CAS No.65202-60-0,10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate Suppliers

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6-ethyl-9-methoxycarbonyl-1,4-dioxa-9-azaspiro[4.5]decane-6-carboxylic acid

Cas:65202-60-0

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

Cas:65202-60-0

Min.Order:10 Gram

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

Cas:65202-60-0

Min.Order:1 Kilogram

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists，engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

6-ethyl-9-methoxycarbonyl-1,4-dioxa-9-azaspiro[4.5]decane-6-carboxylic acid

Cas:65202-60-0

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Antimex Chemical Limied

Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin

6-ethyl-9-methoxycarbonyl-1,4-dioxa-9-azaspiro[4.5]decane-6-carboxylic acid

Cas:65202-60-0

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Hangzhou Fandachem Co.,Ltd

65202-60-0 6-ethyl-9-methoxycarbonyl-1,4-dioxa-9-azaspiro[4.5]decane-6-carboxylic acidAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by exp

65202-60-0 6-ethyl-9-methoxycarbonyl-1,4-dioxa-9-azaspiro[4.5]decane-6-carboxylic acid

Cas:65202-60-0

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Chemlyte Solutions

factory?direct?sale Application:Fine chemical intermediates, used as the main raw material for the synthesis of various pesticides, medicines, surfactants, polymer monomers, and antifungal agents

6-ethyl-9-methoxycarbonyl-1,4-dioxa-9-azaspiro[4.5]decane-6-carboxylic acid

Cas:65202-60-0

Min.Order:0

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kingstonchem

6-ethyl-9-methoxycarbonyl-1,4-dioxa-9-azaspiro[4.5]decane-6-carboxylic acid

Cas:65202-60-0

Min.Order:0

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Synthetic route

: 65202-59-7
4-ethyl 1-methyl 3-oxopiperidine-1,4-dicarboxylate

: 107-21-1
ethylene glycol

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 72h; Reflux;	83%
Stage #1: 4-ethyl 1-methyl 3-oxopiperidine-1,4-dicarboxylate; ethylene glycol With toluene-4-sulfonic acid In benzene for 120h; Heating / reflux; Stage #2: With sodium carbonate In water; benzene	83%

: 65202-59-7
4-ethyl 1-methyl 3-oxopiperidine-1,4-dicarboxylate

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In ethylene glycol; ethyl acetate; benzene	65%

: 70637-75-1
ethyl 3-oxopiperidine-4-carboxylate

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium carbonate / 1.5 h / 0 - 20 °C 2: toluene-4-sulfonic acid / benzene / 72 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: potassium carbonate / water / 1.5 h / 0 - 20 °C 2: toluene-4-sulfonic acid / benzene / 120 h / Heating / reflux View Scheme

: 52763-21-0
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogen; palladium 10% on activated carbon / water; ethanol / 48 h / 2327.23 Torr 2: potassium carbonate / 1.5 h / 0 - 20 °C 3: toluene-4-sulfonic acid / benzene / 72 h / Reflux View Scheme
Multi-step reaction with 3 steps 1: hydrogen / palladium 10% on activated carbon / ethanol; water / 48 h / parr shaker 2: potassium carbonate / water / 1.5 h / 0 - 20 °C 3: toluene-4-sulfonic acid / benzene / 120 h / Heating / reflux View Scheme

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

: 1007595-05-2
7-(methoxycarbonyl)-1,4-dioxa-7-azaspiro[4.5]decane-10-carboxylic acid

Conditions

Conditions	Yield
With barium(II) hydroxide In methanol; water at 20℃; for 72h;	93%
Stage #1: 10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate With barium dihydroxide; water In methanol at 20℃; Stage #2: With hydrogenchloride In methanol; water pH=3;	93%

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

: 5470-11-1
hydroxylamine hydrochloride

: 1-methoxycarbonyl-3-oxopiperidine-4-carbohydroxamic acid ethylene acetal

Conditions

Conditions	Yield
With potassium hydroxide; formic acid In methanol; ethanol; acetic acid	29%

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

: 36049-90-8
2-lithio-1,3-dithiane

: 91305-64-5
(1,3-dithian-2-yl)-(1-methoxycarbonyl-3,3-ethylenedioxy-4-piperidyl)-ketone

Conditions

Conditions	Yield
In tetrahydrofuran -78 deg C, 1h; -30 deg C, 1 h; 0 deg C, 1 h;	28%

