The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:862574-88-7
Min.Order:1
Negotiable
Type:Other
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:862574-88-7
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryProduct Name: 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid Synonyms: 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxyl;1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid;1-(2,2-Difluoro-benzo[1,3]diox
Cas:862574-88-7
Min.Order:1 Metric Ton
FOB Price: $230.0
Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:862574-88-7
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:862574-88-7
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:862574-88-7
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:862574-88-7
Min.Order:1 Kilogram
FOB Price: $289.0 / 499.0
Type:Trading Company
inquiryCAS No.: 862574-88-7 Synonyms: 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid Formula: C11H8F2O4 Exact Mass: 242.03900
Cas:862574-88-7
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:862574-88-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiry1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid CAS:862574-88-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermedia
Cas:862574-88-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:862574-88-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:862574-88-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:862574-88-7
Min.Order:1 Kilogram
FOB Price: $40.0 / 50.0
Type:Lab/Research institutions
inquiryProduct Name: 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid Synonyms: 1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacid;1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylic;1-(2,2-difluorobenzo[d][1,3
Cas:862574-88-7
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryAppearance:detailed see specifications Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common product
Cas:862574-88-7
Min.Order:100 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:862574-88-7
Min.Order:4 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:862574-88-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:862574-88-7
Min.Order:100 Gram
Negotiable
Type:Other
inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Cas:862574-88-7
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:862574-88-7
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquiry1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarboxylicacidAppearance:powder Storage:store in cool, dry place Package:according to customers' requirements Application:862574-88-7 Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by se
Cas:862574-88-7
Min.Order:1 Gram
Negotiable
Type:Other
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:862574-88-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:862574-88-7
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:862574-88-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:862574-88-7
Min.Order:1 Metric Ton
FOB Price: $1.5
Type:Trading Company
inquiryCAS No. 862574-88-7 Molecular formula C11H8F2O4 Molecular weight 242.17600 Accurate mass 242.03900 Appearance:Detailed see specifications Storage:keep sealed and keep from direct light Package:According to client's require
Cas:862574-88-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquirySAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in
Cas:862574-88-7
Min.Order:0 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
Cas:862574-88-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
Cas:862574-88-7
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
Cas:862574-88-7
Min.Order:0
Negotiable
Type:Trading Company
inquiry1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In tetrachloromethane; dichloromethane at 20℃; for 16h; Inert atmosphere; | 100% |
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide at 85℃; for 2h; | 95.2% |
With methanol; sodium hydroxide at 20℃; for 20h; | 87.3% |
1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarbonitrile
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarbonitrile With sodium hydroxide In ethanol at 100℃; for 3h; Inert atmosphere; Stage #2: With hydrogenchloride In ethanol; water pH=2; Cooling; Inert atmosphere; | 88% |
Stage #1: 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarbonitrile With sodium hydroxide In ethanol at 77 - 80℃; for 16h; Stage #2: With hydrogenchloride In ethanol; dichloromethane at 10 - 25℃; | 79% |
Stage #1: 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarbonitrile With sodium hydroxide In ethanol at 80℃; Stage #2: With hydrogenchloride In tert-butyl methyl ether | 69% |
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide In methanol at 10 - 30℃; for 2h; | 81.1% |
2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
79% | |
79% | |
79% |
2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile
1-Bromo-2-chloroethane
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In water at 75℃; for 24h; | 52% |
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
With water; citric acid In tert-butyl methyl ether | |
With citric acid In tert-butyl methyl ether |
tert-butyl methyl ether
N-cyclohexyl-cyclohexanamine
