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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Paroxetine

Cas:61869-08-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Paroxetine

Cas:61869-08-7

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Paroxetine 61869-08-7 GMP Manufacturer

Cas:61869-08-7

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Paroxetine

Cas:61869-08-7

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

tianfu-chem_Paroxetine 61869-08-7

Cas:61869-08-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Paroxetine

Cas:61869-08-7

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 61869-08-7 with fast shipping

Cas:61869-08-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

Paroxetine CAS61869-08-7

Cas:61869-08-7

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Synonyms: Paroxetine Molecular Formula: C19H20FNO3 Molecular Weight: 329.37 CAS No.:

Paroxetine

Cas:61869-08-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Piperidine,3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S,4R)- 61869-08-7

Cas:61869-08-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Paroxetine CAS:61869-08-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Paroxetine CAS:61869-08-7

Cas:61869-08-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

61869-08-7 Paroxetine

Cas:61869-08-7

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Paroxetine base

Cas:61869-08-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Piperidine,3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-, (3S,4R)-

Cas:61869-08-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

Q1: Are you a manufacturer?Answer: Yes, we are factory founded on 2002. Q2: How to contact with us?Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours. Q3:Which kind of payment terms do yo

Factory supply Paroxetine powder with best price

Cas:61869-08-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Paroxetine

Cas:61869-08-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater

Paroxetine

Cas:61869-08-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Paroxetine

Cas:61869-08-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Paroxetine

Cas:61869-08-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hefei Zhaobo Technology Co., Ltd.

Paroxetine cas 61869-08-7 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control syste

Paroxetine cas 61869-08-7

Cas:61869-08-7

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Paroxetine

Cas:61869-08-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply paroxetine

Cas:61869-08-7

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products Paroxetine

Cas:61869-08-7

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Wuhan Xinhao Biotechnology Co., Ltd.

1. We can provide customers with "one-stop"packaging service,from research,development,production,export and so on 2. Powerful R&D strength let our technology in a leading level,forever,in turn,to provide customers with better service .

Supply 99.8%Pure Paroxetine Powder, USP Standard 61869-08-7

Cas:61869-08-7

Min.Order:100 Gram

FOB Price: $10.0 / 100.0

Type:Trading Company

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Paroxetine

Cas:61869-08-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Paroxetine

Cas:61869-08-7

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Paroxetine Manufacturer/High quality/Best price/In stock

Cas:61869-08-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Paroxetine

Cas:61869-08-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Paroxetine

Cas:61869-08-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Paroxetine

Cas:61869-08-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

C25H25FN2O3

C25H25FN2O3

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
With acetic acid; zinc at 20℃; for 6h;98%
With acetic acid; zinc at 20℃; for 6h;96%
(3S,4R)-1-benzyl-4-(4-fluorophenyl)-3-[3,4-(methylenedioxy)-phenoxymethyl]piperidine
105813-14-7

(3S,4R)-1-benzyl-4-(4-fluorophenyl)-3-[3,4-(methylenedioxy)-phenoxymethyl]piperidine

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen; acetic acid; isopropyl alcohol at 50℃; under 4500.45 Torr; for 15h; stereoselective reaction;97%
With hydrogen; palladium on activated charcoal In acetic acid; isopropyl alcohol at 50℃; under 4500.36 Torr; for 15h;96%
With palladium on activated charcoal; hydrogen; acetic acid In isopropyl alcohol92%
Stage #1: (3S,4R)-1-benzyl-4-(4-fluorophenyl)-3-[3,4-(methylenedioxy)-phenoxymethyl]piperidine With 1-chloroethyl chloroformate In 1,2-dichloro-ethane for 3h; Heating;
Stage #2: In methanol for 2h; Heating;
54%
(3S,4R)-4-(4-fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)-1-vinyloxycarbonylpiperidine
600135-90-8

(3S,4R)-4-(4-fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)-1-vinyloxycarbonylpiperidine

