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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Vasicine Manufacturer/High quality/Best price/In stock

Cas:6159-55-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Natural Extract 98% VASICINE 6159-55-3 HACCP Manufacturer

Cas:6159-55-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Vasicine

Cas:6159-55-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 6159-55-3 with best quality

Cas:6159-55-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Pyrrolo[2,1-b]quinazolin-3-ol,1,2,3,9-tetrahydro-, (3S)- 6159-55-3

Cas:6159-55-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

What's Vasicine Vasicine, isolated from A. Vasica, is an alkaloid. It is a natural cholinesterase (cholinesterase) inhibitor with anticholinesterase activity in preclinical models and can be used for therapeutic drug development in Alzheimer&

Herbal Extract CAS: 6159-55-3 Adhatoda Vasica Extract Powder 1% 2.5% Vasicine.

Cas:6159-55-3

Min.Order:1 Gram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

VASICINE CAS:6159-55-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

VASICINE CAS:6159-55-3

Cas:6159-55-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Pyrrolo[2,1-b]quinazolin-3-ol,1,2,3,9-tetrahydro-, (3S)-

Cas:6159-55-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Pyrrolo[2,1-b]quinazolin-3-ol,1,2,3,9-tetrahydro-, (3S)-

Cas:6159-55-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

vasicine

Cas:6159-55-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply vasicine

Cas:6159-55-3

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Pyrrolo[2,1-b]quinazolin-3-ol,1,2,3,9-tetrahydro-, (3S)-

Cas:6159-55-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

VASICINE

Cas:6159-55-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Vasicine

Cas:6159-55-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Peganine

Cas:6159-55-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment . Application:Herbal extr

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec Vasicine V61840 5mg

Cas:6159-55-3

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Vasicine (20 mg)

Cas:6159-55-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Product Name: VASICINE Synonyms: 1-b)quinazolin-3-ol,1,2,3,9-tetrahydro-pyrrolo(;vasicin;1,2,3,9-TETRAHYDROPYRROLO[2,1-B]QUINAZOLIN-3-OL;AKOS NCG1-0080;VITAS-BB TBB000541;VASICINE;PEGANINE;C10733 CAS: 6159-55-3 MF: C11H12N2O MW: 188.23 EINEC

TAINFUCHEM: VASICINE

Cas:6159-55-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Pyrrolo[2,1-b]quinazolin-3-ol,1,2,3,9-tetrahydro-, (3S)-

Cas:6159-55-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

VASICINE CAS No.6159-55-3

Cas:6159-55-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:Powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as primary and sec

Vasicine

Cas:6159-55-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

Vasicine cas 6159-55-3Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Vasicine cas 6159-55-3

Cas:6159-55-3

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

VASICINE

Cas:6159-55-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:5mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any port

Vasicine

Cas:6159-55-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

VASICINE

Cas:6159-55-3

Min.Order:0

Negotiable

Type:Other

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

6159-55-3

Cas:6159-55-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

shanghai Tauto Biotech Co., Ltd

Appearance:powder or crystal Storage:-20degree Package:10mg,20mg,1g or on request Application:For research use only, like HPLC, Cell Culture, Animal Experiment, High Throughout Screening, etc.. Transportation:room temperature

Vasicine

Cas:6159-55-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

VASICINE

Cas:6159-55-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

VASICINE

Cas:6159-55-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

(+)-vasicinol
6159-55-3

(+)-vasicinol

Conditions
ConditionsYield
With D-tartaric acid

A

vasicine
18549-38-7

vasicine

B

(+)-vasicinol
6159-55-3

(+)-vasicinol

Conditions
ConditionsYield
With 2,2'-iminobis[ethanol] In ethanol Resolution of racemate;
(+)-vasicinol
6159-55-3

