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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2-(2, 2-Difluoroethoxy)-6-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride

Cas:865352-01-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Orga

2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chlorideCAS NO.865352-01-8

Cas:865352-01-8

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzenesulfonyl chloride, 2-(2,2-difluoroethoxy)-6-(trifluoromethyl)- 865352-01-8

Cas:865352-01-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chloride CAS:865352-01-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical interm

2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chloride CAS:865352-01-8

Cas:865352-01-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzenesulfonyl chloride, 2-(2,2-difluoroethoxy)-6-(trifluoromethyl)-

Cas:865352-01-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chloride

Cas:865352-01-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-(2,2-difluoroethoxy)-6-(trifluoromethyl)benzene-1-sulfonyl chloride

Cas:865352-01-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chloride

Cas:865352-01-8

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed produc

High Quality 2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chloride 865352-01-8 Manufacturer

Cas:865352-01-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

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Hangzhou Fandachem Co.,Ltd

Hangzhou Fandachem Co.,Ltd, a China-based chemical company, specialize in exporting 2-(2,2-difluoroethoxy)-6-(trifluoromethyl)benzene-1-sulfonyl chloride,cas:865352-01-8, Please contact us by email freely. We are leading exporter in China.

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chloride

Cas:865352-01-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chloride

Cas:865352-01-8

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis:

2-(2,2-difluoroethoxy)-6-(trifluoromethyl)benzenesulfonyl chloride

Cas:865352-01-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Benzenesulfonyl chloride, 2-(2,2-difluoroethoxy)-6-(trifluoromethyl)-

Cas:865352-01-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chloride

Cas:865352-01-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

2-(2,2-difluoroethoxy)-6-(trifluoromethyl)benzenesulfonyl chloride

Cas:865352-01-8

Min.Order:0

Negotiable

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

Benzenesulfonyl chloride, 2-(2,2-difluoroethoxy)-6-(trifluoromethyl)-

Cas:865352-01-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chloride

Cas:865352-01-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Chemsigma International Co.,Ltd.

bulk production Chemsigma International Co.,Ltd. is a chemical manufacturer, specialize in custom synthesis and organic chemical manufacturing for overseas customers, in the field of API, pharmaceutical intermediates, chemical intermediates, fine ch

2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chloride

Cas:865352-01-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Benzenesulfonyl chloride, 2-(2,2-difluoroethoxy)-6-(trifluoromethyl)-

Cas:865352-01-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

best seller Application:API

2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chloride

Cas:865352-01-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chloride

Cas:865352-01-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chloride

Cas:865352-01-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

865352-01-8

Cas:865352-01-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hebei Muhuang Technology Co., Ltd

best seller Application:API

2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chloride

Cas:865352-01-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chloride

Cas:865352-01-8

Min.Order:0

Negotiable

Type:Trading Company

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ORCHID CHEMICAL SUPPLIES LTD

2-(2,2-difluoroethoxy)-6-(trifluoromethyl)benzene-1-sulfonyl chloride CAS#865352-01-8 Storage:Keep container tightly closed in a dry, cool and well-ventilated place. Package:25Kg/drum, 150Kg/drum, 200kg/drum, According to request. Transportation:By

2-(2,2-difluoroethoxy)-6-(trifluoromethyl)benzene-1-sulfonyl chloride

Cas:865352-01-8

Min.Order:0

Negotiable

Type:Other

inquiry

Taizhou volsen chemical Co., Ltd

We are a trading company aiming at providing high-quality services to customers. Established for many years, with good reputation in the industry Storage:Sealed and preserved Application:Fine chemical intermediates, used as the main raw material for

2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chloride

Cas:865352-01-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Skyrun Industrial Co.,Ltd

Good Price, high main content Application:Medical intermediate; Used in organic synthesis

2-(2,2-difluoroethoxy)-6-(trifluoroMethyl)benzene-1-sulfonyl chloride

Cas:865352-01-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Synthetic route

1-(2,2-difluoroethoxy)-2-(propylsulphanyl)-3-(trifluoromethyl)benzene
924647-38-1

1-(2,2-difluoroethoxy)-2-(propylsulphanyl)-3-(trifluoromethyl)benzene

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
With chlorine; acetic acid In water at 45 - 55℃;100%
With chlorine; acetic acid In water at 45 - 55℃; for 2h;98%
With chlorine In formic acid at 35 - 40℃; Solvent; Temperature;95.3%
2-(2,2-difluoroethoxy)- 6-trifluoromethylanisole

2-(2,2-difluoroethoxy)- 6-trifluoromethylanisole

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
With chlorine; acetic acid In water at 45 - 55℃; for 2h;94%
C18H12F10O2S2

C18H12F10O2S2

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
With potassium permanganate; sulfuryl dichloride In acetonitrile at 90℃; for 1h; Concentration; Reagent/catalyst; Solvent; Temperature;90%
1-(2,2-difluoroethoxy)-3-(trifluoromethyl)benzene