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

: 91305-67-8
5,6,7,8-tetrahydro-7-methoxycarbonyl-γ-pyrano<6,5-c>pyridine-3-ol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 28 percent / tetrahydrofuran / -78 deg C, 1h; -30 deg C, 1 h; 0 deg C, 1 h 2: 86 percent / 1.) lithiumdiisopropylamine / 1.) -78 deg C, 1 h, 2.) -15 deg C, 1 h 3: 95 percent / conc. HCl / 0.17 h / 70 °C 4: 52 percent / Tl(ONO2)3*3H2O / methanol / 0.17 h / Heating View Scheme

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

: 91305-66-7
2,3,5,6,7,8-hexahydro-7-methoxycarbonyl-3,3-trimethylendithio-γ-pyrano<6,5->pyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 28 percent / tetrahydrofuran / -78 deg C, 1h; -30 deg C, 1 h; 0 deg C, 1 h 2: 86 percent / 1.) lithiumdiisopropylamine / 1.) -78 deg C, 1 h, 2.) -15 deg C, 1 h 3: 95 percent / conc. HCl / 0.17 h / 70 °C View Scheme

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

: 91305-65-6
(2-hydroxymethyl-1,3-dithian-2-yl)-(1-methoxycarbonyl-3,3-ethylenedioxy-4-piperidyl)-ketone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 28 percent / tetrahydrofuran / -78 deg C, 1h; -30 deg C, 1 h; 0 deg C, 1 h 2: 86 percent / 1.) lithiumdiisopropylamine / 1.) -78 deg C, 1 h, 2.) -15 deg C, 1 h View Scheme

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

: 91305-68-9
5,6,7,8-tetrahydro-γ-pyrano<6,5-c>pyridine-3-ol hydrobromide

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 28 percent / tetrahydrofuran / -78 deg C, 1h; -30 deg C, 1 h; 0 deg C, 1 h 2: 86 percent / 1.) lithiumdiisopropylamine / 1.) -78 deg C, 1 h, 2.) -15 deg C, 1 h 3: 95 percent / conc. HCl / 0.17 h / 70 °C 4: 52 percent / Tl(ONO2)3*3H2O / methanol / 0.17 h / Heating 5: 91 percent / HBr / acetic acid / 14 h / Ambient temperature View Scheme

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

: 1007595-18-7
methyl 10-{[(benzyloxy)carbonyl]amino}-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: barium(II) hydroxide / water; methanol / 72 h / 20 °C 2: triethylamine / acetone / 1 h / 0 °C 3: sodium azide / water; acetone / 4.5 h / 0 - 20 °C 4: toluene / Dean-Stark; Reflux View Scheme
Multi-step reaction with 2 steps 1.1: barium dihydroxide; water / methanol / 20 °C 1.2: pH 3 2.1: triethylamine / acetone / 1 h / 0 °C 2.2: 0 - 20 °C 2.3: Heating / reflux View Scheme

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

: C10H14N2O5

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: barium(II) hydroxide / water; methanol / 72 h / 20 °C 2: triethylamine / acetone / 1 h / 0 °C 3: sodium azide / water; acetone / 4.5 h / 0 - 20 °C View Scheme

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

: C13H19NO8

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: barium(II) hydroxide / water; methanol / 72 h / 20 °C 2: triethylamine / acetone / 1 h / 0 °C View Scheme

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

: 1007595-29-0
methyl 10-amino-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: barium(II) hydroxide / water; methanol / 72 h / 20 °C 2: triethylamine / acetone / 1 h / 0 °C 3: sodium azide / water; acetone / 4.5 h / 0 - 20 °C 4: toluene / Dean-Stark; Reflux 5: hydrogen; palladium 10% on activated carbon / ethanol / Inert atmosphere View Scheme
Multi-step reaction with 3 steps 1.1: barium dihydroxide; water / methanol / 20 °C 1.2: pH 3 2.1: triethylamine / acetone / 1 h / 0 °C 2.2: 0 - 20 °C 2.3: Heating / reflux 3.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C View Scheme

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

: 1007595-38-1
methyl 10-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}-1,4-dioxa-7-azaspiro[4.5]decane-7-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: barium(II) hydroxide / water; methanol / 72 h / 20 °C 2: triethylamine / acetone / 1 h / 0 °C 3: sodium azide / water; acetone / 4.5 h / 0 - 20 °C 4: toluene / Dean-Stark; Reflux 5: hydrogen; palladium 10% on activated carbon / ethanol / Inert atmosphere 6: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C View Scheme
Multi-step reaction with 4 steps 1.1: barium dihydroxide; water / methanol / 20 °C 1.2: pH 3 2.1: triethylamine / acetone / 1 h / 0 °C 2.2: 0 - 20 °C 2.3: Heating / reflux 3.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C 4.1: 4-methyl-morpholine; benzotriazol-1-ol / dichloromethane / 1 h / 20 °C 4.2: 12 h / 20 °C View Scheme

