Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:61869-08-7
Min.Order:1 Kilogram
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inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:61869-08-7
Min.Order:1 Gram
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Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:61869-08-7
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:61869-08-7
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:61869-08-7
Min.Order:1 Kilogram
FOB Price: $7.0 / 9.0
Type:Trading Company
inquirySynonyms: Paroxetine Molecular Formula: C19H20FNO3 Molecular Weight: 329.37 CAS No.:
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:61869-08-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryParoxetine CAS:61869-08-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:61869-08-7
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryWe have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful
Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:61869-08-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:61869-08-7
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Type:Lab/Research institutions
inquiryQ1: Are you a manufacturer?Answer: Yes, we are factory founded on 2002. Q2: How to contact with us?Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours. Q3:Which kind of payment terms do yo
Cas:61869-08-7
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Type:Trading Company
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater
Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Paroxetine cas 61869-08-7 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control syste
Cas:61869-08-7
Min.Order:1 Kilogram
FOB Price: $10.0 / 50.0
Type:Trading Company
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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Cas:61869-08-7
Min.Order:100 Gram
FOB Price: $10.0 / 100.0
Type:Trading Company
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:61869-08-7
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiryEstablished in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site
Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:61869-08-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
paroxetine
Conditions | Yield |
---|---|
With acetic acid; zinc at 20℃; for 6h; | 98% |
With acetic acid; zinc at 20℃; for 6h; | 96% |
(3S,4R)-1-benzyl-4-(4-fluorophenyl)-3-[3,4-(methylenedioxy)-phenoxymethyl]piperidine
paroxetine
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen; acetic acid; isopropyl alcohol at 50℃; under 4500.45 Torr; for 15h; stereoselective reaction; | 97% |
With hydrogen; palladium on activated charcoal In acetic acid; isopropyl alcohol at 50℃; under 4500.36 Torr; for 15h; | 96% |
With palladium on activated charcoal; hydrogen; acetic acid In isopropyl alcohol | 92% |
Stage #1: (3S,4R)-1-benzyl-4-(4-fluorophenyl)-3-[3,4-(methylenedioxy)-phenoxymethyl]piperidine With 1-chloroethyl chloroformate In 1,2-dichloro-ethane for 3h; Heating; Stage #2: In methanol for 2h; Heating; | 54% |
(3S,4R)-4-(4-fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)-1-vinyloxycarbonylpiperidine
paroxetine
Conditions | Yield |
---|---|
Stage #1: (3S,4R)-4-(4-fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)-1-vinyloxycarbonylpiperidine With hydrogenchloride In 1,2-dichloro-ethane for 0.75h; Stage #2: In ethanol for 1.5h; Heating; | 96% |
(S)-5-(benzo[1,3]dioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidin-2-one