(+)-vasicinol

(3S)-1-[(2-aminophenyll)methyl]pyrrolidin-3-ol
1227263-77-5

(3S)-1-[(2-aminophenyll)methyl]pyrrolidin-3-ol

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol; water for 2h; Solvent;99%
With sodium tetrahydroborate In methanol; water at 20℃; for 2h;99%
With sodium tetrahydroborate; water In methanol at 20℃;90%
(+)-vasicinol
6159-55-3

(+)-vasicinol

(3S)-1,2,3,3a,4,9-hexahydropyrrolo[2,1-b]quinazolin-3-ol

(3S)-1,2,3,3a,4,9-hexahydropyrrolo[2,1-b]quinazolin-3-ol

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol at 20℃; for 1h; Solvent;95%
(+)-vasicinol
6159-55-3

(+)-vasicinol

A

(3S)-1-[(2-aminophenyll)methyl]pyrrolidin-3-ol
1227263-77-5

(3S)-1-[(2-aminophenyll)methyl]pyrrolidin-3-ol

B

(3S)-1,2,3,3a,4,9-hexahydropyrrolo[2,1-b]quinazolin-3-ol

(3S)-1,2,3,3a,4,9-hexahydropyrrolo[2,1-b]quinazolin-3-ol

Conditions
ConditionsYield
With sodium tetrahydroborate In methanol; water for 2h; Solvent;A 80%
B 10%
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride
39637-99-5, 20445-33-4

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

(+)-vasicinol
6159-55-3

(+)-vasicinol

vasicine (R)-α-methoxy-α-(trifluoromethyl)phenylacetic acid ester

vasicine (R)-α-methoxy-α-(trifluoromethyl)phenylacetic acid ester

(R)-methoxytrifluoromethylphenylacetyl chloride
20445-33-4, 39637-99-5

(R)-methoxytrifluoromethylphenylacetyl chloride

(+)-vasicinol
6159-55-3

(+)-vasicinol

vasicine (S)-α-methoxy-α-(trifluoromethyl)phenylacetic acid ester

vasicine (S)-α-methoxy-α-(trifluoromethyl)phenylacetic acid ester

(+)-vasicinol
6159-55-3

(+)-vasicinol

(R)-N-benzyl-3-hydroxypyrrolidine
101385-90-4, 101930-07-8, 101979-03-7, 775-15-5

(R)-N-benzyl-3-hydroxypyrrolidine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: water; sodium tetrahydroborate / methanol / 10 h / 20 °C
2.1: hypophosphorous acid; sodium azide; sulfuric acid; acetic acid / water / 39.5 h / 5 °C
2.2: pH 8
3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere
3.2: 16 h / 20 °C / Inert atmosphere
4.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 2 h / 0 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate / methanol; water / 2 h
2.1: isopentyl nitrite / N,N-dimethyl-formamide / 0.5 h / 65 °C
3.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere
3.2: 16 h / 20 °C / Inert atmosphere
4.1: lithium hydroxide monohydrate / methanol; tetrahydrofuran / 2 h / 0 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium tetrahydroborate / methanol; water / 2 h
2.1: isopentyl nitrite / N,N-dimethyl-formamide / 0.5 h / 65 °C
3.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere
3.2: 16 h / 20 °C / Inert atmosphere
4.1: lithium hydroxide monohydrate / methanol; tetrahydrofuran / 2 h / 0 °C
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(S)-N-benzyl-3-hydroxypyrrolidine
101385-90-4

(S)-N-benzyl-3-hydroxypyrrolidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: water; sodium tetrahydroborate / methanol / 10 h / 20 °C
2.1: hypophosphorous acid; sodium azide; sulfuric acid; acetic acid / water / 39.5 h / 5 °C
2.2: pH 8
View Scheme
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / methanol; water / 2 h
2: isopentyl nitrite / N,N-dimethyl-formamide / 0.5 h / 65 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / methanol; water / 2 h
2: isopentyl nitrite / N,N-dimethyl-formamide / 0.5 h / 65 °C
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(3R)-1-(phenylmethyl)pyrrolidin-3-ol Acetate
116143-02-3

