;63%
methyl 4-methoxypicolinate
29681-43-4

methyl 4-methoxypicolinate

phenyl chloroformate
1885-14-9

phenyl chloroformate

1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

6-(4-chloro-2-fluoro-3-methoxyphenyl)-4-oxo-5,6-dihydro-4H-pyridine-1,2-dicarboxylic acid 2-methyl ester 1-phenyl ester
1257337-12-4

6-(4-chloro-2-fluoro-3-methoxyphenyl)-4-oxo-5,6-dihydro-4H-pyridine-1,2-dicarboxylic acid 2-methyl ester 1-phenyl ester

Conditions
ConditionsYield
Stage #1: 1-chloro-3-fluoro-2-methoxybenzene With n-butyllithium In tetrahydrofuran; hexane at -60 - -48℃; for 1h; Inert atmosphere;
Stage #2: With zinc(II) chloride In tetrahydrofuran; hexane at -45℃; for 2.5h;
Stage #3: methyl 4-methoxypicolinate; phenyl chloroformate
57%
1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

2-chloro-6-fluorophenol
2040-90-6

2-chloro-6-fluorophenol

Conditions
ConditionsYield
With pyridine hydrochloride
With boron tribromide In dichloromethane at -78 - 20℃; for 16h;
Hexanoyl chloride
142-61-0

Hexanoyl chloride

1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

A

1-(3-chloro-5-fluoro-4-methoxyphenyl)-1-hexanone
371757-70-9

1-(3-chloro-5-fluoro-4-methoxyphenyl)-1-hexanone

B

C12H14O2FCl

C12H14O2FCl

Conditions
ConditionsYield
With aluminium trichloride In dichloromethane Friedel-Crafts acylation;
1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

C14H16O2FCl

C14H16O2FCl

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: AlCl3 / CH2Cl2
2: K2CO3
View Scheme
1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

C14H16O2FCl

C14H16O2FCl

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: AlCl3 / CH2Cl2
2.2: H2SO4 / toluene
View Scheme
1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

α-bis-(2-Fluor-6-chlorphenoxy)essigsaeure
53145-35-0

α-bis-(2-Fluor-6-chlorphenoxy)essigsaeure

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Py*HCl
2: NaOEt
View Scheme
Hexanoyl chloride
142-61-0

Hexanoyl chloride

1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

1-(3-chloro-5-fluoro-4-methoxyphenyl)-1-hexanone
371757-70-9

1-(3-chloro-5-fluoro-4-methoxyphenyl)-1-hexanone

Conditions
ConditionsYield
aluminium trichloride In water
1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

6-chloro-2-fluoro-3-lithioanisole

6-chloro-2-fluoro-3-lithioanisole

Conditions
ConditionsYield
With n-butyllithium In 1,2-dimethoxyethane; hexane at -70 - -50℃; for 0.333333h; Product distribution / selectivity; Cooling with dry ice bath;
With n-butyllithium In tetrahydrofuran; hexane at -70 - -48℃; for 0.75h; Product distribution / selectivity;
With n-butyllithium In hexanes; 1,2-dimethoxyethane at -70 - -55℃; for 1.5h; Product distribution / selectivity;
With n-butyllithium In hexanes; 1,2-dimethoxyethane at -73.4 - -65℃; for 1.90333 - 4.48333h; Product distribution / selectivity; Cooling with acetone-dry ice;
With n-butyllithium In 1,2-dimethoxyethane; hexane at -72℃; for 2.01667h; Cooling with acetone-dry ice;
1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

zinc(II) chloride
7646-85-7

zinc(II) chloride

(4-chloro-2-fluoro-3-methoxyphenyl)zinc(II) chloride
1257337-33-9

(4-chloro-2-fluoro-3-methoxyphenyl)zinc(II) chloride

Conditions
ConditionsYield
Stage #1: 1-chloro-3-fluoro-2-methoxybenzene With n-butyllithium In tetrahydrofuran; hexane at -60 - -48℃; for 1h; Inert atmosphere;
Stage #2: zinc(II) chloride In tetrahydrofuran; hexane at -60 - -45℃; for 2.5h; Inert atmosphere;
Trimethyl borate
121-43-7

Trimethyl borate

1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

4-chloro-2-fluoro-3-methoxyphenyl dimethylboronate
1426539-30-1

4-chloro-2-fluoro-3-methoxyphenyl dimethylboronate

Conditions
ConditionsYield
With n-butyllithium In 1,2-dimethoxyethane; hexane for 0.616667h; Molecular sieve;
Stage #1: 1-chloro-3-fluoro-2-methoxybenzene With n-butyllithium In 1,2-dimethoxyethane; hexane at -77 - -70.1℃; for 1.75h; Inert atmosphere;
Stage #2: Trimethyl borate In 1,2-dimethoxyethane; hexane at -74.1 - 23.1℃; for 1.36667h;
1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