paroxetine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In diethyl ether at 0 - 20℃; | 90% |
(3S,4R)-1-(tert-butoxycarbonyl)-4-(p-fluorophenyl)-3-[3,4-(methylenedioxy)phenoxymethyl]piperidine
paroxetine
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 20℃; for 0.333333h; | 75% |
With trifluoroacetic acid In dichloromethane at 20℃; for 0.25h; Boc-deprotection; | 72% |
With trifluoroacetic acid In dichloromethane for 0.25h; | 99 mg |
(3R,4S)-5-amino-4-((benzo[d][1,3]dioxol-5-yloxy)methyl)-3-(4-fluorophenyl)pentan-1-ol
paroxetine
Conditions | Yield |
---|---|
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 20℃; for 2.5h; Inert atmosphere; | 71% |
paroxetine
Conditions | Yield |
---|---|
With pyrrolidine; samarium diiodide In tetrahydrofuran; water at 20℃; for 0.0833333h; | 61% |
(3S,4R)-3-(Benzo[1,3]dioxol-5-yloxymethyl)-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid methyl ester
paroxetine
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol; water at 110℃; for 42h; | 61% |
(3S,4R)-1-(tert-butoxycarbonyl)-4-(p-fluorophenyl)-3-[3,4-(methylenedioxy)phenoxymethyl]piperidine
B
paroxetine
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane for 1.5h; Title compound not separated from byproducts.; |
(3S,4R)-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid methyl ester
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: LiAlH4 / tetrahydrofuran / 20 h / Heating 2.1: 100 percent / Et3N / CH2Cl2 / 0 - 20 °C 3.1: NaH / dimethylformamide / 0.33 h / 20 °C 3.2: 52 percent / dimethylformamide / 14 h / 90 °C 4.1: 96 percent / hydrogen / Pd/C / acetic acid; propan-2-ol / 15 h / 50 °C / 4500.36 Torr View Scheme |
Sesamol
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: NaH / dimethylformamide / 0.33 h / 20 °C 1.2: 52 percent / dimethylformamide / 14 h / 90 °C 2.1: 96 percent / hydrogen / Pd/C / acetic acid; propan-2-ol / 15 h / 50 °C / 4500.36 Torr View Scheme | |
Multi-step reaction with 3 steps 1.1: 80 percent / NaH / dimethylformamide / 4 h / Heating 2.1: 75 percent / potassium carbonate / 1,2-dichloro-ethane / 4 h / Heating 3.1: hydrogen chloride / 1,2-dichloro-ethane / 0.75 h 3.2: 96 percent / ethanol / 1.5 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: 76 mg / NaOMe / methanol / 1.5 h / Heating 2: 72 percent / TFA / CH2Cl2 / 0.25 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 10 h / 85 °C / Inert atmosphere 2.1: 9-borabicyclo[3.3.1]nonane dimer / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere 2.2: 1 h / 20 °C / Inert atmosphere 3.1: hydrazine hydrate / ethanol / 0.58 h / 20 - 85 °C / Inert atmosphere 4.1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 2.5 h / 20 °C / Inert atmosphere View Scheme |
(3S,4R)-[1-benzyl-4-piperidin-3-yl-4-(4-fluorophenyl)]methanol
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 100 percent / Et3N / CH2Cl2 / 0 - 20 °C 2.1: NaH / dimethylformamide / 0.33 h / 20 °C 2.2: 52 percent / dimethylformamide / 14 h / 90 °C 3.1: 96 percent / hydrogen / Pd/C / acetic acid; propan-2-ol / 15 h / 50 °C / 4500.36 Torr View Scheme | |
Multi-step reaction with 3 steps 1.1: pyridine / 1 h / 10 °C 2.1: 81 mg / NaOMe / methanol / Heating 3.1: 1-chloroethyl formate / 1,2-dichloro-ethane / 3 h / Heating 3.2: 54 percent / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / toluene 2: sodium hydride / N,N-dimethyl-formamide 3: palladium on activated charcoal; hydrogen; acetic acid / isopropyl alcohol View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / 0.33 h / 0 - 20 °C / Inert atmosphere 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C / Inert atmosphere 2.2: 15 h / 90 °C / Inert atmosphere 3.1: acetic acid; palladium 10% on activated carbon; isopropyl alcohol; hydrogen / 15 h / 50 °C / 4500.45 Torr View Scheme |