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride; NaOH; citric acid In ethanol; n-heptane | |
With hydrogenchloride; NaOH; citric acid In ethanol; n-heptane; water |
5-bromo-2,2-difluoro-2H-1,3-benzodioxole
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium phosphate; tri-tert-butyl phosphine / bis(dibenzylideneacetone)-palladium(0) / toluene; hexanes / 0.83 h / 23 °C / Inert atmosphere 1.2: 70 °C 2.1: hydrogenchloride / water; dimethyl sulfoxide / 40 - 75 °C 3.1: tetraoctyl ammonium bromide; potassium hydroxide / water / 1 h / 70 °C 4.1: sodium hydroxide; water / ethanol / 80 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine / toluene; hexane / 0.83 h / 23 °C / Inert atmosphere 1.2: 0.67 h / 70 °C 2.1: hydrogenchloride / dimethyl sulfoxide; water / 1 h / 40 - 75 °C 3.1: potassium hydroxide; tetraoctyl ammonium bromide / water / 1 h / 70 °C 4.1: sodium hydroxide; water / ethanol / 80 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium phosphate; bis(dibenzylideneacetone)-palladium(0); tributylphosphine / toluene; hexane / 0.85 h / 23 °C / Inert atmosphere 1.2: 70 °C 2.1: hydrogenchloride / dimethyl sulfoxide; water / 40 - 75 °C 3.1: potassium hydroxide; tetraoctyl ammonium bromide / water / 1 h / 70 °C 4.1: sodium hydroxide / ethanol / 80 °C View Scheme |
2,2-difluoro-1,3-benzodioxole-5-carboxylic acid
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 15 - 40 °C 1.2: 0.5 h / 40 - 50 °C 2.1: thionyl chloride / dmap / tert-butyl methyl ether / 1.5 h / 15 - 30 °C 3.1: dimethyl sulfoxide / 1 h / 30 - 40 °C 4.1: tetraoctyl ammonium bromide; potassium hydroxide / water / 1 h / 70 °C 5.1: sodium hydroxide; water / ethanol / 80 °C View Scheme | |
Multi-step reaction with 4 steps 1: aq. NaOH / toluene 2: thionyl chloride; aq. NaOH / dmap / water 3: NaCN / water; dimethyl sulfoxide View Scheme | |
Multi-step reaction with 4 steps 1: aq. NaOH / toluene 2: thionyl chloride; aq. NaOH / dmap / water 3: NaCN / water; dimethyl sulfoxide View Scheme |
(2,2-difluoro-1,3-benzodioxol-5-yl)methanol
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: thionyl chloride / dmap / tert-butyl methyl ether / 1.5 h / 15 - 30 °C 2: dimethyl sulfoxide / 1 h / 30 - 40 °C 3: tetraoctyl ammonium bromide; potassium hydroxide / water / 1 h / 70 °C 4: sodium hydroxide; water / ethanol / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1: thionyl chloride; aq. NaOH / dmap / water 2: NaCN / water; dimethyl sulfoxide View Scheme | |
Multi-step reaction with 3 steps 1: thionyl chloride; aq. NaOH / dmap / water 2: NaCN / water; dimethyl sulfoxide View Scheme |
5-chloromethyl-2,2-difluoro-benzo[1,3]dioxole
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: dimethyl sulfoxide / 1 h / 30 - 40 °C 2: tetraoctyl ammonium bromide; potassium hydroxide / water / 1 h / 70 °C 3: sodium hydroxide; water / ethanol / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1: dimethyl sulfoxide / 1 h / 30 - 40 °C 2: potassium hydroxide; tetraoctyl ammonium bromide / water / 1 h / 70 °C 3: sodium hydroxide; water / ethanol / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1: dimethyl sulfoxide / 1 h / 30 - 40 °C 2: potassium hydroxide; tetraoctyl ammonium bromide / water / 1 h / 70 °C 3: sodium hydroxide / ethanol / 80 °C View Scheme |
(2,2-difluoro-1,3-benzodioxol-5-yl)-1-ethyIacetate acetonitrile
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride / water; dimethyl sulfoxide / 40 - 75 °C 2: tetraoctyl ammonium bromide; potassium hydroxide / water / 1 h / 70 °C 3: sodium hydroxide; water / ethanol / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / dimethyl sulfoxide; water / 40 - 75 °C 2: potassium hydroxide; tetraoctyl ammonium bromide / water / 1 h / 70 °C 3: sodium hydroxide / ethanol / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / dimethyl sulfoxide / 40 - 75 °C 2: potassium hydroxide; tetraoctyl ammonium bromide / water / 1 h / 70 °C 3: sodium hydroxide / ethanol / 80 °C View Scheme |
1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarbonitrile
4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride; NaOH In ethanol |
N-cyclohexyl-cyclohexanamine
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride; citric acid In ethanol; n-heptane |
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride / dimethyl sulfoxide; water / 1 h / 40 - 75 °C 2: potassium hydroxide; tetraoctyl ammonium bromide / water / 1 h / 70 °C 3: sodium hydroxide; water / ethanol / 80 °C View Scheme |
2,2-difluorobenzo[1,3]dioxole-5-carboxylic acid methyl ester
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C 2: thionyl chloride / dichloromethane / 0 - 20 °C 3: dimethyl sulfoxide / 20 °C 4: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / 70 °C 5: sodium hydroxide / water / 2.5 h / Reflux View Scheme | |
Multi-step reaction with 5 steps 1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 25 °C / Inert atmosphere 2.1: thionyl chloride / dichloromethane / 4 h / 20 °C 3.1: sodium cyanide / dimethyl sulfoxide / 2 h / 20 - 40 °C 4.1: sodium hydroxide; tetrabutylammomium bromide / water; ethanol / 48 h / 70 °C / Inert atmosphere 5.1: sodium hydroxide / ethanol / 3 h / 100 °C / Inert atmosphere 5.2: pH 2 / Cooling; Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1: sodium hydroxide; lithium aluminum hydride / tetrahydrofuran; water 2: thionyl chloride; sodium hydrogencarbonate / dichloromethane 3: NaCN / water; dimethyl sulfoxide 4: aqueous KOH 5: sodium hydroxide View Scheme |
