Sertraline hydrochloride CAS 79559-97-0 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality
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inquiryProName: API Raw Pharmaceutical Material Sertra... CasNo: 79559-97-0 Molecular Formula: C17H18Cl3N Appearance: white powder Application: Pharmaceutical raw intermediates DeliveryTime: Within 5 days after payment PackAge:
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquirySinoway's Advantages: - ISO 9001:2008 certificated company - SGS Audited Company - 26-year experienced in pharmaceutical industry - China office of Fischer Chemicals AG (Switzerland) Appearance:A WHITE CRYSTALLINE POWDER Storage
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White or almost white powder Storage:Desiccate at RT Package:
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inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryWe are manufacturer of this product. If you are looking for the material's manufacturer or supplier in China, Ality Group is your best choice. Specifications of our Sertraline hydrochloride CAS 79559-97-0: Items
Cas:79559-97-0
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inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryProduct Name Sertraline hydrochloride Synonyms (1S,4S)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPHTHALENAMINE HYDROCHLORIDE;(1S,4S)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-N
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inquiry1. We are one of the domestic largest manufacturers of API; 2. We are always the supplier of products with higher quality and at more competitive price; 3. We are supplier of safe and ecofriendly products ; 4. We provide stable supply and
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
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Cas:79559-97-0
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
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inquirysertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; nitromethane at 25 - 30℃; for 1h; Product distribution / selectivity; | 97% |
Sertraline
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In propan-1-ol at 30℃; for 1h; Product distribution / selectivity; | 96% |
With hydrogenchloride In acetonitrile for 1h; Product distribution / selectivity; | 95% |
With hydrogenchloride In octanol for 1h; Product distribution / selectivity; | 95% |
(1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine citrate
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In acetonitrile at 20℃; for 1h; Product distribution / selectivity; | 95% |
With hydrogenchloride In propan-1-ol; water at 20 - 70℃; for 1h; pH=0; Product distribution / selectivity; | 90% |
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In methoxypropyl acetate at 20 - 70℃; for 3h; Product distribution / selectivity; | 95% |
With N,N-dimethylacetamide hydrochloride In 4-methyl-2-pentanone at 20 - 80℃; for 1.5h; Product distribution / selectivity; | 94% |
With N,N-dimethylacetamide hydrochloride In acetonitrile at 20℃; for 1h; Product distribution / selectivity; | 90% |
sertraline adipate
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; nitromethane at 25 - 30℃; for 1h; Product distribution / selectivity; | 86% |
(cis-1S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine (R)-mandelate
sertraline hydrochloride
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane; water Industrial scale; | 85% |
With hydrogenchloride In acetonitrile at 0 - 15℃; for 0.5 - 1h; Product distribution / selectivity; | 82.6% |
With hydrogenchloride In tert-Amyl alcohol at 25 - 30℃; for 8h; pH=2.0; Product distribution / selectivity; |
sertraline hydrochloride
Conditions | Yield |
---|---|
Stage #1: C17H17Cl2N*C5H9NO4 With sodium hydroxide In water; toluene at 80℃; for 3h; Stage #2: With hydrogenchloride In ethanol pH=1.0; Heating; | 83.68% |
sertraline phthalate
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; 4-methyl-2-pentanone at 25 - 70℃; for 3h; Product distribution / selectivity; | 79% |
sertraline 4-methylbenzoate
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; nitromethane at 25 - 30℃; for 1h; Product distribution / selectivity; | 79% |
sertraline salicylate
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In diethyl ether; nitromethane at 25 - 30℃; for 1h; Product distribution / selectivity; | 73% |
sertraline hydrochloride
Conditions | Yield |
---|---|
Purification / work up; | 46% |
hydrogenchloride
(1S,4S)-sertraline*(S)-mandelic acid
sertraline hydrochloride
Conditions | Yield |
---|---|
In water; isopropyl alcohol at 20℃; pH=1 - 2; Heating / reflux; |
1S-cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine-mandelate
sertraline hydrochloride
Conditions | Yield |
---|---|
Stage #1: 1S-cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine-mandelate With sodium hydroxide In water; ethyl acetate pH=2; Stage #2: With hydrogenchloride In isopropyl alcohol pH=2; |
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In isopropyl alcohol; toluene at 20 - 60℃; pH=1 - 2; Conversion of starting material; | |
With hydrogenchloride In water at 20 - 25℃; for 1h; pH=1 - 2; | |
With hydrogenchloride In isopropyl alcohol; toluene at 0 - 60℃; for 0.25 - 0.333333h; pH=1 - 2; Conversion of starting material; | |
With hydrogenchloride In isopropyl alcohol at 15 - 50℃; for 0.5h; pH=1 - 2; Conversion of starting material; |
