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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-[(Diphenylmethyl)Thio]Acetamide supplier in China

Cas:68524-30-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product informations Product Name 2-[(Diphenylmethyl)thio]acetamide CAS No. 68524-30-1 Appear

2-[(Diphenylmethyl)thio]acetamide

Cas:68524-30-1

Min.Order:1 Gram

FOB Price: $8.0

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

2-[(Diphenylmethyl)Thio]Acetamide manufacturer/supplier

Cas:68524-30-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-[(Diphenylmethyl)Thio]Acetamide

Cas:68524-30-1

Min.Order:1

Negotiable

Type:Other

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality 2-[(Diphenylmethyl)thio]acetamide

Cas:68524-30-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2-[(Diphenylmethyl)thio]acetamide Manufacturer/High quality/Best price/In stock

Cas:68524-30-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-[(Diphenylmethyl)-mercapto]-acetamide

Cas:68524-30-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

2-[(Diphenylmethyl)thio]acetamide

Cas:68524-30-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Diphenylmethylthioacetamide

Cas:68524-30-1

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

C15H15NOS 2-[(Diphenylmethyl)thio]acetamide 68524-30-1

Cas:68524-30-1

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 68524-30-1 with competitive price

Cas:68524-30-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

2-[(Diphenylmethyl)thio]acetamide CAS68524-30-1

Cas:68524-30-1

Min.Order:1 Kilogram

FOB Price: $7.0 / 9.0

Type:Trading Company

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Hefei TNJ chemical industry co.,ltd

2-[(Diphenylmethyl)thio]acetamide Basic information Product Name: 2-[(Diphenylmethyl)thio]acetamide Synonyms: 2-[(DIPHENYLMETHYL)THIO]-ACETAMIDE;DIPHENYL METHYL THIO ACETAMIDE;2-[(Diphenylmethyl) Thio] Acetylamine;2-[(Diphenylmethyl)thio

Manufacturer of 2-[(Diphenylmethyl)thio]acetamide at Factory Price

Cas:68524-30-1

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Acetamide,2-[(diphenylmethyl)thio]- 68524-30-1

Cas:68524-30-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

2-[(Diphenylmethyl)thio]acetamide Basic information Product Name: 2-[(Diphenylmethyl)thio]acetamide Synonyms: Armodafinil Impurity E (USP RC C);2-[(DIPHENYLMETHYL)THIO]-ACETAMIDE;2-[(Diphenylmethyl) Thio] Acetylamine;2-[(Diphenylmethyl)thio] ac

2-[(Diphenylmethyl)thio]acetamide

Cas:68524-30-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

2-[(Diphenylmethyl)thio]acetamide CAS:68524-30-1

Cas:68524-30-1

Min.Order:1 Kilogram

FOB Price: $81.0 / 94.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

2-[(Diphenylmethyl)thio]acetamide CAS:68524-30-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality

2-[(Diphenylmethyl)thio]acetamide CAS:68524-30-1

Cas:68524-30-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Acetamide,2-[(diphenylmethyl)thio]-

Cas:68524-30-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Acetamide,2-[(diphenylmethyl)thio]-

Cas:68524-30-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Luyunjia Chemistry Xiamen Limited

Overview Quick Details CAS No.: 68524-30-1 Other Names: 2-[(Diphenylmethyl)thio]acetamide CAS 68524-30-1 MF: C15H15NOS, C15H15NOS EINECS No.: 68524-30-1 Place of Origin: Shandong, China (Mainland) Type: Pharmaceutical Intermediates Puri

Diphenylmethylthioacetamide

Cas:68524-30-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-[(Diphenylmethyl)thio]acetamide

Cas:68524-30-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

DIPHENYLMETHYLTHIOACETAMIDE

Cas:68524-30-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-(Diphenylmethyl)thioacetamide

Cas:68524-30-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 2-[(Diphenylmethyl)Thio]Acetamide

Cas:68524-30-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

2-[(Diphenylmethyl)thio]acetamideAppearance:White Crystalline Solid Storage:Protected from light, stored hermetically and in a dry place Package:according to customers' requirements Application:Pharmaceutical Intermediate Transportation:By air(EMS or