Methanesulfonic acid (3S,4R)-1-benzyl-4-(4-fluoro-phenyl)-piperidin-3-ylmethyl ester
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: NaH / dimethylformamide / 0.33 h / 20 °C 1.2: 52 percent / dimethylformamide / 14 h / 90 °C 2.1: 96 percent / hydrogen / Pd/C / acetic acid; propan-2-ol / 15 h / 50 °C / 4500.36 Torr View Scheme | |
Multi-step reaction with 2 steps 1.1: 81 mg / NaOMe / methanol / Heating 2.1: 1-chloroethyl formate / 1,2-dichloro-ethane / 3 h / Heating 2.2: 54 percent / methanol / 2 h / Heating View Scheme |
1-(phenylmethyl)-4-(4-fluorophenyl)piperidin-2,6-dione
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: chiral bis-lithium amide base / tetrahydrofuran; hexane / 0.75 h / -78 °C 1.2: 71 percent / tetrahydrofuran; hexane / -40 °C 2.1: LiAlH4 / tetrahydrofuran / Heating 3.1: pyridine / 1 h / 10 °C 4.1: 81 mg / NaOMe / methanol / Heating 5.1: 1-chloroethyl formate / 1,2-dichloro-ethane / 3 h / Heating 5.2: 54 percent / methanol / 2 h / Heating View Scheme |
(3S,4R)-1-benzyl-4-(4-fluorophenyl)-2,6-dioxopiperidine-3-carboxylic acid methyl ester
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: LiAlH4 / tetrahydrofuran / Heating 2.1: pyridine / 1 h / 10 °C 3.1: 81 mg / NaOMe / methanol / Heating 4.1: 1-chloroethyl formate / 1,2-dichloro-ethane / 3 h / Heating 4.2: 54 percent / methanol / 2 h / Heating View Scheme |
3-chloro-4'-fluoropropiophenone
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: 77 percent / Et3N / tetrahydrofuran / 4 h / Heating 2: Na2CO3 / CH2Cl2 / 0.5 h 3: 8.36 g / EtONa / ethanol / 0.5 h / Heating 4: 89 percent / CuCl2; t-BuONa; (R)-p-tolBINAP / PMHS; tert-amyl alcohol / fluorobenzene / 0.75 h 5: 79 percent / MeOH; NaH / toluene / 4 h / Heating 6: 98 percent / BH3 / tetrahydrofuran / 18 h / Heating 7: CAN / acetonitrile; H2O / 0.5 h / 20 °C 8: 268 mg / NaOH / toluene; H2O / 3 h / 20 °C 9: Cs2CO3 / o-xylene / 20 h / 130 °C 10: 99 mg / TFA / CH2Cl2 / 0.25 h View Scheme |
1-(4-fluorophenyl)-3-(4-methoxyphenylamino)propan-1-one
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: Na2CO3 / CH2Cl2 / 0.5 h 2: 8.36 g / EtONa / ethanol / 0.5 h / Heating 3: 89 percent / CuCl2; t-BuONa; (R)-p-tolBINAP / PMHS; tert-amyl alcohol / fluorobenzene / 0.75 h 4: 79 percent / MeOH; NaH / toluene / 4 h / Heating 5: 98 percent / BH3 / tetrahydrofuran / 18 h / Heating 6: CAN / acetonitrile; H2O / 0.5 h / 20 °C 7: 268 mg / NaOH / toluene; H2O / 3 h / 20 °C 8: Cs2CO3 / o-xylene / 20 h / 130 °C 9: 99 mg / TFA / CH2Cl2 / 0.25 h View Scheme |
(3S,4R)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Cs2CO3 / o-xylene / 20 h / 130 °C 2: 99 mg / TFA / CH2Cl2 / 0.25 h View Scheme | |
Multi-step reaction with 3 steps 1: Et3N / CH2Cl2 / 0.17 h / 20 °C 2: 0.127 g / NaH / dimethylformamide / 0.25 h / Heating 3: TFA / CH2Cl2 / 1.5 h View Scheme | |
Multi-step reaction with 3 steps 1: 100 mg / pyridine / 1 h / 10 °C 2: 76 mg / NaOMe / methanol / 1.5 h / Heating 3: 72 percent / TFA / CH2Cl2 / 0.25 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 1.5 h / 20 °C 2: sodium hydride / tetrahydrofuran; mineral oil / 6 h / 20 °C / Reflux 3: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C View Scheme |
(3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethylpiperidine
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 268 mg / NaOH / toluene; H2O / 3 h / 20 °C 2: Cs2CO3 / o-xylene / 20 h / 130 °C 3: 99 mg / TFA / CH2Cl2 / 0.25 h View Scheme |
4-(4-fluorophenyl)-1-(4-methoxyphenyl)-5,6-dihydro-1H-pyridin-2-one
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 89 percent / CuCl2; t-BuONa; (R)-p-tolBINAP / PMHS; tert-amyl alcohol / fluorobenzene / 0.75 h 2: 79 percent / MeOH; NaH / toluene / 4 h / Heating 3: 98 percent / BH3 / tetrahydrofuran / 18 h / Heating 4: CAN / acetonitrile; H2O / 0.5 h / 20 °C 5: 268 mg / NaOH / toluene; H2O / 3 h / 20 °C 6: Cs2CO3 / o-xylene / 20 h / 130 °C 7: 99 mg / TFA / CH2Cl2 / 0.25 h View Scheme |
(4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-piperidin-2-one
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 79 percent / MeOH; NaH / toluene / 4 h / Heating 2: 98 percent / BH3 / tetrahydrofuran / 18 h / Heating 3: CAN / acetonitrile; H2O / 0.5 h / 20 °C 4: 268 mg / NaOH / toluene; H2O / 3 h / 20 °C 5: Cs2CO3 / o-xylene / 20 h / 130 °C 6: 99 mg / TFA / CH2Cl2 / 0.25 h View Scheme |
[(3S,4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-piperidin-3-yl]methanol
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: CAN / acetonitrile; H2O / 0.5 h / 20 °C 2: 268 mg / NaOH / toluene; H2O / 3 h / 20 °C 3: Cs2CO3 / o-xylene / 20 h / 130 °C 4: 99 mg / TFA / CH2Cl2 / 0.25 h View Scheme |
(3S,4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-2-oxopiperidin-3-carboxylic acid methyl ester
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 98 percent / BH3 / tetrahydrofuran / 18 h / Heating 2: CAN / acetonitrile; H2O / 0.5 h / 20 °C 3: 268 mg / NaOH / toluene; H2O / 3 h / 20 °C 4: Cs2CO3 / o-xylene / 20 h / 130 °C 5: 99 mg / TFA / CH2Cl2 / 0.25 h View Scheme |
N-[3-(4-fluoro-phenyl)-3-oxo-propyl]-N-(4-methoxy-phenyl)-malonamic acid ethyl ester
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 8.36 g / EtONa / ethanol / 0.5 h / Heating 2: 89 percent / CuCl2; t-BuONa; (R)-p-tolBINAP / PMHS; tert-amyl alcohol / fluorobenzene / 0.75 h 3: 79 percent / MeOH; NaH / toluene / 4 h / Heating 4: 98 percent / BH3 / tetrahydrofuran / 18 h / Heating 5: CAN / acetonitrile; H2O / 0.5 h / 20 °C 6: 268 mg / NaOH / toluene; H2O / 3 h / 20 °C 7: Cs2CO3 / o-xylene / 20 h / 130 °C 8: 99 mg / TFA / CH2Cl2 / 0.25 h View Scheme |
(3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 89 percent / trimethylamine hydrochloride / CH2Cl2 / 4 h / cooling 2.1: 80 percent / NaH / dimethylformamide / 4 h / Heating 3.1: 75 percent / potassium carbonate / 1,2-dichloro-ethane / 4 h / Heating 4.1: hydrogen chloride / 1,2-dichloro-ethane / 0.75 h 4.2: 96 percent / ethanol / 1.5 h / Heating View Scheme |
(3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidine
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 75 percent / potassium carbonate / 1,2-dichloro-ethane / 4 h / Heating 2.1: hydrogen chloride / 1,2-dichloro-ethane / 0.75 h 2.2: 96 percent / ethanol / 1.5 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1.1: toluene / 3.75 h / 100 - 105 °C / Large scale reaction 1.2: 1 h / 60 °C 1.3: 25 - 35 °C 2.1: water; sodium hydroxide / isopropyl alcohol / 82 - 85 °C / Large scale reaction View Scheme |
(3S,4R)-trans-4-(4-fluorophenyl)-1-methyl-3-p-toluenesulphonyloxymethyl-piperidine
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: 80 percent / NaH / dimethylformamide / 4 h / Heating 2.1: 75 percent / potassium carbonate / 1,2-dichloro-ethane / 4 h / Heating 3.1: hydrogen chloride / 1,2-dichloro-ethane / 0.75 h 3.2: 96 percent / ethanol / 1.5 h / Heating View Scheme |