Conditions | Yield |
---|---|
Stage #1: acetic acid; Sertraline In water at 5 - 25℃; for 1.33333h; Stage #2: With hydrogenchloride In water at 5 - 15℃; for 1.25h; |
A
trans-(1S,4R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride
B
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water Product distribution / selectivity; | |
With hydrogenchloride In water; ethyl acetate Product distribution / selectivity; | |
With hydrogenchloride In water; isopropyl alcohol Product distribution / selectivity; |
N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine
B
sertraline hydrochloride
Conditions | Yield |
---|---|
Stage #1: N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine With hydrogen; pyridine hydrochloride; 50% Pd/C In methanol at 25 - 35℃; for 6h; Stage #2: With hydrogenchloride In methanol; water pH=1 - 2; Product distribution / selectivity; | |
Stage #1: N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine With hydrogen; pyridine hydrochloride; platinum on carbon In methanol at 25 - 35℃; for 0.5h; Stage #2: With hydrogenchloride In methanol; water pH=1 - 2; Product distribution / selectivity; | |
Stage #1: N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine With hydrogen; N,N-dimethylacetamide hydrochloride; 50% Pd/C In methanol at 25 - 35℃; for 4h; Stage #2: With hydrogenchloride In methanol; water pH=1 - 2; Product distribution / selectivity; |
(S)-N-(4-(3,4-dichlorophenyl)-3,4-dihydronaphthalen-1(2H)-ylidene)methanamine
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere 2: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere; Autoclave 2: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme |
α-naphthol
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: aluminum (III) chloride / 4 h / 100 °C / Inert atmosphere 2: chiral HPLC / Resolution of racemate 3: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve 4: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere 5: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1: aluminum (III) chloride / 4 h / 100 °C / Inert atmosphere 2: chiral HPLC / Resolution of racemate 3: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve 4: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere; Autoclave 5: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 8 steps 1.1: aluminum (III) chloride / 1.5 h / 100 °C / Inert atmosphere 2.1: borane N,N-diethylaniline complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 6 h / 25 °C / Inert atmosphere 3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 3.2: 0 - 20 °C / Inert atmosphere 4.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere 4.2: 40 h / -40 °C / Inert atmosphere 5.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere 6.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 6.2: 0 - 20 °C / Inert atmosphere 7.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere 8.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere View Scheme |
4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: chiral HPLC / Resolution of racemate 2: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve 3: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere 4: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: chiral HPLC / Resolution of racemate 2: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve 3: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere; Autoclave 4: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 7 steps 1.1: borane N,N-diethylaniline complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 6 h / 25 °C / Inert atmosphere 2.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 2.2: 0 - 20 °C / Inert atmosphere 3.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere 3.2: 40 h / -40 °C / Inert atmosphere 4.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere 5.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 5.2: 0 - 20 °C / Inert atmosphere 6.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere 7.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere View Scheme |
(4S)-4-(3,4-dichlorophenyl)-1-tetralone
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve 2: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere 3: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve 2: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere; Autoclave 3: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: methanol; dichloromethane / 4 h / 20 °C / Molecular sieve; Inert atmosphere 2: C43H30BF15N2O2RuS; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Autoclave 3: hydrogenchloride / acetic acid methyl ester / 6 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: methanol; dichloromethane / 4 h / 20 °C / Molecular sieve; Inert atmosphere 2: C43H30BF15N2O2RuS; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Autoclave 3: hydrogenchloride / acetic acid methyl ester / 6 h / 20 °C View Scheme |
1,2-dichloro-benzene