2-[(Diphenylmethyl)thio]acetamide

Cas:68524-30-1

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Transp

2-[(Diphenylmethyl)thio]acetamide

Cas:68524-30-1

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: 2-[(Diphenylmethyl)Thio]Acetamide CAS No.:68524-30-1 Molecule Formula:C15H15NOS Molecule Weight:257.35 Purity: 99% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TE

High Quality 2-[(Diphenylmethyl)Thio]Acetamide in stock

Cas:68524-30-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2-[(Diphenylmethyl)thio]acetamide

Cas:68524-30-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

2-[(Diphenylmethyl)thio]acetamide

Cas:68524-30-1

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Hot sale DIPHENYL METHYL THIO ACETAMIDE with lowest price

Cas:68524-30-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Synthetic route

diphenylchloromethane
90-99-3

diphenylchloromethane

Chloroacetamide
79-07-2

Chloroacetamide

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
Stage #1: diphenylchloromethane With thiourea; potassium iodide In water at 70 - 75℃; for 1.5h;
Stage #2: With sodium hydroxide In water at 15 - 24℃;
Stage #3: Chloroacetamide With triethylamine more than 3 stages;
97.9%
Stage #1: diphenylchloromethane With thiourea In isopropyl alcohol at 100℃; for 2h; Sealed tube;
Stage #2: Chloroacetamide With potassium hydroxide In methanol; isopropyl alcohol at 60℃; for 2h; Sonication;
benzhydrylsulfanyl acetyl chloride
68524-29-8

benzhydrylsulfanyl acetyl chloride

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
With ammonium hydroxide In tetrahydrofuran; dichloromethane at 0℃; for 1h;96%
With ammonium hydroxide In dichloromethane for 2h;17.0 g
With ammonium hydroxide In dichloromethane at 2℃; for 20h;
With ammonium hydroxide In dichloromethane; water at 0℃; for 1h;14.39 g
With ammonium hydroxide In water at 0 - 20℃; for 20h; Alkaline conditions;
1,1-Diphenylmethanol
91-01-0

1,1-Diphenylmethanol

sodium S-(carbamoylmethyl)thiosulfate
18877-99-1

sodium S-(carbamoylmethyl)thiosulfate

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
With formic acid In water at 60℃; for 0.333333h;92%
(benzhydrylthio)acetic acid
63547-22-8

(benzhydrylthio)acetic acid

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
With ammonium carbamate; novozyme-435 In tert-butyl alcohol at 60℃; for 168h;90%
Stage #1: (benzhydrylthio)acetic acid With thionyl chloride In benzene for 2h; Reflux;
Stage #2: With ammonia In dichloromethane at 20℃; for 2h; Cooling with ice;
69%
Stage #1: (benzhydrylthio)acetic acid With thionyl chloride In benzene at 20℃; for 1h; Inert atmosphere; Reflux;
Stage #2: With ammonium hydroxide In dichloromethane at 0℃; for 1h;
54%
bromo-acetic acid amide
683-57-8

bromo-acetic acid amide

diphenylmethylisothiouronium bromide
90280-15-2

diphenylmethylisothiouronium bromide

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
Stage #1: diphenylmethylisothiouronium bromide With sodium hydroxide In water at 40 - 80℃;
Stage #2: bromo-acetic acid amide at 60 - 70℃; for 5 - 6h;
90%
diphenylmethylisothiouronium bromide
90280-15-2

diphenylmethylisothiouronium bromide

Chloroacetamide
79-07-2

Chloroacetamide

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
Stage #1: diphenylmethylisothiouronium bromide With sodium hydroxide In water at 40 - 85℃;
Stage #2: Chloroacetamide at 30 - 70℃; for 5 - 6h;
88%
Stage #1: diphenylmethylisothiouronium bromide With sodium hydroxide In methanol; water at 40 - 60℃; for 0.5h;
Stage #2: Chloroacetamide for 3.16667 - 4.16667h; Heating / reflux;
71%
Thioglycolamide
758-08-7