(3R)-1-(phenylmethyl)pyrrolidin-3-ol Acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: water; sodium tetrahydroborate / methanol / 10 h / 20 °C
2.1: hypophosphorous acid; sodium azide; sulfuric acid; acetic acid / water / 39.5 h / 5 °C
2.2: pH 8
3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere
3.2: 16 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: sodium tetrahydroborate / methanol; water / 2 h
2.1: isopentyl nitrite / N,N-dimethyl-formamide / 0.5 h / 65 °C
3.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere
3.2: 16 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: sodium tetrahydroborate / methanol; water / 2 h
2.1: isopentyl nitrite / N,N-dimethyl-formamide / 0.5 h / 65 °C
3.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere
3.2: 16 h / 20 °C / Inert atmosphere
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

3-chloro-3-deoxyvasicine

3-chloro-3-deoxyvasicine

Conditions
ConditionsYield
With POCl3#PCl5
(+)-vasicinol
6159-55-3

(+)-vasicinol

deoxypeganine
495-59-0

deoxypeganine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: POCl3#PCl5
2:
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(S)-3-hydroxy-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
486-64-6

(S)-3-hydroxy-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one

Conditions
ConditionsYield
With dihydrogen peroxide In acetone
(+)-vasicinol
6159-55-3

(+)-vasicinol

2-[(3-chloropyrrolidin-1-yl)methyl]benzenamine

2-[(3-chloropyrrolidin-1-yl)methyl]benzenamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: POCl3#PCl5
2: sodium tetrahydroborate / methanol; water / 2 h
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

2-(pyrrolidin-1-ylmethyl)benzenamine
55727-59-8

2-(pyrrolidin-1-ylmethyl)benzenamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: POCl3#PCl5
2:
3: sodium tetrahydroborate / methanol; water / 2 h
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(R)-(3-(4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)pyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

(R)-(3-(4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)pyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium tetrahydroborate; methanol / water
2.1: potassium carbonate / toluene / 6 h / Reflux
3.1: 1H-imidazole / dichloromethane / 20 h / 20 °C
4.1: benzyl(triethyl)ammoniumpermanganate / dichloromethane / 4 h / Reflux
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C
6.1: tetrahydrofuran / 5 h / 25 °C
7.1: triethylamine; dmap; p-toluenesulfonyl chloride / dichloromethane / 12.5 h / 0 - 15 °C
7.2: 4 h / 60 °C
7.3: 1 h / Acidic conditions
8.1: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 6 h / 50 - 60 °C
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(R)-(3-(4-phenyl-1H-1,2,3-triazol-1-yl)pyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

(R)-(3-(4-phenyl-1H-1,2,3-triazol-1-yl)pyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium tetrahydroborate; methanol / water
2.1: potassium carbonate / toluene / 6 h / Reflux
3.1: 1H-imidazole / dichloromethane / 20 h / 20 °C
4.1: benzyl(triethyl)ammoniumpermanganate / dichloromethane / 4 h / Reflux
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C
6.1: tetrahydrofuran / 5 h / 25 °C
7.1: triethylamine; dmap; p-toluenesulfonyl chloride / dichloromethane / 12.5 h / 0 - 15 °C
7.2: 4 h / 60 °C
7.3: 1 h / Acidic conditions
8.1: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 6 h / 50 - 60 °C
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(R)-(3-(4-hexyl-1H-1,2,3-triazol-1-yl)pyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