Yield

Multi-step reaction with 6 steps
1: barium(II) hydroxide / water; methanol / 72 h / 20 °C
2: triethylamine / acetone / 1 h / 0 °C
3: sodium azide / water; acetone / 4.5 h / 0 - 20 °C
4: toluene / Dean-Stark; Reflux
5: hydrogen; palladium 10% on activated carbon / ethanol / Inert atmosphere
6: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C
View Scheme

Multi-step reaction with 4 steps
1.1: barium dihydroxide; water / methanol / 20 °C
1.2: pH 3
2.1: triethylamine / acetone / 1 h / 0 °C
2.2: 0 - 20 °C
2.3: Heating / reflux
3.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C
4.1: 4-methyl-morpholine; benzotriazol-1-ol / dichloromethane / 1 h / 20 °C
4.2: 12 h / 20 °C
View Scheme

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

: 1007589-38-9
3,4-dichloro-N-1,4-dioxa-7-azaspiro[4.5]dec-10-yl-5-methyl-1H-pyrrole-2-carboxamide

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: barium(II) hydroxide / water; methanol / 72 h / 20 °C 2: triethylamine / acetone / 1 h / 0 °C 3: sodium azide / water; acetone / 4.5 h / 0 - 20 °C 4: toluene / Dean-Stark; Reflux 5: hydrogen; palladium 10% on activated carbon / ethanol / Inert atmosphere 6: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C 7: barium(II) hydroxide / water; ethanol / 2 h / 130 °C / Microwave irradiation View Scheme
Multi-step reaction with 5 steps 1.1: barium dihydroxide; water / methanol / 20 °C 1.2: pH 3 2.1: triethylamine / acetone / 1 h / 0 °C 2.2: 0 - 20 °C 2.3: Heating / reflux 3.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C 4.1: 4-methyl-morpholine; benzotriazol-1-ol / dichloromethane / 1 h / 20 °C 4.2: 12 h / 20 °C 5.1: barium dihydroxide; water / methanol / 2 h / 130 °C / microwave irradiation View Scheme

Yield

Multi-step reaction with 7 steps
1: barium(II) hydroxide / water; methanol / 72 h / 20 °C
2: triethylamine / acetone / 1 h / 0 °C
3: sodium azide / water; acetone / 4.5 h / 0 - 20 °C
4: toluene / Dean-Stark; Reflux
5: hydrogen; palladium 10% on activated carbon / ethanol / Inert atmosphere
6: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C
7: barium(II) hydroxide / water; ethanol / 2 h / 130 °C / Microwave irradiation
View Scheme

Multi-step reaction with 5 steps
1.1: barium dihydroxide; water / methanol / 20 °C
1.2: pH 3
2.1: triethylamine / acetone / 1 h / 0 °C
2.2: 0 - 20 °C
2.3: Heating / reflux
3.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C
4.1: 4-methyl-morpholine; benzotriazol-1-ol / dichloromethane / 1 h / 20 °C
4.2: 12 h / 20 °C
5.1: barium dihydroxide; water / methanol / 2 h / 130 °C / microwave irradiation
View Scheme

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

: 2-[6-[(3,4-dichloro-5-methyl-1H-pyrrole-2-carbonyl)amino]-1,4-dioxa-9-azaspiro[4.5]decan-9-yl]thiazole-5-carboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 9 steps 1: barium(II) hydroxide / water; methanol / 72 h / 20 °C 2: triethylamine / acetone / 1 h / 0 °C 3: sodium azide / water; acetone / 4.5 h / 0 - 20 °C 4: toluene / Dean-Stark; Reflux 5: hydrogen; palladium 10% on activated carbon / ethanol / Inert atmosphere 6: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C 7: barium(II) hydroxide / water; ethanol / 2 h / 130 °C / Microwave irradiation 8: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / Microwave irradiation 9: barium(II) hydroxide / water; methanol / 3 h View Scheme
Multi-step reaction with 7 steps 1.1: barium dihydroxide; water / methanol / 20 °C 1.2: pH 3 2.1: triethylamine / acetone / 1 h / 0 °C 2.2: 0 - 20 °C 2.3: Heating / reflux 3.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C 4.1: 4-methyl-morpholine; benzotriazol-1-ol / dichloromethane / 1 h / 20 °C 4.2: 12 h / 20 °C 5.1: barium dihydroxide; water / methanol / 2 h / 130 °C / microwave irradiation 6.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.5 h / 80 °C / microwave irradiation 7.1: barium dihydroxide; water / methanol / 2 h / 60 °C 7.2: 20 °C View Scheme