Thioglycolamide

1,1-Diphenylmethanol
91-01-0

1,1-Diphenylmethanol

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
With Nafion-H In 2-methyltetrahydrofuran at 20℃; for 12h; Catalytic behavior; Reagent/catalyst; Solvent; Green chemistry;88%
With trifluoroacetic acid at 20℃; for 4h;17%
With ammonia; trifluoroacetic acid In methanol at 20℃; for 4h;17%
(+)-Modafinil

(+)-Modafinil

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
With acetyl chloride; potassium iodide In acetic acid at 20℃; for 0.5h;87%
triethylamine
121-44-8

triethylamine

diphenylchloromethane
90-99-3

diphenylchloromethane

Chloroacetamide
79-07-2

Chloroacetamide

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
Stage #1: diphenylchloromethane With thiourea; potassium iodide In water at 70 - 95℃; for 2h;
Stage #2: With sodium hydroxide In water at 15 - 24℃;
Stage #3: triethylamine; Chloroacetamide more than 3 stages;
81.4%
2-benzhydrylsulfanylacetonitrile
63547-26-2

2-benzhydrylsulfanylacetonitrile

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
With potassium hydroxide In ethanol for 6h; Reflux;75%
(diphenylmethyl)(ethyl acetate)sulfide
63547-23-9

(diphenylmethyl)(ethyl acetate)sulfide

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
With ammonia at 100℃;
1,1-Diphenylmethanol
91-01-0

1,1-Diphenylmethanol

BF3(C2H5)2O

BF3(C2H5)2O

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 99.9 percent / SOCl2 / benzene / 1 h / Heating
2: 96 percent / NH4OH / CH2Cl2; tetrahydrofuran / 1 h / 0 °C
View Scheme
Multi-step reaction with 2 steps
1: 90 percent / ammonium carbamate; Novozyme-435 / 2-methyl-propan-2-ol / 168 h / 60 °C
View Scheme
Multi-step reaction with 3 steps
1: 99 percent / trifluoroacetic acid / 3 h / 20 °C
2: thionyl chloride / benzene / 1.5 h / Heating
3: 17.0 g / aq. NH4OH / CH2Cl2 / 2 h
View Scheme
1,1-Diphenylmethanol
91-01-0

1,1-Diphenylmethanol

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: concentrated aqueous HCl
2: concentrated sulfuric acid
3: ethanolic NH3 / 100 °C
View Scheme
Multi-step reaction with 3 steps
1: trifluoroacetic acid / 20 °C
2: potassium carbonate / acetone / 4 h / Reflux
3: ammonium hydroxide; ammonium chloride / methanol / 72 h / 50 °C
View Scheme
Multi-step reaction with 3 steps
1: Lawessons reagent / toluene / 3 h / Reflux; Inert atmosphere
2: potassium carbonate / acetone / 6 h
3: potassium hydroxide / ethanol / 6 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: trifluoroacetic acid / 3 h
2: thionyl chloride / benzene / 2 h / Reflux
3: ammonium hydroxide / dichloromethane / 20 h / 2 °C
View Scheme
Multi-step reaction with 2 steps
1.1: trifluoroacetic acid / 3 h / 20 °C
2.1: thionyl chloride / benzene / 2 h / Reflux
2.2: 2 h / 20 °C / Cooling with ice
View Scheme
diphenylmethanethiol
4237-48-3

diphenylmethanethiol

Chloroacetamide
79-07-2

Chloroacetamide

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
In tetrahydrofuran; water at 70℃; for 1.25h;
In water; chlorobenzene at 70℃; for 0.75h;
methyl diphenylmethylmercaptoacetate
118286-24-1

methyl diphenylmethylmercaptoacetate

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
With ammonia In methanol at 15℃; for 1h;
With ammonium hydroxide; ammonium chloride In methanol at 50℃; for 72h;
ammonium carbamate

ammonium carbamate

NH4OH-THF

NH4OH-THF

(benzhydrylthio)acetic acid
63547-22-8

(benzhydrylthio)acetic acid

benzhydrylsulfanyl acetyl chloride
68524-29-8

benzhydrylsulfanyl acetyl chloride

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
With thionyl chloride In dichloromethane; water; tert-butyl alcohol; benzene
Reaxys ID: 19820829

