Products

Refine

Country

Business Type

Certificate

Display

Hefei Zhaobo Technology Co., Ltd.

Sertraline hydrochloride CAS 79559-97-0 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality

Sertraline hydrochloride CAS 79559-97-0

Cas:79559-97-0

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

kern enterprises

ProName: API Raw Pharmaceutical Material Sertra... CasNo: 79559-97-0 Molecular Formula: C17H18Cl3N Appearance: white powder Application: Pharmaceutical raw intermediates DeliveryTime: Within 5 days after payment PackAge:

Sertraline hydrochloride

Cas:79559-97-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Sertraline hydrochloride Manufacturer/High quality/Best price/In stock

Cas:79559-97-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Sinoway Industrial Co., Ltd.

Sinoway's Advantages: - ISO 9001:2008 certificated company - SGS Audited Company - 26-year experienced in pharmaceutical industry - China office of Fischer Chemicals AG (Switzerland) Appearance:A WHITE CRYSTALLINE POWDER Storage

Sertraline Hydrochloride supplier

Cas:79559-97-0

Min.Order:25 Kilogram

FOB Price: $1000.0

Type:Trading Company

inquiry

Hangzhou Dingyan Chem Co., Ltd

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Hangzhou Dingyan Chem is a leading manufacturer and supplier

High purity Various Specifications Sertraline HCL 79559-97-0

Cas:79559-97-0

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Sertraline HCL manufacturer with low price

Cas:79559-97-0

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White or almost white powder Storage:Desiccate at RT Package:

Good quality Sertraline hydrochloride CAS 79559-97-0 supplied by manufacturer

Cas:79559-97-0

Min.Order:1 Kilogram

FOB Price: $500.0 / 580.0

Type:Trading Company

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

Sertraline hydrochloride

Cas:79559-97-0

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Sertraline hydrochloride 79559-97-0 GMP Manufacturer

Cas:79559-97-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Sertraline hydrochloride

Cas:79559-97-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Ality Chemical Corporation

We are manufacturer of this product. If you are looking for the material's manufacturer or supplier in China, Ality Group is your best choice. Specifications of our Sertraline hydrochloride CAS 79559-97-0: Items

Factory Supply Sertraline hydrochloride cas 79559-97-0

Cas:79559-97-0

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

CAS 79559-97-0 Sertraline hydrochloride

Cas:79559-97-0

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Sertraline Hydrochloride CAS 79559-97-0 Sertraline HCl

Cas:79559-97-0

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 79559-97-0 with best quality

Cas:79559-97-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Sertraline hydrochloride

Cas:79559-97-0

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Sertraline hydrochloride/ LIDE PHARMA- Factory supply / Best price

Cas:79559-97-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Product Name Sertraline hydrochloride Synonyms (1S,4S)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPHTHALENAMINE HYDROCHLORIDE;(1S,4S)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-N

Sertraline hydrochloride

Cas:79559-97-0

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

Sertraline Hydrochloride Manufacturer For Psychiatric Drugs

Cas:79559-97-0

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Hefei TNJ chemical industry co.,ltd

1. We are one of the domestic largest manufacturers of API; 2. We are always the supplier of products with higher quality and at more competitive price; 3. We are supplier of safe and ecofriendly products ; 4. We provide stable supply and

Manufacturer of Sertraline HCL at Factory Price

Cas:79559-97-0

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1-Naphthalenamine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, hydrochloride (1:1),(1S,4S)- 79559-97-0

Cas:79559-97-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

About us Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad.

Sertraline hydrochloride

Cas:79559-97-0

Min.Order:1 Gram

FOB Price: $7.0 / 12.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Sertraline hydrochloride CAS:79559-97-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

Sertraline hydrochloride CAS:79559-97-0

Cas:79559-97-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-Naphthalenamine,4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, hydrochloride (1:1),(1S,4S)-

Cas:79559-97-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

High Quality Raw Material Sertraline Hydrochloride

Cas:79559-97-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Sertraline HCL

Cas:79559-97-0

Min.Order:1 Kilogram

FOB Price: $120.0 / 140.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Sertraline hydrochloride

Cas:79559-97-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater

Sertraline hydrochloride

Cas:79559-97-0

Min.Order:0 Metric Ton

FOB Price: $18.0 / 20.0

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Sertraline HCl 79559-97-0

Cas:79559-97-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

sertraline 4-methoxybenzoate

sertraline 4-methoxybenzoate

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether; nitromethane at 25 - 30℃; for 1h; Product distribution / selectivity;97%
Sertraline
79617-96-2

Sertraline

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In propan-1-ol at 30℃; for 1h; Product distribution / selectivity;96%
With hydrogenchloride In acetonitrile for 1h; Product distribution / selectivity;95%
With hydrogenchloride In octanol for 1h; Product distribution / selectivity;95%
(1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine citrate
836597-67-2