1-(2H-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: thionyl chloride / 0 - 20 °C 2: phosphorus pentachloride / toluene / 80 °C 3: triethylamine tris(hydrogen fluoride) / 48 h / 20 °C 4: sodium hydroxide; methanol / 20 h / 20 °C View Scheme |
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: phosphorus pentachloride / toluene / 80 °C 2: triethylamine tris(hydrogen fluoride) / 48 h / 20 °C 3: sodium hydroxide; methanol / 20 h / 20 °C View Scheme |
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: boron tribromide / dichloromethane / 1 h / -20 - -10 °C / Inert atmosphere 2: potassium carbonate; tetrabutylammomium bromide / dimethyl sulfoxide / 100 °C / Autoclave 3: sodium hydroxide / 2 h / 85 °C View Scheme |
(3,4-Dimethoxyphenyl)acetic acid
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C 1.2: 1 h / 20 °C 2.1: potassium carbonate / tetrahydrofuran / 2 h / 40 °C 3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.75 h / 20 °C / Inert atmosphere 3.2: 1 h / 35 - 45 °C / Inert atmosphere 4.1: boron tribromide / dichloromethane / 1 h / -20 - -10 °C / Inert atmosphere 5.1: potassium carbonate; tetrabutylammomium bromide / dimethyl sulfoxide / 100 °C / Autoclave 6.1: sodium hydroxide / 2 h / 85 °C View Scheme |
methyl (3,4-dimethoxyphenyl)acetate
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: potassium carbonate / tetrahydrofuran / 2 h / 40 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.75 h / 20 °C / Inert atmosphere 2.2: 1 h / 35 - 45 °C / Inert atmosphere 3.1: boron tribromide / dichloromethane / 1 h / -20 - -10 °C / Inert atmosphere 4.1: potassium carbonate; tetrabutylammomium bromide / dimethyl sulfoxide / 100 °C / Autoclave 5.1: sodium hydroxide / 2 h / 85 °C View Scheme |
3,4-dimethoxybenzeneacrylic acid methyl ester
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.75 h / 20 °C / Inert atmosphere 1.2: 1 h / 35 - 45 °C / Inert atmosphere 2.1: boron tribromide / dichloromethane / 1 h / -20 - -10 °C / Inert atmosphere 3.1: potassium carbonate; tetrabutylammomium bromide / dimethyl sulfoxide / 100 °C / Autoclave 4.1: sodium hydroxide / 2 h / 85 °C View Scheme |
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: toluene-4-sulfonic acid / toluene / Reflux 2: palladium 10% on activated carbon / ethanol / 46 - 60 °C / 3750.38 - 4500.45 Torr / Inert atmosphere; Autoclave 3: phosphorus tribromide / dichloromethane / 10 - 20 °C 4: potassium carbonate / N,N-dimethyl-formamide / 100 - 120 °C 5: sodium hydroxide / methanol / 2 h / 10 - 30 °C View Scheme |
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: palladium 10% on activated carbon / ethanol / 46 - 60 °C / 3750.38 - 4500.45 Torr / Inert atmosphere; Autoclave 2: phosphorus tribromide / dichloromethane / 10 - 20 °C 3: potassium carbonate / N,N-dimethyl-formamide / 100 - 120 °C 4: sodium hydroxide / methanol / 2 h / 10 - 30 °C View Scheme |
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: phosphorus tribromide / dichloromethane / 10 - 20 °C 2: potassium carbonate / N,N-dimethyl-formamide / 100 - 120 °C 3: sodium hydroxide / methanol / 2 h / 10 - 30 °C View Scheme |
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: tetrahydrofuran / 1 h / 10 - 30 °C 2: toluene-4-sulfonic acid / toluene / Reflux 3: palladium 10% on activated carbon / ethanol / 46 - 60 °C / 3750.38 - 4500.45 Torr / Inert atmosphere; Autoclave 4: phosphorus tribromide / dichloromethane / 10 - 20 °C 5: potassium carbonate / N,N-dimethyl-formamide / 100 - 120 °C 6: sodium hydroxide / methanol / 2 h / 10 - 30 °C View Scheme |
2,2-difluoro-1,3-benzodioxole
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: aluminum (III) chloride / dichloromethane / 1 h / 0 - 10 °C 2: tetrahydrofuran / 1 h / 10 - 30 °C 3: toluene-4-sulfonic acid / toluene / Reflux 4: palladium 10% on activated carbon / ethanol / 46 - 60 °C / 3750.38 - 4500.45 Torr / Inert atmosphere; Autoclave 5: phosphorus tribromide / dichloromethane / 10 - 20 °C 6: potassium carbonate / N,N-dimethyl-formamide / 100 - 120 °C 7: sodium hydroxide / methanol / 2 h / 10 - 30 °C View Scheme |
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.17 h / Inert atmosphere 2: boron trifluoride diethyl etherate / diethyl ether / 0.17 h / Inert atmosphere 3: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / dichloromethane; tetrachloromethane / 16 h / 20 °C / Inert atmosphere View Scheme |
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane carboxylic acid chloride
Conditions | Yield |
---|---|
With thionyl chloride; N,N-dimethyl-formamide for 1h; | 100% |
With thionyl chloride In toluene at 65℃; for 3h; | 99% |
With thionyl chloride In N,N-dimethyl-formamide at 20℃; for 2h; | 83% |
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl acetamide at 100℃; Flow reactor; | 99% |
1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid
Conditions | Yield |
---|---|
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 24h; Inert atmosphere; | 99% |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View