1-(2,2-difluoroethoxy)-3-(trifluoromethyl)benzene

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Stage #1: 1-(2,2-difluoroethoxy)-3-(trifluoromethyl)benzene With n-butyllithium; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at -78℃; for 2h;
Stage #2: With sulfuryl dichloride In tetrahydrofuran at 20℃; for 4h; Reagent/catalyst;
82%
C11H11F5OS

C11H11F5OS

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
With hydrogenchloride; chlorine In water; 1,2-dichloro-ethane at 50 - 55℃; for 6h;80.5%
C16H13F5OS

C16H13F5OS

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
With hydrogenchloride; chlorine In dichloromethane; water at 30 - 40℃; for 6h;79.3%
1-(2,2-difluoroethoxy)-2-(propylsulphanyl)-3-(trifluoromethyl)benzene
924647-38-1

1-(2,2-difluoroethoxy)-2-(propylsulphanyl)-3-(trifluoromethyl)benzene

A

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

B

propyl 2-(2,2-Difluoroethyl)-4-trifluoromethylbenzenesulfone

propyl 2-(2,2-Difluoroethyl)-4-trifluoromethylbenzenesulfone

Conditions
ConditionsYield
With chlorine In water at 50℃; Solvent; Temperature;A 78%
B 12%
2-fluoro-6-trifluoromethyl-n-propylsulfanylbenzene

2-fluoro-6-trifluoromethyl-n-propylsulfanylbenzene

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium / 1,4-dioxane / Reflux
1.2: 2 h / Reflux
2.1: chlorine; acetic acid / water
View Scheme
3-fluoro-trifluoromethylbenzene
401-80-9

3-fluoro-trifluoromethylbenzene

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - -70 °C / Inert atmosphere
1.2: 1 h / -70 °C / Inert atmosphere
2.1: sodium / 1,4-dioxane / Reflux
2.2: 2 h / Reflux
3.1: chlorine; acetic acid / water
View Scheme
2-chloro-1-nitro-3-(trifluoromethyl)benzene
39974-35-1

2-chloro-1-nitro-3-(trifluoromethyl)benzene

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C
2: tetrabutyl ammonium fluoride / dimethyl sulfoxide / 3 h / 85 °C
3: sodium hydride / N,N-dimethyl-formamide
4: sodium hydrogensulfite; formic acid / 1.5 h / 23 - 37 °C
View Scheme
1-nitro-2-propylthio-3-trifluoromethylbenzene

1-nitro-2-propylthio-3-trifluoromethylbenzene

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrabutyl ammonium fluoride / dimethyl sulfoxide / 3 h / 85 °C
2: sodium hydride / N,N-dimethyl-formamide
3: sodium hydrogensulfite; formic acid / 1.5 h / 23 - 37 °C
View Scheme
2-(3-(trifluoromethyl)phenoxy)tetrahydro-2H-pyran
896732-43-7

2-(3-(trifluoromethyl)phenoxy)tetrahydro-2H-pyran

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N,N,N,N,-tetramethylethylenediamine; N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -70 - 20 °C / Inert atmosphere; Large scale
1.2: 18 h / -70 - 20 °C / Large scale
2.1: hydrogenchloride / water; ethanol / 12 h / 20 °C
3.1: potassium carbonate / acetone / Reflux
4.1: acetic acid; chlorine / 2 h
View Scheme
Multi-step reaction with 5 steps
1.1: isopropylamine; n-butyllithium / hexane; cyclohexane / 2 h / -78 °C / Inert atmosphere
1.2: 2 h / 25 °C
2.1: hydrogenchloride / isopropyl alcohol; water / 6 h / 82 °C
3.1: sodium iodide / isopropyl alcohol; water / 2 h / 150 °C
4.1: sodium carbonate / toluene / 3 h / 110 °C
5.1: sulfuryl dichloride; potassium permanganate / acetonitrile / 1 h / 90 °C
View Scheme
2-(2-(propylthio)-3-(trifluoromethyl)phenoxy)tetrahydropyran

2-(2-(propylthio)-3-(trifluoromethyl)phenoxy)tetrahydropyran

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / water; ethanol / 12 h / 20 °C
2: potassium carbonate / acetone / Reflux
3: acetic acid; chlorine / 2 h
View Scheme
3-Trifluoromethylphenol
98-17-9

3-Trifluoromethylphenol

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogenchloride / 1,4-dioxane / 20 °C
2.1: N,N,N,N,-tetramethylethylenediamine; N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 2.5 h / -70 - 20 °C / Inert atmosphere; Large scale
2.2: 18 h / -70 - 20 °C / Large scale
3.1: hydrogenchloride / water; ethanol / 12 h / 20 °C
4.1: potassium carbonate / acetone / Reflux
5.1: acetic acid; chlorine / 2 h
View Scheme
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / dichloromethane / 2 h / 25 °C
2.1: isopropylamine; n-butyllithium / hexane; cyclohexane / 2 h / -78 °C / Inert atmosphere
2.2: 2 h / 25 °C
3.1: hydrogenchloride / isopropyl alcohol; water / 6 h / 82 °C
4.1: sodium iodide / isopropyl alcohol; water / 2 h / 150 °C
5.1: sodium carbonate / toluene / 3 h / 110 °C
6.1: sulfuryl dichloride; potassium permanganate / acetonitrile / 1 h / 90 °C
View Scheme
2-hydroxy-6-trifluoromethylphenyl propylsulfide