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Stage #1: (3S,4R)-4-(4-fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)-1-vinyloxycarbonylpiperidine With hydrogenchloride In 1,2-dichloro-ethane for 0.75h;
Stage #2: In ethanol for 1.5h; Heating;
96%
(S)-5-(benzo[1,3]dioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidin-2-one
754183-64-7

(S)-5-(benzo[1,3]dioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidin-2-one

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In diethyl ether at 0 - 20℃;90%
(3S,4R)-1-(tert-butoxycarbonyl)-4-(p-fluorophenyl)-3-[3,4-(methylenedioxy)phenoxymethyl]piperidine
200572-35-6

(3S,4R)-1-(tert-butoxycarbonyl)-4-(p-fluorophenyl)-3-[3,4-(methylenedioxy)phenoxymethyl]piperidine

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; for 0.333333h;75%
With trifluoroacetic acid In dichloromethane at 20℃; for 0.25h; Boc-deprotection;72%
With trifluoroacetic acid In dichloromethane for 0.25h;99 mg
(3R,4S)-5-amino-4-((benzo[d][1,3]dioxol-5-yloxy)methyl)-3-(4-fluorophenyl)pentan-1-ol
1561215-70-0

(3R,4S)-5-amino-4-((benzo[d][1,3]dioxol-5-yloxy)methyl)-3-(4-fluorophenyl)pentan-1-ol

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 20℃; for 2.5h; Inert atmosphere;71%
(3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-1-(phenylsulfonyl)piperidine

(3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-1-(phenylsulfonyl)piperidine

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
With pyrrolidine; samarium diiodide In tetrahydrofuran; water at 20℃; for 0.0833333h;61%
(3S,4R)-3-(Benzo[1,3]dioxol-5-yloxymethyl)-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid methyl ester
200114-10-9

(3S,4R)-3-(Benzo[1,3]dioxol-5-yloxymethyl)-4-(4-fluoro-phenyl)-piperidine-1-carboxylic acid methyl ester

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 110℃; for 42h;61%
(3S,4R)-1-(tert-butoxycarbonyl)-4-(p-fluorophenyl)-3-[3,4-(methylenedioxy)phenoxymethyl]piperidine
200572-35-6

(3S,4R)-1-(tert-butoxycarbonyl)-4-(p-fluorophenyl)-3-[3,4-(methylenedioxy)phenoxymethyl]piperidine

B

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane for 1.5h; Title compound not separated from byproducts.;
(3S,4R)-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid methyl ester
216690-18-5

(3S,4R)-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid methyl ester

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: LiAlH4 / tetrahydrofuran / 20 h / Heating
2.1: 100 percent / Et3N / CH2Cl2 / 0 - 20 °C
3.1: NaH / dimethylformamide / 0.33 h / 20 °C
3.2: 52 percent / dimethylformamide / 14 h / 90 °C
4.1: 96 percent / hydrogen / Pd/C / acetic acid; propan-2-ol / 15 h / 50 °C / 4500.36 Torr
View Scheme
Sesamol
533-31-3

Sesamol

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaH / dimethylformamide / 0.33 h / 20 °C
1.2: 52 percent / dimethylformamide / 14 h / 90 °C
2.1: 96 percent / hydrogen / Pd/C / acetic acid; propan-2-ol / 15 h / 50 °C / 4500.36 Torr
View Scheme
Multi-step reaction with 3 steps
1.1: 80 percent / NaH / dimethylformamide / 4 h / Heating
2.1: 75 percent / potassium carbonate / 1,2-dichloro-ethane / 4 h / Heating
3.1: hydrogen chloride / 1,2-dichloro-ethane / 0.75 h
3.2: 96 percent / ethanol / 1.5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 76 mg / NaOMe / methanol / 1.5 h / Heating
2: 72 percent / TFA / CH2Cl2 / 0.25 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 10 h / 85 °C / Inert atmosphere
2.1: 9-borabicyclo[3.3.1]nonane dimer / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
2.2: 1 h / 20 °C / Inert atmosphere
3.1: hydrazine hydrate / ethanol / 0.58 h / 20 - 85 °C / Inert atmosphere
4.1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 2.5 h / 20 °C / Inert atmosphere
View Scheme
(3S,4R)-[1-benzyl-4-piperidin-3-yl-4-(4-fluorophenyl)]methanol
201855-60-9