(1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine citrate

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In acetonitrile at 20℃; for 1h; Product distribution / selectivity;95%
With hydrogenchloride In propan-1-ol; water at 20 - 70℃; for 1h; pH=0; Product distribution / selectivity;90%
(1S-cis)-4-(3,4 dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine mandelate

(1S-cis)-4-(3,4 dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine mandelate

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methoxypropyl acetate at 20 - 70℃; for 3h; Product distribution / selectivity;95%
With N,N-dimethylacetamide hydrochloride In 4-methyl-2-pentanone at 20 - 80℃; for 1.5h; Product distribution / selectivity;94%
With N,N-dimethylacetamide hydrochloride In acetonitrile at 20℃; for 1h; Product distribution / selectivity;90%
sertraline adipate
928057-23-2

sertraline adipate

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether; nitromethane at 25 - 30℃; for 1h; Product distribution / selectivity;86%
(cis-1S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine (R)-mandelate
244223-89-0, 79617-97-3

(cis-1S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine (R)-mandelate

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane; water Industrial scale;85%
With hydrogenchloride In acetonitrile at 0 - 15℃; for 0.5 - 1h; Product distribution / selectivity;82.6%
With hydrogenchloride In tert-Amyl alcohol at 25 - 30℃; for 8h; pH=2.0; Product distribution / selectivity;
C17H17Cl2N*C5H9NO4

C17H17Cl2N*C5H9NO4

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
Stage #1: C17H17Cl2N*C5H9NO4 With sodium hydroxide In water; toluene at 80℃; for 3h;
Stage #2: With hydrogenchloride In ethanol pH=1.0; Heating;
83.68%
sertraline phthalate
928057-20-9

sertraline phthalate

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether; 4-methyl-2-pentanone at 25 - 70℃; for 3h; Product distribution / selectivity;79%
sertraline 4-methylbenzoate
928057-24-3

sertraline 4-methylbenzoate

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether; nitromethane at 25 - 30℃; for 1h; Product distribution / selectivity;79%
sertraline salicylate
928057-22-1

sertraline salicylate

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether; nitromethane at 25 - 30℃; for 1h; Product distribution / selectivity;73%
(+/-)-N-methyl-[(cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]amine hydrochloride

(+/-)-N-methyl-[(cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]amine hydrochloride

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
Purification / work up;46%
hydrogenchloride
7647-01-0

hydrogenchloride

(1S,4S)-sertraline*(S)-mandelic acid
1357380-69-8

(1S,4S)-sertraline*(S)-mandelic acid

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
In water; isopropyl alcohol at 20℃; pH=1 - 2; Heating / reflux;
1S-cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine-mandelate
254731-40-3

1S-cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine-mandelate

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
Stage #1: 1S-cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine-mandelate With sodium hydroxide In water; ethyl acetate pH=2;
Stage #2: With hydrogenchloride In isopropyl alcohol pH=2;
sertraline acetate

sertraline acetate

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In isopropyl alcohol; toluene at 20 - 60℃; pH=1 - 2; Conversion of starting material;
With hydrogenchloride In water at 20 - 25℃; for 1h; pH=1 - 2;
With hydrogenchloride In isopropyl alcohol; toluene at 0 - 60℃; for 0.25 - 0.333333h; pH=1 - 2; Conversion of starting material;
With hydrogenchloride In isopropyl alcohol at 15 - 50℃; for 0.5h; pH=1 - 2; Conversion of starting material;
acetic acid
64-19-7

acetic acid

Sertraline
79617-96-2

Sertraline

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
Stage #1: acetic acid; Sertraline In water at 5 - 25℃; for 1.33333h;
Stage #2: With hydrogenchloride In water at 5 - 15℃; for 1.25h;
(1S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine

(1S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine

A

trans-(1S,4R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride
79896-31-4

trans-(1S,4R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride

B

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol; water Product distribution / selectivity;
With hydrogenchloride In water; ethyl acetate Product distribution / selectivity;
With hydrogenchloride In water; isopropyl alcohol Product distribution / selectivity;
N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine
79560-20-6

N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine

4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine hydrochloride

4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine hydrochloride

B

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
Stage #1: N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine With hydrogen; pyridine hydrochloride; 50% Pd/C In methanol at 25 - 35℃; for 6h;
Stage #2: With hydrogenchloride In methanol; water pH=1 - 2; Product distribution / selectivity;
Stage #1: N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine With hydrogen; pyridine hydrochloride; platinum on carbon In methanol at 25 - 35℃; for 0.5h;
Stage #2: With hydrogenchloride In methanol; water pH=1 - 2; Product distribution / selectivity;
Stage #1: N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine With hydrogen; N,N-dimethylacetamide hydrochloride; 50% Pd/C In methanol at 25 - 35℃; for 4h;
Stage #2: With hydrogenchloride In methanol; water pH=1 - 2; Product distribution / selectivity;
(S)-N-(4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene)methanamine
312620-93-2