Reaxys ID: 19820829

Reaxys ID: 19820830

Reaxys ID: 19820830

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

diphenylmethanethiol
4237-48-3

diphenylmethanethiol

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / acetone / 6 h
2: potassium hydroxide / ethanol / 6 h / Reflux
View Scheme
Bromodiphenylmethane
776-74-9

Bromodiphenylmethane

2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water; acetone / 3 h / 20 - 70 °C / Inert atmosphere
2: thionyl chloride / benzene / 1 h / Inert atmosphere; Reflux
3: ammonium hydroxide / water; dichloromethane / 1 h / 0 °C
View Scheme
Multi-step reaction with 2 steps
1.1: water; acetone / 3 h / 20 - 70 °C / Inert atmosphere
2.1: thionyl chloride / benzene / 1 h / 20 °C / Inert atmosphere; Reflux
2.2: 1 h / 0 °C
View Scheme
2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Conditions
ConditionsYield
With phthaloyl peroxide In dichloromethane at 25℃; for 8h; Schlenk technique; chemoselective reaction;99%
With 1-methyl-3,5-dinitropyridinium trifluoromethanesulfonate; dihydrogen peroxide In methanol; water at 25℃; for 21.5h; Reagent/catalyst;98%
With 1-octyl-3,5-dinitropyridinium triflate; dihydrogen peroxide In aq. phosphate buffer; chloroform at 25℃; for 4h; pH=2; Reagent/catalyst; Green chemistry; chemoselective reaction;98%
2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

l-modafinil

l-modafinil

Conditions
ConditionsYield
Stage #1: 2-(diphenylmethylthio)acetamide; titanium(IV) isopropylate; diethyl (2R,3R)-tartrate In water; toluene at 55℃; for 0.833333h;
Stage #2: With Cumene hydroperoxide; N-ethyl-N,N-diisopropylamine In water; toluene at 25℃; for 1h; Product distribution / selectivity;
98.5%
Stage #1: 2-(diphenylmethylthio)acetamide; titanium(IV) isopropylate; diethyl (2S,3S)-tartrate In water; toluene at 55℃; for 0.833333h;
Stage #2: With Cumene hydroperoxide; triethylamine In water; toluene at 25℃; for 1h; Product distribution / selectivity;
90.3%
Stage #1: 2-(diphenylmethylthio)acetamide; titanium(IV) isopropylate; diethyl (2S,3S)-tartrate In toluene at 55℃; for 0.833333h;
Stage #2: With Cumene hydroperoxide; N-ethyl-N,N-diisopropylamine In toluene at 25℃; for 1h; Product distribution / selectivity;
90.3%
2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

B

Modafinil sulfone

Modafinil sulfone

Conditions
ConditionsYield
With dihydrogen peroxide In acetic acid at 40℃; for 6h;A 95.73%
B 0.083%
With dihydrogen peroxide; acetic acid In methanol; water at 40 - 65℃; for 1 - 28.75h; Product distribution / selectivity;
2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

2-benzhydrylsulfanylacetonitrile
63547-26-2

2-benzhydrylsulfanylacetonitrile

Conditions
ConditionsYield
With (dimethoxy)methylsilane; copper diacetate; 1,2-bis-(dicyclohexylphosphino)ethane In tetrahydrofuran at 20℃; for 12h; Sealed tube;77%
2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

Modafinil sulfone

Modafinil sulfone

Conditions
ConditionsYield
With ε-phthalimido-peroxy-hexanoic acid In dichloromethane at 20℃; for 6h;72%
2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