(3S,4R)-[1-benzyl-4-piperidin-3-yl-4-(4-fluorophenyl)]methanol

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 100 percent / Et3N / CH2Cl2 / 0 - 20 °C
2.1: NaH / dimethylformamide / 0.33 h / 20 °C
2.2: 52 percent / dimethylformamide / 14 h / 90 °C
3.1: 96 percent / hydrogen / Pd/C / acetic acid; propan-2-ol / 15 h / 50 °C / 4500.36 Torr
View Scheme
Multi-step reaction with 3 steps
1.1: pyridine / 1 h / 10 °C
2.1: 81 mg / NaOMe / methanol / Heating
3.1: 1-chloroethyl formate / 1,2-dichloro-ethane / 3 h / Heating
3.2: 54 percent / methanol / 2 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / toluene
2: sodium hydride / N,N-dimethyl-formamide
3: palladium on activated charcoal; hydrogen; acetic acid / isopropyl alcohol
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 0.33 h / 0 - 20 °C / Inert atmosphere
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C / Inert atmosphere
2.2: 15 h / 90 °C / Inert atmosphere
3.1: acetic acid; palladium 10% on activated carbon; isopropyl alcohol; hydrogen / 15 h / 50 °C / 4500.45 Torr
View Scheme
Methanesulfonic acid (3S,4R)-1-benzyl-4-(4-fluoro-phenyl)-piperidin-3-ylmethyl ester
201855-71-2

Methanesulfonic acid (3S,4R)-1-benzyl-4-(4-fluoro-phenyl)-piperidin-3-ylmethyl ester

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: NaH / dimethylformamide / 0.33 h / 20 °C
1.2: 52 percent / dimethylformamide / 14 h / 90 °C
2.1: 96 percent / hydrogen / Pd/C / acetic acid; propan-2-ol / 15 h / 50 °C / 4500.36 Torr
View Scheme
Multi-step reaction with 2 steps
1.1: 81 mg / NaOMe / methanol / Heating
2.1: 1-chloroethyl formate / 1,2-dichloro-ethane / 3 h / Heating
2.2: 54 percent / methanol / 2 h / Heating
View Scheme
1-(phenylmethyl)-4-(4-fluorophenyl)piperidin-2,6-dione
511283-91-3

1-(phenylmethyl)-4-(4-fluorophenyl)piperidin-2,6-dione

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: chiral bis-lithium amide base / tetrahydrofuran; hexane / 0.75 h / -78 °C
1.2: 71 percent / tetrahydrofuran; hexane / -40 °C
2.1: LiAlH4 / tetrahydrofuran / Heating
3.1: pyridine / 1 h / 10 °C
4.1: 81 mg / NaOMe / methanol / Heating
5.1: 1-chloroethyl formate / 1,2-dichloro-ethane / 3 h / Heating
5.2: 54 percent / methanol / 2 h / Heating
View Scheme
(3S,4R)-1-benzyl-4-(4-fluorophenyl)-2,6-dioxopiperidine-3-carboxylic acid methyl ester
511284-07-4

(3S,4R)-1-benzyl-4-(4-fluorophenyl)-2,6-dioxopiperidine-3-carboxylic acid methyl ester

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: LiAlH4 / tetrahydrofuran / Heating
2.1: pyridine / 1 h / 10 °C
3.1: 81 mg / NaOMe / methanol / Heating
4.1: 1-chloroethyl formate / 1,2-dichloro-ethane / 3 h / Heating
4.2: 54 percent / methanol / 2 h / Heating
View Scheme
3-chloro-4'-fluoropropiophenone
347-93-3