(S)-N-(4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene)methanamine

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere
2: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere; Autoclave
2: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere
View Scheme
α-naphthol
90-15-3

α-naphthol

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: aluminum (III) chloride / 4 h / 100 °C / Inert atmosphere
2: chiral HPLC / Resolution of racemate
3: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve
4: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere
5: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: aluminum (III) chloride / 4 h / 100 °C / Inert atmosphere
2: chiral HPLC / Resolution of racemate
3: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve
4: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere; Autoclave
5: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 8 steps
1.1: aluminum (III) chloride / 1.5 h / 100 °C / Inert atmosphere
2.1: borane N,N-diethylaniline complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 6 h / 25 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
4.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere
4.2: 40 h / -40 °C / Inert atmosphere
5.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere
6.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
6.2: 0 - 20 °C / Inert atmosphere
7.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere
8.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere
View Scheme
4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one
79560-19-3

4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: chiral HPLC / Resolution of racemate
2: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve
3: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere
4: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: chiral HPLC / Resolution of racemate
2: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve
3: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere; Autoclave
4: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 7 steps
1.1: borane N,N-diethylaniline complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 6 h / 25 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
3.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere
3.2: 40 h / -40 °C / Inert atmosphere
4.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere
5.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
5.2: 0 - 20 °C / Inert atmosphere
6.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere
7.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere
View Scheme
(4S)-4-(3,4-dichlorophenyl)-1-tetralone
79560-19-3, 79836-44-5, 124379-29-9

(4S)-4-(3,4-dichlorophenyl)-1-tetralone

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve
2: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere
3: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve
2: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere; Autoclave
3: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: methanol; dichloromethane / 4 h / 20 °C / Molecular sieve; Inert atmosphere
2: C43H30BF15N2O2RuS; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Autoclave
3: hydrogenchloride / acetic acid methyl ester / 6 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: methanol; dichloromethane / 4 h / 20 °C / Molecular sieve; Inert atmosphere
2: C43H30BF15N2O2RuS; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Autoclave
3: hydrogenchloride / acetic acid methyl ester / 6 h / 20 °C
View Scheme
1,2-dichloro-benzene
95-50-1

1,2-dichloro-benzene

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: aluminum (III) chloride / 4 h / 100 °C / Inert atmosphere
2: chiral HPLC / Resolution of racemate
3: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve
4: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere
5: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: aluminum (III) chloride / 4 h / 100 °C / Inert atmosphere
2: chiral HPLC / Resolution of racemate
3: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve
4: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere; Autoclave
5: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 8 steps
1.1: aluminum (III) chloride / 1.5 h / 100 °C / Inert atmosphere
2.1: borane N,N-diethylaniline complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 6 h / 25 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
4.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere
4.2: 40 h / -40 °C / Inert atmosphere
5.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere
6.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
6.2: 0 - 20 °C / Inert atmosphere
7.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere
8.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere
View Scheme
(4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-ylidene)methylamine
261776-41-4

(4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-ylidene)methylamine

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere
2: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: [RuBArF(p-cymene)(S,S)-MsDPEN]; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere
2: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: C43H30BF15N2O2RuS; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Autoclave
2: hydrogenchloride / acetic acid methyl ester / 6 h / 20 °C
View Scheme
cis-(1S,4S)-N-(tert-butoxycarbonyl)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
267884-85-5

cis-(1S,4S)-N-(tert-butoxycarbonyl)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethyl acetate at 20℃; for 6h; Inert atmosphere; optical yield given as %ee;500 mg
With hydrogenchloride In acetic acid methyl ester at 20℃; for 6h;500 mg
(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ol
167026-37-1

(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ol

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere
2.2: 40 h / -40 °C / Inert atmosphere
3.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere
4.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
4.2: 0 - 20 °C / Inert atmosphere
5.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere
6.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere
View Scheme
(1S,4S)-1-(benzyloxy)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalene
1346228-87-2

(1S,4S)-1-(benzyloxy)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalene

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere
1.2: 40 h / -40 °C / Inert atmosphere
2.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
4.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere
5.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere
View Scheme
benzyl (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamate
1346228-88-3

benzyl (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamate

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere
3.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere
View Scheme
benzyl (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl(methyl)carbamate
1346228-89-4

benzyl (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl(methyl)carbamate

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere
2: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere
View Scheme
sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Sertraline
79617-96-2