2-(benzhydrylthio)ethanethioamide

2-(benzhydrylthio)ethanethioamide

Conditions
ConditionsYield
With Lawessons reagent In 1,4-dioxane for 2h; Reflux;62%
With tetraphosphorus decasulfide; potassium sulfide; toluene
With Lawessons reagent
2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

d-modafinil

d-modafinil

l-modafinil

l-modafinil

Conditions
ConditionsYield
Stage #1: 2-(diphenylmethylthio)acetamide; titanium(IV) isopropylate; diethyl (2R,3R)-tartrate In dichloromethane; water at -30 - 20℃; for 0.833333h;
Stage #2: With Cumene hydroperoxide In dichloromethane; water at -30 - -25℃; for 1.75h; Conversion of starting material;
A 42%
B n/a
Stage #1: 2-(diphenylmethylthio)acetamide; titanium(IV) isopropylate; diethyl (2S,3S)-tartrate In water; ethyl acetate at 25 - 55℃; for 0.166667 - 0.833333h;
Stage #2: With Cumene hydroperoxide; triethylamine In water; ethyl acetate at 25 - 55℃; for 0.0833333 - 1h; Product distribution / selectivity;
A n/a
B n/a
Stage #1: 2-(diphenylmethylthio)acetamide; titanium(IV) isopropylate; diethyl (2S,3S)-tartrate In water; ethyl acetate at 55℃; for 0.833333h;
Stage #2: With Cumene hydroperoxide In water; ethyl acetate at 25℃; for 1h; Product distribution / selectivity;
A n/a
B n/a
Stage #1: 2-(diphenylmethylthio)acetamide; titanium(IV) isopropylate; diethyl (2S,3S)-tartrate In water; toluene at 55℃; for 0.833333h;
Stage #2: With Cumene hydroperoxide In water; toluene at 25℃; for 1h; Product distribution / selectivity;
A n/a
B n/a
2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

2,4,6-tribenzhydrylphenol
6266-48-4

2,4,6-tribenzhydrylphenol

Conditions
ConditionsYield
With trifluoroacetyl peroxide In trifluoroacetic acid at 10℃; for 0.166667h; Mechanism;34%
2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

2-(benzhydrylmercapto-methyl)-4,5-dihydro-1H-imidazole

2-(benzhydrylmercapto-methyl)-4,5-dihydro-1H-imidazole

Conditions
ConditionsYield
With tetraphosphorus decasulfide; potassium sulfide; toluene at 100℃; Erhitzen des Reaktionsprodukts mit Aethylendiamin in Toluol;
2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

B

modafinil acid
63547-24-0

modafinil acid

Conditions
ConditionsYield
Stage #1: 2-(diphenylmethylthio)acetamide With acetic acid In methanol at 30 - 40℃; for 0.25h;
Stage #2: With dihydrogen peroxide In methanol; water at 38 - 43℃; for 24h; Product distribution / selectivity;
2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

B

modafinil acid
63547-24-0

modafinil acid

C

Modafinil sulfone

Modafinil sulfone

Conditions
ConditionsYield
Stage #1: 2-(diphenylmethylthio)acetamide With acetic acid In methanol at 30 - 40℃; for 0.25h;
Stage #2: With dihydrogen peroxide In methanol; water at 38 - 43℃; for 24h; Product distribution / selectivity;
2-(diphenylmethylthio)acetamide
68524-30-1

2-(diphenylmethylthio)acetamide

A

Nuvigil
112111-43-0

Nuvigil

B

(+)-Modafinil

(+)-Modafinil

Conditions
ConditionsYield
With 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate In tetrachloromethane at 20℃; for 48h; Title compound not separated from byproducts.;
With bis(acetylacetonate)oxovanadium; 2,4-di-tert-butyl-6-((E)-(((1R,2S)-2-hydroxy-1,2-diphenylethyl)imino)methyl)phenol; dihydrogen peroxide In chloroform at 20℃; for 3.5h; optical yield given as %ee; enantioselective reaction;
With NADP In isopropyl alcohol at 25℃; for 20h; pH=8; Catalytic behavior; Alkaline conditions; enantioselective reaction;A n/a
B n/a
With tert.-butylhydroperoxide at 20℃; Enzymatic reaction;
Stage #1: 2-(diphenylmethylthio)acetamide With iron(III) trifluoromethanesulfonate; C37H56N4O4 In tert-butyl methyl ether at 35℃; for 0.5h; Inert atmosphere;
Stage #2: With dihydrogen peroxide In tert-butyl methyl ether; water at 25℃; for 8h; Inert atmosphere; Overall yield = 94 percent; Overall yield = 25.6 mg; enantioselective reaction;
A n/a
B n/a

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