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inquiry2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chloride CAS:865352-01-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical interm
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryChemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryzhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed produc
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inquiryHangzhou Fandachem Co.,Ltd, a China-based chemical company, specialize in exporting 2-(2,2-difluoroethoxy)-6-(trifluoromethyl)benzene-1-sulfonyl chloride,cas:865352-01-8, Please contact us by email freely. We are leading exporter in China.
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryTriumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis:
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
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inquiry1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification
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inquiry1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.
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inquirybest seller Application:API
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inquirybulk production Chemsigma International Co.,Ltd. is a chemical manufacturer, specialize in custom synthesis and organic chemical manufacturing for overseas customers, in the field of API, pharmaceutical intermediates, chemical intermediates, fine ch
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquirybest seller Application:API
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiry1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta
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inquiryGood Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiry2-(2,2-difluoroethoxy)-6-(trifluoromethyl)benzene-1-sulfonyl chloride CAS#865352-01-8 Storage:Keep container tightly closed in a dry, cool and well-ventilated place. Package:25Kg/drum, 150Kg/drum, 200kg/drum, According to request. Transportation:By
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inquiryWe are a trading company aiming at providing high-quality services to customers. Established for many years, with good reputation in the industry Storage:Sealed and preserved Application:Fine chemical intermediates, used as the main raw material for
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inquiryGood Price, high main content Application:Medical intermediate; Used in organic synthesis
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inquiry1-(2,2-difluoroethoxy)-2-(propylsulphanyl)-3-(trifluoromethyl)benzene
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
With chlorine; acetic acid In water at 45 - 55℃; | 100% |
With chlorine; acetic acid In water at 45 - 55℃; for 2h; | 98% |
With chlorine In formic acid at 35 - 40℃; Solvent; Temperature; | 95.3% |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
With chlorine; acetic acid In water at 45 - 55℃; for 2h; | 94% |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
With potassium permanganate; sulfuryl dichloride In acetonitrile at 90℃; for 1h; Concentration; Reagent/catalyst; Solvent; Temperature; | 90% |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Stage #1: 1-(2,2-difluoroethoxy)-3-(trifluoromethyl)benzene With n-butyllithium; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at -78℃; for 2h; Stage #2: With sulfuryl dichloride In tetrahydrofuran at 20℃; for 4h; Reagent/catalyst; | 82% |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
With hydrogenchloride; chlorine In water; 1,2-dichloro-ethane at 50 - 55℃; for 6h; | 80.5% |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
With hydrogenchloride; chlorine In dichloromethane; water at 30 - 40℃; for 6h; | 79.3% |
1-(2,2-difluoroethoxy)-2-(propylsulphanyl)-3-(trifluoromethyl)benzene
A
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
With chlorine In water at 50℃; Solvent; Temperature; | A 78% B 12% |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium / 1,4-dioxane / Reflux 1.2: 2 h / Reflux 2.1: chlorine; acetic acid / water View Scheme |
3-fluoro-trifluoromethylbenzene
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - -70 °C / Inert atmosphere 1.2: 1 h / -70 °C / Inert atmosphere 2.1: sodium / 1,4-dioxane / Reflux 2.2: 2 h / Reflux 3.1: chlorine; acetic acid / water View Scheme |
2-chloro-1-nitro-3-(trifluoromethyl)benzene
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C 2: tetrabutyl ammonium fluoride / dimethyl sulfoxide / 3 h / 85 °C 3: sodium hydride / N,N-dimethyl-formamide 4: sodium hydrogensulfite; formic acid / 1.5 h / 23 - 37 °C View Scheme |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tetrabutyl ammonium fluoride / dimethyl sulfoxide / 3 h / 85 °C 2: sodium hydride / N,N-dimethyl-formamide 3: sodium hydrogensulfite; formic acid / 1.5 h / 23 - 37 °C View Scheme |