(3S,4R)-tert-butyl 4-(4-fluorophenyl)-3-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 0.127 g / NaH / dimethylformamide / 0.25 h / Heating 2: TFA / CH2Cl2 / 1.5 h View Scheme | |
Multi-step reaction with 2 steps 1: 76 mg / NaOMe / methanol / 1.5 h / Heating 2: 72 percent / TFA / CH2Cl2 / 0.25 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydride / tetrahydrofuran; mineral oil / 6 h / 20 °C / Reflux 2: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C View Scheme |
paroxetine
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 0.761 g / NaBH4 / methanol / 1 h 2: ammonium formate / Pd/C / methanol / 0.5 h / Heating 3: 0.702 g / CH2Cl2 / 2 h / 20 °C 4: Et3N / tetrahydrofuran / 0.17 h / 20 °C 5: KOt-Bu / tetrahydrofuran / 0.5 h / 0 °C 6: 0.327 g / TBAF / tetrahydrofuran / 12 h 7: Et3N / CH2Cl2 / 0.17 h / 20 °C 8: 0.127 g / NaH / dimethylformamide / 0.25 h / Heating 9: TFA / CH2Cl2 / 1.5 h View Scheme |
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 20℃; for 16h; | 98% |
trifluoroacetic acid
paroxetine
Conditions | Yield |
---|---|
With potassium phosphate; 18-crown-6 ether; phenylsilane In tetrahydrofuran at 80℃; for 8h; Glovebox; Molecular sieve; Schlenk technique; | 96% |
4-chlorobenzenesulfonyl chloride
paroxetine
Conditions | Yield |
---|---|
With sodium carbonate In water at 20℃; for 3h; pH=9 - 10; Green chemistry; | 90% |
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 20℃; | 88% |
formaldehyd
paroxetine
(3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidine
Conditions | Yield |
---|---|
With formic acid; triethylamine In water; tert-butyl alcohol at 100℃; for 14h; | 87% |
Conditions | Yield |
---|---|
With sodium carbonate In water at 20℃; for 3h; pH=9 - 10; Green chemistry; | 85% |
Conditions | Yield |
---|---|
With sodium carbonate In water at 20℃; for 3h; pH=9 - 10; Green chemistry; | 85% |
Conditions | Yield |
---|---|
With sodium carbonate In water at 20℃; for 3h; pH=9 - 10; Green chemistry; | 85% |
benzenesulfonyl chloride
paroxetine
Conditions | Yield |
---|---|
With sodium carbonate In water at 20℃; for 3h; pH=9 - 10; Green chemistry; | 85% |
Conditions | Yield |
---|---|
With sodium carbonate In water at 20℃; for 3h; pH=9 - 10; Green chemistry; | 85% |
Conditions | Yield |
---|---|
With sodium carbonate In water at 20℃; for 3h; pH=9 - 10; Green chemistry; | 85% |
4-Acetylbenzenesulfonyl chloride
paroxetine
Conditions | Yield |
---|---|
With sodium carbonate In water at 20℃; for 3h; pH=9 - 10; Green chemistry; | 85% |
carbon dioxide
paroxetine
N-formyl paroxetine ((3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carbaldehyde)
Conditions | Yield |
---|---|
With cyclopentadienyl iron(II) dicarbonyl dimer; tributylphosphine; phenylsilane In acetonitrile at 30℃; under 760.051 Torr; for 36h; Schlenk technique; Sealed tube; | 85% |
paroxetine
Conditions | Yield |
---|---|
With [(N,N’-bis(1R,2R,3R,5S)-(−)-isopinocampheyl-1,2-ethanediimine-radical)NiI(μ2-H)]2; deuterium at -196 - 80℃; under 760.051 Torr; for 24h; Reagent/catalyst; Sealed tube; | 81% |
p-acetylaminobenzenesulfonyl chloride
paroxetine
Conditions | Yield |
---|---|
With sodium carbonate In water at 20℃; for 3h; pH=9 - 10; Green chemistry; | 75% |
Conditions | Yield |
---|---|
With copper(l) iodide; oxygen In 1,2-dichloro-ethane at 100℃; for 24h; Schlenk technique; | 73% |
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