3-chloro-4'-fluoropropiophenone

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 77 percent / Et3N / tetrahydrofuran / 4 h / Heating
2: Na2CO3 / CH2Cl2 / 0.5 h
3: 8.36 g / EtONa / ethanol / 0.5 h / Heating
4: 89 percent / CuCl2; t-BuONa; (R)-p-tolBINAP / PMHS; tert-amyl alcohol / fluorobenzene / 0.75 h
5: 79 percent / MeOH; NaH / toluene / 4 h / Heating
6: 98 percent / BH3 / tetrahydrofuran / 18 h / Heating
7: CAN / acetonitrile; H2O / 0.5 h / 20 °C
8: 268 mg / NaOH / toluene; H2O / 3 h / 20 °C
9: Cs2CO3 / o-xylene / 20 h / 130 °C
10: 99 mg / TFA / CH2Cl2 / 0.25 h
View Scheme
1-(4-fluorophenyl)-3-(4-methoxyphenylamino)propan-1-one
37155-08-1

1-(4-fluorophenyl)-3-(4-methoxyphenylamino)propan-1-one

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: Na2CO3 / CH2Cl2 / 0.5 h
2: 8.36 g / EtONa / ethanol / 0.5 h / Heating
3: 89 percent / CuCl2; t-BuONa; (R)-p-tolBINAP / PMHS; tert-amyl alcohol / fluorobenzene / 0.75 h
4: 79 percent / MeOH; NaH / toluene / 4 h / Heating
5: 98 percent / BH3 / tetrahydrofuran / 18 h / Heating
6: CAN / acetonitrile; H2O / 0.5 h / 20 °C
7: 268 mg / NaOH / toluene; H2O / 3 h / 20 °C
8: Cs2CO3 / o-xylene / 20 h / 130 °C
9: 99 mg / TFA / CH2Cl2 / 0.25 h
View Scheme
(3S,4R)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester
200572-33-4

(3S,4R)-4-(4-fluorophenyl)-3-hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Cs2CO3 / o-xylene / 20 h / 130 °C
2: 99 mg / TFA / CH2Cl2 / 0.25 h
View Scheme
Multi-step reaction with 3 steps
1: Et3N / CH2Cl2 / 0.17 h / 20 °C
2: 0.127 g / NaH / dimethylformamide / 0.25 h / Heating
3: TFA / CH2Cl2 / 1.5 h
View Scheme
Multi-step reaction with 3 steps
1: 100 mg / pyridine / 1 h / 10 °C
2: 76 mg / NaOMe / methanol / 1.5 h / Heating
3: 72 percent / TFA / CH2Cl2 / 0.25 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 1.5 h / 20 °C
2: sodium hydride / tetrahydrofuran; mineral oil / 6 h / 20 °C / Reflux
3: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C
View Scheme
(3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethylpiperidine
125224-43-3

(3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethylpiperidine

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 268 mg / NaOH / toluene; H2O / 3 h / 20 °C
2: Cs2CO3 / o-xylene / 20 h / 130 °C
3: 99 mg / TFA / CH2Cl2 / 0.25 h
View Scheme
4-(4-fluorophenyl)-1-(4-methoxyphenyl)-5,6-dihydro-1H-pyridin-2-one
607375-32-6

4-(4-fluorophenyl)-1-(4-methoxyphenyl)-5,6-dihydro-1H-pyridin-2-one

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 89 percent / CuCl2; t-BuONa; (R)-p-tolBINAP / PMHS; tert-amyl alcohol / fluorobenzene / 0.75 h
2: 79 percent / MeOH; NaH / toluene / 4 h / Heating
3: 98 percent / BH3 / tetrahydrofuran / 18 h / Heating
4: CAN / acetonitrile; H2O / 0.5 h / 20 °C
5: 268 mg / NaOH / toluene; H2O / 3 h / 20 °C
6: Cs2CO3 / o-xylene / 20 h / 130 °C
7: 99 mg / TFA / CH2Cl2 / 0.25 h
View Scheme
(4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-piperidin-2-one
607375-33-7