2-(3-(trifluoromethyl)phenoxy)tetrahydro-2H-pyran
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: N,N,N,N,-tetramethylethylenediamine; N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -70 - 20 °C / Inert atmosphere; Large scale 1.2: 18 h / -70 - 20 °C / Large scale 2.1: hydrogenchloride / water; ethanol / 12 h / 20 °C 3.1: potassium carbonate / acetone / Reflux 4.1: acetic acid; chlorine / 2 h View Scheme | |
Multi-step reaction with 5 steps 1.1: isopropylamine; n-butyllithium / hexane; cyclohexane / 2 h / -78 °C / Inert atmosphere 1.2: 2 h / 25 °C 2.1: hydrogenchloride / isopropyl alcohol; water / 6 h / 82 °C 3.1: sodium iodide / isopropyl alcohol; water / 2 h / 150 °C 4.1: sodium carbonate / toluene / 3 h / 110 °C 5.1: sulfuryl dichloride; potassium permanganate / acetonitrile / 1 h / 90 °C View Scheme |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: hydrogenchloride / water; ethanol / 12 h / 20 °C 2: potassium carbonate / acetone / Reflux 3: acetic acid; chlorine / 2 h View Scheme |
3-Trifluoromethylphenol
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: hydrogenchloride / 1,4-dioxane / 20 °C 2.1: N,N,N,N,-tetramethylethylenediamine; N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -70 - 20 °C / Inert atmosphere; Large scale 2.2: 18 h / -70 - 20 °C / Large scale 3.1: hydrogenchloride / water; ethanol / 12 h / 20 °C 4.1: potassium carbonate / acetone / Reflux 5.1: acetic acid; chlorine / 2 h View Scheme | |
Multi-step reaction with 6 steps 1.1: toluene-4-sulfonic acid / dichloromethane / 2 h / 25 °C 2.1: isopropylamine; n-butyllithium / hexane; cyclohexane / 2 h / -78 °C / Inert atmosphere 2.2: 2 h / 25 °C 3.1: hydrogenchloride / isopropyl alcohol; water / 6 h / 82 °C 4.1: sodium iodide / isopropyl alcohol; water / 2 h / 150 °C 5.1: sodium carbonate / toluene / 3 h / 110 °C 6.1: sulfuryl dichloride; potassium permanganate / acetonitrile / 1 h / 90 °C View Scheme |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / acetone / Reflux 2: acetic acid; chlorine / 2 h View Scheme |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: hydrogenchloride / isopropyl alcohol; water / 6 h / 82 °C 2: sodium iodide / isopropyl alcohol; water / 2 h / 150 °C 3: sodium carbonate / toluene / 3 h / 110 °C 4: sulfuryl dichloride; potassium permanganate / acetonitrile / 1 h / 90 °C View Scheme |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium iodide / isopropyl alcohol; water / 2 h / 150 °C 2: sodium carbonate / toluene / 3 h / 110 °C 3: sulfuryl dichloride; potassium permanganate / acetonitrile / 1 h / 90 °C View Scheme |
1,2-dichloro-3-(trifluoromethyl)benzene
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium fluoride; tetraphenylphosphonium bromide / sulfolane / 20 h / 250 - 300 °C / Autoclave 2: potassium carbonate / N,N-dimethyl-formamide / 6 h / -5 - 50 °C 3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 24 h / 20 °C / Inert atmosphere 4: hydrogenchloride; chlorine / water; 1,2-dichloro-ethane / 6 h / 50 - 55 °C View Scheme |
1,2-difluoro-3-(trifluoromethyl)benzene
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 6 h / -5 - 50 °C 2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 24 h / 20 °C / Inert atmosphere 3: hydrogenchloride; chlorine / water; 1,2-dichloro-ethane / 6 h / 50 - 55 °C View Scheme |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 24 h / 20 °C / Inert atmosphere 2: hydrogenchloride; chlorine / water; 1,2-dichloro-ethane / 6 h / 50 - 55 °C View Scheme |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydride / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere 2: hydrogenchloride; chlorine / dichloromethane; water / 6 h / 30 - 40 °C View Scheme |
3-bromo-1-trifluoromethylbenzene
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: lithium hexamethyldisilazane / diethyl ether / 0.75 h / -78 °C 1.2: 2 h 2.1: sodium t-butanolate; copper(I) bromide / 48 h / 80 °C 3.1: formic acid; N-chloro-succinimide / water; acetonitrile / 10 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / 0.92 h / -78 °C 1.2: 2 h / -78 - 20 °C 2.1: sodium 2.2: 48 h / 100 °C 3.1: N-chloro-succinimide; hydrogenchloride / acetonitrile; water / 20 °C View Scheme |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium amide / N,N-dimethyl-formamide / 2 h / 0 - 25 °C 1.2: 12 h 2.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C View Scheme |
2-bromo-5-nitro-benzotrifluoride