4,3'-dichloro-2-fluoro-3,2'-dimethoxybiphenyl
1426539-35-6

4,3'-dichloro-2-fluoro-3,2'-dimethoxybiphenyl

Conditions
ConditionsYield
Stage #1: 1-chloro-3-fluoro-2-methoxybenzene With n-butyllithium In 1,2-dimethoxyethane; hexane at -70℃; Molecular sieve; Inert atmosphere;
Stage #2: at -48 - 1℃; Inert atmosphere;
1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

halauxifen methyl ester

halauxifen methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium / 1,2-dimethoxyethane / -65 °C / Inert atmosphere
1.2: -65 - 30 °C / Inert atmosphere
2.1: palladium diacetate; triphenylphosphine / 1,2-dimethoxyethane; acetonitrile / Inert atmosphere
2.2: 2.5 h / 50 °C
3.1: acetyl chloride / methanol / 7 h / 50 °C / Inert atmosphere
View Scheme
1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate
943831-44-5

methyl 4-(acetylamino)-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: n-butyllithium / 1,2-dimethoxyethane / -65 °C / Inert atmosphere
1.2: -65 - 30 °C / Inert atmosphere
2.1: palladium diacetate; triphenylphosphine / 1,2-dimethoxyethane; acetonitrile / Inert atmosphere
2.2: 2.5 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1: n-butyllithium / 1,2-dimethoxyethane; hexane / 2.02 h / -72 °C / Cooling with acetone-dry ice
2: 1,2-dimethoxyethane; hexane / -72 °C / Cooling with acetone-dry ice
3: palladium diacetate; potassium carbonate; triphenylphosphine; tetrabutylammomium bromide / toluene; acetonitrile; water / 2 h / 65 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: n-butyllithium / 1,2-dimethoxyethane; hexane / 1.75 h / -77 - -70.1 °C / Inert atmosphere
1.2: 1.37 h / -74.1 - 23.1 °C
2.1: potassium hydroxide; water / 1,2-dimethoxyethane / 2 h / 30 °C / Cooling
3.1: ethyl acetate / 2 h / 23.1 °C / Inert atmosphere
4.1: triphenylphosphine; palladium diacetate / acetonitrile / 0.08 h / Inert atmosphere
4.2: 2 h / 60 °C / Inert atmosphere
View Scheme
1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

4-chloro-2-fluoro-3-methoxyphenyl dimethylboronate
1426539-30-1

4-chloro-2-fluoro-3-methoxyphenyl dimethylboronate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: n-butyllithium / 1,2-dimethoxyethane; hexane / 2.02 h / -72 °C / Cooling with acetone-dry ice
2: 1,2-dimethoxyethane; hexane / -72 °C / Cooling with acetone-dry ice
View Scheme
1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

2-(4-chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
1126321-06-9

2-(4-chloro-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium / 1,2-dimethoxyethane; hexane / 1.75 h / -77 - -70.1 °C / Inert atmosphere
1.2: 1.37 h / -74.1 - 23.1 °C
2.1: potassium hydroxide; water / 1,2-dimethoxyethane / 2 h / 30 °C / Cooling
3.1: ethyl acetate / 2 h / 23.1 °C / Inert atmosphere
View Scheme
N-fluorobis(benzenesulfon)imide
133745-75-2

N-fluorobis(benzenesulfon)imide

1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

A

N-(3-chloro-5-fluoro-4-methoxyphenyl)-N-(phenylsulfonyl)benzenesulfonamide
1453101-06-8

N-(3-chloro-5-fluoro-4-methoxyphenyl)-N-(phenylsulfonyl)benzenesulfonamide

B

C19H15ClFNO5S2
1453101-26-2

C19H15ClFNO5S2

Conditions
ConditionsYield
With [Ag(2,2'-bipyridine)2](ClO4); C20H28N4O2Pd*2CHF3O3S In acetonitrile at 23℃; for 24h; Inert atmosphere; Sealed tube; Overall yield = 78 %; Overall yield = 106.7 mg;
N-fluorobis(benzenesulfon)imide
133745-75-2

N-fluorobis(benzenesulfon)imide

1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

A

N-(3-chloro-5-fluoro-4-methoxyphenyl)-N-(phenylsulfonyl)benzenesulfonamide
1453101-06-8

N-(3-chloro-5-fluoro-4-methoxyphenyl)-N-(phenylsulfonyl)benzenesulfonamide

B

C19H15ClFNO5S2
1453101-26-2

C19H15ClFNO5S2

C

C19H15ClFNO5S2

C19H15ClFNO5S2

Conditions
ConditionsYield
With [Ag(2,2'-bipyridine)2](ClO4); C20H28N4O2Pd(2+)*2CF3O3S(1-) In acetonitrile at 23℃; for 24h; Inert atmosphere; Sealed tube; Overall yield = 78 %; Overall yield = 106.7 mg;
1-chloro-3-fluoro-2-methoxybenzene
53145-38-3

1-chloro-3-fluoro-2-methoxybenzene

C31H32FNO2

C31H32FNO2

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: allylchloro[1,3-bis(2,6-di-isopropylphenyl)imidazol-2-ylidene]palladium(II); barium(II) hydroxide / isopropyl alcohol / 6 h / 80 °C
2: Amberlyst 15(H) / toluene / 6 h / Dean-Stark; Reflux
View Scheme

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