(4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-piperidin-2-one

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 79 percent / MeOH; NaH / toluene / 4 h / Heating
2: 98 percent / BH3 / tetrahydrofuran / 18 h / Heating
3: CAN / acetonitrile; H2O / 0.5 h / 20 °C
4: 268 mg / NaOH / toluene; H2O / 3 h / 20 °C
5: Cs2CO3 / o-xylene / 20 h / 130 °C
6: 99 mg / TFA / CH2Cl2 / 0.25 h
View Scheme
[(3S,4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-piperidin-3-yl]methanol
607375-35-9

[(3S,4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-piperidin-3-yl]methanol

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: CAN / acetonitrile; H2O / 0.5 h / 20 °C
2: 268 mg / NaOH / toluene; H2O / 3 h / 20 °C
3: Cs2CO3 / o-xylene / 20 h / 130 °C
4: 99 mg / TFA / CH2Cl2 / 0.25 h
View Scheme
(3S,4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-2-oxopiperidin-3-carboxylic acid methyl ester
607375-34-8

(3S,4R)-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-2-oxopiperidin-3-carboxylic acid methyl ester

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 98 percent / BH3 / tetrahydrofuran / 18 h / Heating
2: CAN / acetonitrile; H2O / 0.5 h / 20 °C
3: 268 mg / NaOH / toluene; H2O / 3 h / 20 °C
4: Cs2CO3 / o-xylene / 20 h / 130 °C
5: 99 mg / TFA / CH2Cl2 / 0.25 h
View Scheme
N-[3-(4-fluoro-phenyl)-3-oxo-propyl]-N-(4-methoxy-phenyl)-malonamic acid ethyl ester
1027570-33-7

N-[3-(4-fluoro-phenyl)-3-oxo-propyl]-N-(4-methoxy-phenyl)-malonamic acid ethyl ester

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 8.36 g / EtONa / ethanol / 0.5 h / Heating
2: 89 percent / CuCl2; t-BuONa; (R)-p-tolBINAP / PMHS; tert-amyl alcohol / fluorobenzene / 0.75 h
3: 79 percent / MeOH; NaH / toluene / 4 h / Heating
4: 98 percent / BH3 / tetrahydrofuran / 18 h / Heating
5: CAN / acetonitrile; H2O / 0.5 h / 20 °C
6: 268 mg / NaOH / toluene; H2O / 3 h / 20 °C
7: Cs2CO3 / o-xylene / 20 h / 130 °C
8: 99 mg / TFA / CH2Cl2 / 0.25 h
View Scheme
(3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine
105812-81-5

(3S,4R)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 89 percent / trimethylamine hydrochloride / CH2Cl2 / 4 h / cooling
2.1: 80 percent / NaH / dimethylformamide / 4 h / Heating
3.1: 75 percent / potassium carbonate / 1,2-dichloro-ethane / 4 h / Heating
4.1: hydrogen chloride / 1,2-dichloro-ethane / 0.75 h
4.2: 96 percent / ethanol / 1.5 h / Heating
View Scheme
(3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidine
110429-36-2

(3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidine

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 75 percent / potassium carbonate / 1,2-dichloro-ethane / 4 h / Heating
2.1: hydrogen chloride / 1,2-dichloro-ethane / 0.75 h
2.2: 96 percent / ethanol / 1.5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: toluene / 3.75 h / 100 - 105 °C / Large scale reaction
1.2: 1 h / 60 °C
1.3: 25 - 35 °C
2.1: water; sodium hydroxide / isopropyl alcohol / 82 - 85 °C / Large scale reaction
View Scheme
(3S,4R)-trans-4-(4-fluorophenyl)-1-methyl-3-p-toluenesulphonyloxymethyl-piperidine
317323-77-6

(3S,4R)-trans-4-(4-fluorophenyl)-1-methyl-3-p-toluenesulphonyloxymethyl-piperidine