Sertraline

Conditions
ConditionsYield
With sodium hydroxide In water; toluene for 0.25h; pH=> 10;93%
With sodium hydroxide In water; ethyl acetate77%
With ammonium hydroxide In water pH=10;
With sodium hydroxide In water
With potassium carbonate In water at 20℃;10.9 g
carbonochloridic acid, chloromethyl ester
22128-62-7

carbonochloridic acid, chloromethyl ester

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

chloromethyl ((1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)(methyl)carbamate

chloromethyl ((1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)(methyl)carbamate

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 4.5h;88%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

cis-(1S,4S)-N-(tert-butoxycarbonyl)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
267884-85-5

cis-(1S,4S)-N-(tert-butoxycarbonyl)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 2.33333h; Inert atmosphere;86%
sertraline hydrochloride
79559-97-0

sertraline hydrochloride

Cis-(1S)-N-methyl-7-chlorosulphonyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrogen sulphate

Cis-(1S)-N-methyl-7-chlorosulphonyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrogen sulphate

Conditions
ConditionsYield
With chlorosulfonic acid; trifluoroacetic acid at 20℃; for 16h;72%
1-(1,3-bis(palmitoyloxy)propan-2-yl) 10-(4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl) decanedioate

1-(1,3-bis(palmitoyloxy)propan-2-yl) 10-(4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl) decanedioate

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

1-(1,3-bis(palmitoyloxy)propan-2-yl) 10-(4-(((((1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)(methyl)carbamoyl)oxy)methyl)phenyl) decanedioate

1-(1,3-bis(palmitoyloxy)propan-2-yl) 10-(4-(((((1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)(methyl)carbamoyl)oxy)methyl)phenyl) decanedioate

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;65%
3-(2-((6-((1,3-bis(palmitoyloxy)propan-2-yl)oxy)-6-oxohexanoyl)oxy)-4,6-dimethylphenyl)-3-methylbutanoic acid

3-(2-((6-((1,3-bis(palmitoyloxy)propan-2-yl)oxy)-6-oxohexanoyl)oxy)-4,6-dimethylphenyl)-3-methylbutanoic acid

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

1,3-bis(palmitoyloxy)propan-2-yl (2-(4-(((1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)(methyl)amino)-2-methyl-4-oxobutan-2-yl)-3,5-dimethylphenyl) adipate

1,3-bis(palmitoyloxy)propan-2-yl (2-(4-(((1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)(methyl)amino)-2-methyl-4-oxobutan-2-yl)-3,5-dimethylphenyl) adipate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 16h;61%
sertraline hydrochloride
79559-97-0

sertraline hydrochloride

UK-373911

UK-373911

Conditions
ConditionsYield
Stage #1: sertraline hydrochloride With chlorosulfonic acid In dichloromethane at 20℃; for 0.5h;
Stage #2: With thionyl chloride In dichloromethane at 20℃; for 16h;
Stage #3: With ammonia; trifluoroacetic acid more than 3 stages;
58%
sertraline hydrochloride
79559-97-0

sertraline hydrochloride

(1S-cis )-4-(3,4-dichlorophenyl)-7-iodo-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine
291306-20-2

(1S-cis )-4-(3,4-dichlorophenyl)-7-iodo-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine

Conditions
ConditionsYield
Stage #1: sertraline hydrochloride With N-iodo-succinimide; trifluorormethanesulfonic acid In dichloromethane at 0℃; for 41h;
Stage #2: With sodium hydroxide In dichloromethane; water
35%
Stage #1: sertraline hydrochloride With N-iodo-succinimide; trifluorormethanesulfonic acid In dichloromethane at 0℃; for 41h;
Stage #2: With sodium hydroxide In dichloromethane; water
35%
sertraline hydrochloride
79559-97-0

sertraline hydrochloride

C17H16Cl2IN*HI

C17H16Cl2IN*HI

Conditions
ConditionsYield
With iodine In ethanol
acetic acid
64-19-7

acetic acid

sertraline hydrochloride
79559-97-0

sertraline hydrochloride

sertraline hydrochloride acetic acid solvate
620168-87-8, 820211-78-7

sertraline hydrochloride acetic acid solvate

Conditions
ConditionsYield
at 20 - 60℃; for 16h;
sertraline hydrochloride
79559-97-0

sertraline hydrochloride

A

Cis-(1S)-N-methyl-7-(nitro)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

Cis-(1S)-N-methyl-7-(nitro)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

B

C17H16Cl2N2O2

C17H16Cl2N2O2

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; potassium nitrate; trifluoroacetic acid at 0℃; for 1.5h;

Downstream Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View