(R)-(3-(4-hexyl-1H-1,2,3-triazol-1-yl)pyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium tetrahydroborate; methanol / water
2.1: potassium carbonate / toluene / 6 h / Reflux
3.1: 1H-imidazole / dichloromethane / 20 h / 20 °C
4.1: benzyl(triethyl)ammoniumpermanganate / dichloromethane / 4 h / Reflux
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C
6.1: tetrahydrofuran / 5 h / 25 °C
7.1: triethylamine; dmap; p-toluenesulfonyl chloride / dichloromethane / 12.5 h / 0 - 15 °C
7.2: 4 h / 60 °C
7.3: 1 h / Acidic conditions
8.1: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 6 h / 50 - 60 °C
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(R)-(3-(4-(4-pentylphenyl)-1H-1,2,3-triazol-1-yl)pyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

(R)-(3-(4-(4-pentylphenyl)-1H-1,2,3-triazol-1-yl)pyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium tetrahydroborate; methanol / water
2.1: potassium carbonate / toluene / 6 h / Reflux
3.1: 1H-imidazole / dichloromethane / 20 h / 20 °C
4.1: benzyl(triethyl)ammoniumpermanganate / dichloromethane / 4 h / Reflux
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C
6.1: tetrahydrofuran / 5 h / 25 °C
7.1: triethylamine; dmap; p-toluenesulfonyl chloride / dichloromethane / 12.5 h / 0 - 15 °C
7.2: 4 h / 60 °C
7.3: 1 h / Acidic conditions
8.1: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 6 h / 50 - 60 °C
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(R)-(3-(4-pentyl-1H-1,2,3-triazol-1-yl)pyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

(R)-(3-(4-pentyl-1H-1,2,3-triazol-1-yl)pyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium tetrahydroborate; methanol / water
2.1: potassium carbonate / toluene / 6 h / Reflux
3.1: 1H-imidazole / dichloromethane / 20 h / 20 °C
4.1: benzyl(triethyl)ammoniumpermanganate / dichloromethane / 4 h / Reflux
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C
6.1: tetrahydrofuran / 5 h / 25 °C
7.1: triethylamine; dmap; p-toluenesulfonyl chloride / dichloromethane / 12.5 h / 0 - 15 °C
7.2: 4 h / 60 °C
7.3: 1 h / Acidic conditions
8.1: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 6 h / 50 - 60 °C
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(R)-(3-(4-propyl-1H-1,2,3-triazol-1-yl)pyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

(R)-(3-(4-propyl-1H-1,2,3-triazol-1-yl)pyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium tetrahydroborate; methanol / water
2.1: potassium carbonate / toluene / 6 h / Reflux
3.1: 1H-imidazole / dichloromethane / 20 h / 20 °C
4.1: benzyl(triethyl)ammoniumpermanganate / dichloromethane / 4 h / Reflux
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C
6.1: tetrahydrofuran / 5 h / 25 °C
7.1: triethylamine; dmap; p-toluenesulfonyl chloride / dichloromethane / 12.5 h / 0 - 15 °C
7.2: 4 h / 60 °C
7.3: 1 h / Acidic conditions
8.1: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 6 h / 50 - 60 °C
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(S)-1-(2-(pyridin-4-ylamino)benzyl)pyrrolidin-3-ol

(S)-1-(2-(pyridin-4-ylamino)benzyl)pyrrolidin-3-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium tetrahydroborate; methanol / water
2: potassium carbonate / toluene / 6 h / Reflux
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(2-((3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)methyl)phenyl)pyridin-4-amine

(2-((3-((tert-butyldimethylsilyl)oxy)pyrrolidin-1-yl)methyl)phenyl)pyridin-4-amine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium tetrahydroborate; methanol / water
2: potassium carbonate / toluene / 6 h / Reflux
3: 1H-imidazole / dichloromethane / 20 h / 20 °C
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(S)-(3-((tertbutyldimethylsilyl)oxy)pyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

(S)-(3-((tertbutyldimethylsilyl)oxy)pyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium tetrahydroborate; methanol / water
2: potassium carbonate / toluene / 6 h / Reflux
3: 1H-imidazole / dichloromethane / 20 h / 20 °C
4: benzyl(triethyl)ammoniumpermanganate / dichloromethane / 4 h / Reflux
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(S)-(3-hydroxypyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