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 80 percent / NaH / dimethylformamide / 4 h / Heating
2.1: 75 percent / potassium carbonate / 1,2-dichloro-ethane / 4 h / Heating
3.1: hydrogen chloride / 1,2-dichloro-ethane / 0.75 h
3.2: 96 percent / ethanol / 1.5 h / Heating
View Scheme
(3S,4R)-tert-butyl 4-(4-fluorophenyl)-3-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate
200572-34-5

(3S,4R)-tert-butyl 4-(4-fluorophenyl)-3-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 0.127 g / NaH / dimethylformamide / 0.25 h / Heating
2: TFA / CH2Cl2 / 1.5 h
View Scheme
Multi-step reaction with 2 steps
1: 76 mg / NaOMe / methanol / 1.5 h / Heating
2: 72 percent / TFA / CH2Cl2 / 0.25 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium hydride / tetrahydrofuran; mineral oil / 6 h / 20 °C / Reflux
2: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C
View Scheme
(3R,4S)-3-(4-Fluoro-phenyl)-4-nitromethyl-5-triisopropylsilanyloxy-pentanal

(3R,4S)-3-(4-Fluoro-phenyl)-4-nitromethyl-5-triisopropylsilanyloxy-pentanal

paroxetine
61869-08-7

paroxetine

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 0.761 g / NaBH4 / methanol / 1 h
2: ammonium formate / Pd/C / methanol / 0.5 h / Heating
3: 0.702 g / CH2Cl2 / 2 h / 20 °C
4: Et3N / tetrahydrofuran / 0.17 h / 20 °C
5: KOt-Bu / tetrahydrofuran / 0.5 h / 0 °C
6: 0.327 g / TBAF / tetrahydrofuran / 12 h
7: Et3N / CH2Cl2 / 0.17 h / 20 °C
8: 0.127 g / NaH / dimethylformamide / 0.25 h / Heating
9: TFA / CH2Cl2 / 1.5 h
View Scheme
acetic anhydride
108-24-7

acetic anhydride

paroxetine
61869-08-7

paroxetine

N-acetylparoxetine

N-acetylparoxetine

Conditions
ConditionsYield
With triethylamine In acetonitrile at 20℃; for 16h;98%
trifluoroacetic acid
76-05-1

trifluoroacetic acid

paroxetine
61869-08-7

paroxetine

(3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-1-(2,2,2-trifluoroethyl)piperidine

(3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-1-(2,2,2-trifluoroethyl)piperidine

Conditions
ConditionsYield
With potassium phosphate; 18-crown-6 ether; phenylsilane In tetrahydrofuran at 80℃; for 8h; Glovebox; Molecular sieve; Schlenk technique;96%
4-chlorobenzenesulfonyl chloride
98-60-2

4-chlorobenzenesulfonyl chloride

paroxetine
61869-08-7

paroxetine

N-(4-chlorobenzenesulfonyl)paroxetine

N-(4-chlorobenzenesulfonyl)paroxetine

Conditions
ConditionsYield
With sodium carbonate In water at 20℃; for 3h; pH=9 - 10; Green chemistry;90%
propyl bromide
106-94-5

propyl bromide

paroxetine
61869-08-7

paroxetine

C22H26FNO3

C22H26FNO3

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 20℃;88%
formaldehyd
50-00-0

formaldehyd

paroxetine
61869-08-7

paroxetine

(3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidine
110429-36-2

(3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-1-methylpiperidine

Conditions
ConditionsYield
With formic acid; triethylamine In water; tert-butyl alcohol at 100℃; for 14h;87%
paroxetine
61869-08-7

paroxetine

benzenesulfonyl chloride
1939-99-7

benzenesulfonyl chloride

N-(benzylsulphonyl)paroxetine

N-(benzylsulphonyl)paroxetine

Conditions
ConditionsYield
With sodium carbonate In water at 20℃; for 3h; pH=9 - 10; Green chemistry;85%
1-Naphthalenesulfonyl chloride
85-46-1

1-Naphthalenesulfonyl chloride

paroxetine
61869-08-7

paroxetine

N-(naphthalene-1-ylsulfonyl)paroxetine

N-(naphthalene-1-ylsulfonyl)paroxetine

Conditions
ConditionsYield
With sodium carbonate In water at 20℃; for 3h; pH=9 - 10; Green chemistry;85%
2-Naphthalenesulfonyl chloride
93-11-8