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: chlorine; sulfuric acid / 60 °C 2.1: ammonium chloride; zinc / water; ethanol / 3 h / Reflux 3.1: sodium nitrite; sulfuric acid / tetrahydrofuran; water / 1 h / -5 °C 3.2: 8 h 4.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -25 °C / Inert atmosphere 4.2: Inert atmosphere 5.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 2 h / 0 - 25 °C 5.2: 12 h 6.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: N-Bromosuccinimide; sulfuric acid / 70 - 80 °C 2.1: hydrogenchloride; zinc / 5 h / 45 °C 3.1: tert.-butylnitrite / N,N-dimethyl-formamide / 2 h / Heating 4.1: isopropylmagnesium bromide / tetrahydrofuran / 2 h / -40 °C / Inert atmosphere 4.2: Inert atmosphere 5.1: sodium amide / N,N-dimethyl-formamide / 2 h / 0 - 25 °C 5.2: 12 h 6.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: N-Bromosuccinimide; sulfuric acid / 70 - 80 °C 2.1: hydrogenchloride; zinc / 5 h / 45 °C 3.1: tert.-butylnitrite / N,N-dimethyl-formamide / 2 h / Heating 4.1: magnesium; ethylene dibromide / tetrahydrofuran / 20 - 40 °C 4.2: 5 - 20 °C 5.1: sodium amide / N,N-dimethyl-formamide / 2 h / 0 - 25 °C 5.2: 12 h 6.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C View Scheme |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: ammonium chloride; zinc / water; ethanol / 3 h / Reflux 2.1: sodium nitrite; sulfuric acid / tetrahydrofuran; water / 1 h / -5 °C 2.2: 8 h 3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -25 °C / Inert atmosphere 3.2: Inert atmosphere 4.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 2 h / 0 - 25 °C 4.2: 12 h 5.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C View Scheme |
4-bromo-3-chloro-5-(trifluoromethyl)aniline
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sodium nitrite; sulfuric acid / tetrahydrofuran; water / 1 h / -5 °C 1.2: 8 h 2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -25 °C / Inert atmosphere 2.2: Inert atmosphere 3.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 2 h / 0 - 25 °C 3.2: 12 h 4.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C View Scheme |
2-bromo-1-chloro-3-(trifluoromethyl)benzene
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -25 °C / Inert atmosphere 1.2: Inert atmosphere 2.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 2 h / 0 - 25 °C 2.2: 12 h 3.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C View Scheme |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 2 h / 0 - 25 °C 1.2: 12 h 2.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C View Scheme |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: hydrogenchloride; zinc / 5 h / 45 °C 2.1: tert.-butylnitrite / N,N-dimethyl-formamide / 2 h / Heating 3.1: isopropylmagnesium bromide / tetrahydrofuran / 2 h / -40 °C / Inert atmosphere 3.2: Inert atmosphere 4.1: sodium amide / N,N-dimethyl-formamide / 2 h / 0 - 25 °C 4.2: 12 h 5.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: hydrogenchloride; zinc / 5 h / 45 °C 2.1: tert.-butylnitrite / N,N-dimethyl-formamide / 2 h / Heating 3.1: magnesium; ethylene dibromide / tetrahydrofuran / 20 - 40 °C 3.2: 5 - 20 °C 4.1: sodium amide / N,N-dimethyl-formamide / 2 h / 0 - 25 °C 4.2: 12 h 5.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C View Scheme |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: tert.-butylnitrite / N,N-dimethyl-formamide / 2 h / Heating 2.1: isopropylmagnesium bromide / tetrahydrofuran / 2 h / -40 °C / Inert atmosphere 2.2: Inert atmosphere 3.1: sodium amide / N,N-dimethyl-formamide / 2 h / 0 - 25 °C 3.2: 12 h 4.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: tert.-butylnitrite / N,N-dimethyl-formamide / 2 h / Heating 2.1: magnesium; ethylene dibromide / tetrahydrofuran / 20 - 40 °C 2.2: 5 - 20 °C 3.1: sodium amide / N,N-dimethyl-formamide / 2 h / 0 - 25 °C 3.2: 12 h 4.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C View Scheme |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
2-fluoro-N-methylaniline
Conditions | Yield |
---|---|
With 3,5-Lutidine In dimethyl sulfoxide; toluene at 60 - 65℃; for 4.5h; | 94.36% |
2-amino-5,8-dimethoxy[1,2,4]triazolo-[1,5-c]pyrimidine
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
With 3,5-Lutidine; dimethyl sulfoxide In 3,5-Lutidine at 20℃; for 8.5h; Product distribution / selectivity; | 91% |
With 3,5-Lutidine; dimethyl sulfoxide In acetonitrile at 20℃; for 24h; Product distribution / selectivity; | 89% |
With 3-Methylpyridine; N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-S,S-dimethylsulfilimine hydrochloride In acetonitrile at 8 - 48℃; for 20 - 48h; Product distribution / selectivity; | 86% |
5,7-dimethoxy-[1,2,4]-triazolo-[1,5-a]-pyrimidin-2-amine
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
With 3,5-Lutidine; dimethyl sulfoxide In acetonitrile at 35℃; for 1h; | 84.9% |
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
2-amino-5,7-dimethyl<1,2,4>triazolo<1,5-a>pyrimidine
Conditions | Yield |
---|---|
With 3,5-Lutidine; dimethyl sulfoxide In acetonitrile at 35℃; for 1h; | 83.3% |
2-amino-5,8-dimethoxy[1,2,4]triazolo-[1,5-c]pyrimidine
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
Conditions | Yield |
---|---|
With pyridine; dimethyl sulfoxide In acetonitrile Molecular sieve; | 54% |
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