Yield

Multi-step reaction with 9 steps
1: barium(II) hydroxide / water; methanol / 72 h / 20 °C
2: triethylamine / acetone / 1 h / 0 °C
3: sodium azide / water; acetone / 4.5 h / 0 - 20 °C
4: toluene / Dean-Stark; Reflux
5: hydrogen; palladium 10% on activated carbon / ethanol / Inert atmosphere
6: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C
7: barium(II) hydroxide / water; ethanol / 2 h / 130 °C / Microwave irradiation
8: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / Microwave irradiation
9: barium(II) hydroxide / water; methanol / 3 h
View Scheme

Multi-step reaction with 7 steps
1.1: barium dihydroxide; water / methanol / 20 °C
1.2: pH 3
2.1: triethylamine / acetone / 1 h / 0 °C
2.2: 0 - 20 °C
2.3: Heating / reflux
3.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C
4.1: 4-methyl-morpholine; benzotriazol-1-ol / dichloromethane / 1 h / 20 °C
4.2: 12 h / 20 °C
5.1: barium dihydroxide; water / methanol / 2 h / 130 °C / microwave irradiation
6.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.5 h / 80 °C / microwave irradiation
7.1: barium dihydroxide; water / methanol / 2 h / 60 °C
7.2: 20 °C
View Scheme

: 65202-60-0
10-ethyl 7-methyl 1,4-dioxa-7-azaspiro[4.5]decane-7,10-dicarboxylate

: methyl 2-[6-[(3,4-dichloro-5-methyl-1H-pyrrole-2-carbonyl)amino]-1,4-dioxa-9-azaspiro[4.5]decan-9-yl]thiazole-5-carboxylate

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1: barium(II) hydroxide / water; methanol / 72 h / 20 °C 2: triethylamine / acetone / 1 h / 0 °C 3: sodium azide / water; acetone / 4.5 h / 0 - 20 °C 4: toluene / Dean-Stark; Reflux 5: hydrogen; palladium 10% on activated carbon / ethanol / Inert atmosphere 6: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C 7: barium(II) hydroxide / water; ethanol / 2 h / 130 °C / Microwave irradiation 8: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / Microwave irradiation View Scheme
Multi-step reaction with 6 steps 1.1: barium dihydroxide; water / methanol / 20 °C 1.2: pH 3 2.1: triethylamine / acetone / 1 h / 0 °C 2.2: 0 - 20 °C 2.3: Heating / reflux 3.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C 4.1: 4-methyl-morpholine; benzotriazol-1-ol / dichloromethane / 1 h / 20 °C 4.2: 12 h / 20 °C 5.1: barium dihydroxide; water / methanol / 2 h / 130 °C / microwave irradiation 6.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.5 h / 80 °C / microwave irradiation View Scheme

Yield

Multi-step reaction with 8 steps
1: barium(II) hydroxide / water; methanol / 72 h / 20 °C
2: triethylamine / acetone / 1 h / 0 °C
3: sodium azide / water; acetone / 4.5 h / 0 - 20 °C
4: toluene / Dean-Stark; Reflux
5: hydrogen; palladium 10% on activated carbon / ethanol / Inert atmosphere
6: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C
7: barium(II) hydroxide / water; ethanol / 2 h / 130 °C / Microwave irradiation
8: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / Microwave irradiation
View Scheme

Multi-step reaction with 6 steps
1.1: barium dihydroxide; water / methanol / 20 °C
1.2: pH 3
2.1: triethylamine / acetone / 1 h / 0 °C
2.2: 0 - 20 °C
2.3: Heating / reflux
3.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C
4.1: 4-methyl-morpholine; benzotriazol-1-ol / dichloromethane / 1 h / 20 °C
4.2: 12 h / 20 °C
5.1: barium dihydroxide; water / methanol / 2 h / 130 °C / microwave irradiation
6.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.5 h / 80 °C / microwave irradiation
View Scheme

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