2-Naphthalenesulfonyl chloride

paroxetine
61869-08-7

paroxetine

N-(naphthalene-2-ylsulfonyl)paroxetine

N-(naphthalene-2-ylsulfonyl)paroxetine

Conditions
ConditionsYield
With sodium carbonate In water at 20℃; for 3h; pH=9 - 10; Green chemistry;85%
benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

paroxetine
61869-08-7

paroxetine

(3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-1-(phenylsulfonyl)piperidine

(3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-1-(phenylsulfonyl)piperidine

Conditions
ConditionsYield
With sodium carbonate In water at 20℃; for 3h; pH=9 - 10; Green chemistry;85%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

paroxetine
61869-08-7

paroxetine

N-(4-toluenesulfonyl)paroxetine

N-(4-toluenesulfonyl)paroxetine

Conditions
ConditionsYield
With sodium carbonate In water at 20℃; for 3h; pH=9 - 10; Green chemistry;85%
2-mesitylenesulphonyl chloride
773-64-8

2-mesitylenesulphonyl chloride

paroxetine
61869-08-7

paroxetine

N-(2-mesitylenesulfonyl)paroxetine

N-(2-mesitylenesulfonyl)paroxetine

Conditions
ConditionsYield
With sodium carbonate In water at 20℃; for 3h; pH=9 - 10; Green chemistry;85%
4-Acetylbenzenesulfonyl chloride
1788-10-9

4-Acetylbenzenesulfonyl chloride

paroxetine
61869-08-7

paroxetine

N-(4-acetylbenzenesulfonyl)paroxetine

N-(4-acetylbenzenesulfonyl)paroxetine

Conditions
ConditionsYield
With sodium carbonate In water at 20℃; for 3h; pH=9 - 10; Green chemistry;85%
carbon dioxide
124-38-9

carbon dioxide

paroxetine
61869-08-7

paroxetine

N-formyl paroxetine ((3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carbaldehyde)
533935-67-0

N-formyl paroxetine ((3S,4R)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine-1-carbaldehyde)

Conditions
ConditionsYield
With cyclopentadienyl iron(II) dicarbonyl dimer; tributylphosphine; phenylsilane In acetonitrile at 30℃; under 760.051 Torr; for 36h; Schlenk technique; Sealed tube;85%
paroxetine
61869-08-7

paroxetine

C19H14(2)H6FNO3

C19H14(2)H6FNO3

Conditions
ConditionsYield
With [(N,N’-bis(1R,2R,3R,5S)-(−)-isopinocampheyl-1,2-ethanediimine-radical)NiI(μ2-H)]2; deuterium at -196 - 80℃; under 760.051 Torr; for 24h; Reagent/catalyst; Sealed tube;81%
p-acetylaminobenzenesulfonyl chloride
121-60-8

p-acetylaminobenzenesulfonyl chloride

paroxetine
61869-08-7

paroxetine

N-(4-acetamidobenzenesulfonyl)paroxetine

N-(4-acetamidobenzenesulfonyl)paroxetine

Conditions
ConditionsYield
With sodium carbonate In water at 20℃; for 3h; pH=9 - 10; Green chemistry;75%
N-methylmaleimide
930-88-1

N-methylmaleimide

S-methyl thiosulfate O-sodium salt
42254-80-8

S-methyl thiosulfate O-sodium salt

paroxetine
61869-08-7

paroxetine

3-((3R,4S)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidin-1-yl)-1-methyl-4-(methylthio)-1H-pyrrole-2,5-dione

3-((3R,4S)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidin-1-yl)-1-methyl-4-(methylthio)-1H-pyrrole-2,5-dione

Conditions
ConditionsYield
With copper(l) iodide; oxygen In 1,2-dichloro-ethane at 100℃; for 24h; Schlenk technique;73%

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