(S)-(3-hydroxypyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium tetrahydroborate; methanol / water
2: potassium carbonate / toluene / 6 h / Reflux
3: 1H-imidazole / dichloromethane / 20 h / 20 °C
4: benzyl(triethyl)ammoniumpermanganate / dichloromethane / 4 h / Reflux
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(S)-tert-butyl(2-(3-hydroxypyrrolidine-1-carbonyl)phenyl)(pyridin-4-yl)carbamate

(S)-tert-butyl(2-(3-hydroxypyrrolidine-1-carbonyl)phenyl)(pyridin-4-yl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: sodium tetrahydroborate; methanol / water
2: potassium carbonate / toluene / 6 h / Reflux
3: 1H-imidazole / dichloromethane / 20 h / 20 °C
4: benzyl(triethyl)ammoniumpermanganate / dichloromethane / 4 h / Reflux
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C
6: tetrahydrofuran / 5 h / 25 °C
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(R)-(3-azidopyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

(R)-(3-azidopyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium tetrahydroborate; methanol / water
2.1: potassium carbonate / toluene / 6 h / Reflux
3.1: 1H-imidazole / dichloromethane / 20 h / 20 °C
4.1: benzyl(triethyl)ammoniumpermanganate / dichloromethane / 4 h / Reflux
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C
6.1: tetrahydrofuran / 5 h / 25 °C
7.1: triethylamine; dmap; p-toluenesulfonyl chloride / dichloromethane / 12.5 h / 0 - 15 °C
7.2: 4 h / 60 °C
7.3: 1 h / Acidic conditions
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(R)-(3-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)pyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

(R)-(3-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)pyrrolidin-1-yl)(2-(pyridin-4-ylamino)phenyl)methanone

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium tetrahydroborate; methanol / water
2.1: potassium carbonate / toluene / 6 h / Reflux
3.1: 1H-imidazole / dichloromethane / 20 h / 20 °C
4.1: benzyl(triethyl)ammoniumpermanganate / dichloromethane / 4 h / Reflux
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C
6.1: tetrahydrofuran / 5 h / 25 °C
7.1: triethylamine; dmap; p-toluenesulfonyl chloride / dichloromethane / 12.5 h / 0 - 15 °C
7.2: 4 h / 60 °C
7.3: 1 h / Acidic conditions
8.1: copper(II) sulfate; sodium L-ascorbate / water; tert-butyl alcohol / 6 h / 50 - 60 °C
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(S)-methyl-9-((2-((3-hydroxypyrrolidin-1-yl)methyl)phenyl)-amino)-9-oxononanoate

(S)-methyl-9-((2-((3-hydroxypyrrolidin-1-yl)methyl)phenyl)-amino)-9-oxononanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / methanol; water / 2 h / 20 °C
2: boric acid / toluene / 3 h / Molecular sieve; Inert atmosphere; Reflux
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(S)-methyl-5-((2-((3-hydroxypyrrolidin-1-yl)methyl)phenyl)-amino)-5-oxopentanoate

(S)-methyl-5-((2-((3-hydroxypyrrolidin-1-yl)methyl)phenyl)-amino)-5-oxopentanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / methanol; water / 2 h / 20 °C
2: boric acid / toluene / 3 h / Molecular sieve; Inert atmosphere; Reflux
View Scheme
(+)-vasicinol
6159-55-3

(+)-vasicinol

(S)-methyl 6-((2-((3-hydroxypyrrolidin-1-yl)methyl)phenyl)-amino)-6-oxohexanoate

(S)-methyl 6-((2-((3-hydroxypyrrolidin-1-yl)methyl)phenyl)-amino)-6-oxohexanoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / methanol; water / 2 h / 20 °C
2: boric acid / toluene / 3 h / Molecular sieve; Inert atmosphere; Reflux
View Scheme

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