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: aluminum (III) chloride / 4 h / 100 °C / Inert atmosphere 2: chiral HPLC / Resolution of racemate 3: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve 4: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere 5: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1: aluminum (III) chloride / 4 h / 100 °C / Inert atmosphere 2: chiral HPLC / Resolution of racemate 3: methanol; dichloromethane / 96 h / 20 °C / Inert atmosphere; Molecular sieve 4: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere; Autoclave 5: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 8 steps 1.1: aluminum (III) chloride / 1.5 h / 100 °C / Inert atmosphere 2.1: borane N,N-diethylaniline complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 6 h / 25 °C / Inert atmosphere 3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 3.2: 0 - 20 °C / Inert atmosphere 4.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere 4.2: 40 h / -40 °C / Inert atmosphere 5.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere 6.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 6.2: 0 - 20 °C / Inert atmosphere 7.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere 8.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere View Scheme |
(4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-ylidene)methylamine
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: RuBArF(p-cymene)(R,R)-MsDPEN; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere 2: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: [RuBArF(p-cymene)(S,S)-MsDPEN]; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Inert atmosphere 2: hydrogenchloride / ethyl acetate / 6 h / 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: C43H30BF15N2O2RuS; hydrogen / 1,2-dichloro-ethane / 10 h / 40 °C / 38002.6 Torr / Autoclave 2: hydrogenchloride / acetic acid methyl ester / 6 h / 20 °C View Scheme |
cis-(1S,4S)-N-(tert-butoxycarbonyl)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
sertraline hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethyl acetate at 20℃; for 6h; Inert atmosphere; optical yield given as %ee; | 500 mg |
With hydrogenchloride In acetic acid methyl ester at 20℃; for 6h; | 500 mg |
(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ol
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere 2.2: 40 h / -40 °C / Inert atmosphere 3.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere 4.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 4.2: 0 - 20 °C / Inert atmosphere 5.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere 6.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere View Scheme |
(1S,4S)-1-(benzyloxy)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalene
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium carbonate / hexane / 0.33 h / -40 °C / Inert atmosphere 1.2: 40 h / -40 °C / Inert atmosphere 2.1: water; sodium sulfite / hexane; ethyl acetate / 12 h / 20 °C / Inert atmosphere 3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 3.2: 0 - 20 °C / Inert atmosphere 4.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere 5.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere View Scheme |
benzyl (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamate
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere 3.1: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere View Scheme |
benzyl (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl(methyl)carbamate
sertraline hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen / methanol; dichloromethane; water / 5 h / 20 °C / Inert atmosphere 2: hydrogenchloride / diethyl ether / 20 °C / Inert atmosphere View Scheme |
sertraline hydrochloride
Sertraline
Conditions | Yield |
---|---|
With sodium hydroxide In water; toluene for 0.25h; pH=> 10; | 93% |
With sodium hydroxide In water; ethyl acetate | 77% |
With ammonium hydroxide In water pH=10; | |
With sodium hydroxide In water | |
With potassium carbonate In water at 20℃; | 10.9 g |
carbonochloridic acid, chloromethyl ester
sertraline hydrochloride
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0 - 20℃; for 4.5h; | 88% |
di-tert-butyl dicarbonate
sertraline hydrochloride
cis-(1S,4S)-N-(tert-butoxycarbonyl)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; for 2.33333h; Inert atmosphere; | 86% |
sertraline hydrochloride
Conditions | Yield |
---|---|
With chlorosulfonic acid; trifluoroacetic acid at 20℃; for 16h; | 72% |
sertraline hydrochloride
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h; | 65% |
sertraline hydrochloride
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 16h; | 61% |
sertraline hydrochloride
Conditions | Yield |
---|---|
Stage #1: sertraline hydrochloride With chlorosulfonic acid In dichloromethane at 20℃; for 0.5h; Stage #2: With thionyl chloride In dichloromethane at 20℃; for 16h; Stage #3: With ammonia; trifluoroacetic acid more than 3 stages; | 58% |
sertraline hydrochloride
(1S-cis )-4-(3,4-dichlorophenyl)-7-iodo-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine
Conditions | Yield |
---|---|
Stage #1: sertraline hydrochloride With N-iodo-succinimide; trifluorormethanesulfonic acid In dichloromethane at 0℃; for 41h; Stage #2: With sodium hydroxide In dichloromethane; water | 35% |
Stage #1: sertraline hydrochloride With N-iodo-succinimide; trifluorormethanesulfonic acid In dichloromethane at 0℃; for 41h; Stage #2: With sodium hydroxide In dichloromethane; water | 35% |
sertraline hydrochloride
Conditions | Yield |
---|---|
With iodine In ethanol |
acetic acid
sertraline hydrochloride
sertraline hydrochloride acetic acid solvate
Conditions | Yield |
---|---|
at 20 - 60℃; for 16h; |
sertraline hydrochloride
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid; potassium nitrate; trifluoroacetic acid at 0℃; for 1.5h; |
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