2-hydroxy-6-trifluoromethylphenyl propylsulfide

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / acetone / Reflux
2: acetic acid; chlorine / 2 h
View Scheme
C12H12F3O2S(1-)*Li(1+)

C12H12F3O2S(1-)*Li(1+)

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogenchloride / isopropyl alcohol; water / 6 h / 82 °C
2: sodium iodide / isopropyl alcohol; water / 2 h / 150 °C
3: sodium carbonate / toluene / 3 h / 110 °C
4: sulfuryl dichloride; potassium permanganate / acetonitrile / 1 h / 90 °C
View Scheme
C7H5F3OS

C7H5F3OS

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium iodide / isopropyl alcohol; water / 2 h / 150 °C
2: sodium carbonate / toluene / 3 h / 110 °C
3: sulfuryl dichloride; potassium permanganate / acetonitrile / 1 h / 90 °C
View Scheme
1,2-dichloro-3-(trifluoromethyl)benzene
54773-19-2

1,2-dichloro-3-(trifluoromethyl)benzene

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium fluoride; tetraphenylphosphonium bromide / sulfolane / 20 h / 250 - 300 °C / Autoclave
2: potassium carbonate / N,N-dimethyl-formamide / 6 h / -5 - 50 °C
3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 24 h / 20 °C / Inert atmosphere
4: hydrogenchloride; chlorine / water; 1,2-dichloro-ethane / 6 h / 50 - 55 °C
View Scheme
1,2-difluoro-3-(trifluoromethyl)benzene
64248-59-5

1,2-difluoro-3-(trifluoromethyl)benzene

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 6 h / -5 - 50 °C
2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 24 h / 20 °C / Inert atmosphere
3: hydrogenchloride; chlorine / water; 1,2-dichloro-ethane / 6 h / 50 - 55 °C
View Scheme
2-fluoro-6-trifluoromethyl-ethylsulfanylbenzene

2-fluoro-6-trifluoromethyl-ethylsulfanylbenzene

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 24 h / 20 °C / Inert atmosphere
2: hydrogenchloride; chlorine / water; 1,2-dichloro-ethane / 6 h / 50 - 55 °C
View Scheme
C14H10F4S

C14H10F4S

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere
2: hydrogenchloride; chlorine / dichloromethane; water / 6 h / 30 - 40 °C
View Scheme
3-bromo-1-trifluoromethylbenzene
401-78-5

3-bromo-1-trifluoromethylbenzene

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: lithium hexamethyldisilazane / diethyl ether / 0.75 h / -78 °C
1.2: 2 h
2.1: sodium t-butanolate; copper(I) bromide / 48 h / 80 °C
3.1: formic acid; N-chloro-succinimide / water; acetonitrile / 10 °C
View Scheme
Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane / 0.92 h / -78 °C
1.2: 2 h / -78 - 20 °C
2.1: sodium
2.2: 48 h / 100 °C
3.1: N-chloro-succinimide; hydrogenchloride / acetonitrile; water / 20 °C
View Scheme
1-bromo-2-(methylsulphanyl)-3-(trifluoromethyl)benzene

1-bromo-2-(methylsulphanyl)-3-(trifluoromethyl)benzene

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium amide / N,N-dimethyl-formamide / 2 h / 0 - 25 °C
1.2: 12 h
2.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C
View Scheme
2-bromo-5-nitro-benzotrifluoride
367-67-9

2-bromo-5-nitro-benzotrifluoride

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: chlorine; sulfuric acid / 60 °C
2.1: ammonium chloride; zinc / water; ethanol / 3 h / Reflux
3.1: sodium nitrite; sulfuric acid / tetrahydrofuran; water / 1 h / -5 °C
3.2: 8 h
4.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -25 °C / Inert atmosphere
4.2: Inert atmosphere
5.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 2 h / 0 - 25 °C
5.2: 12 h
6.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C
View Scheme
Multi-step reaction with 6 steps
1.1: N-Bromosuccinimide; sulfuric acid / 70 - 80 °C
2.1: hydrogenchloride; zinc / 5 h / 45 °C
3.1: tert.-butylnitrite / N,N-dimethyl-formamide / 2 h / Heating
4.1: isopropylmagnesium bromide / tetrahydrofuran / 2 h / -40 °C / Inert atmosphere
4.2: Inert atmosphere
5.1: sodium amide / N,N-dimethyl-formamide / 2 h / 0 - 25 °C
5.2: 12 h
6.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C
View Scheme
Multi-step reaction with 6 steps
1.1: N-Bromosuccinimide; sulfuric acid / 70 - 80 °C
2.1: hydrogenchloride; zinc / 5 h / 45 °C
3.1: tert.-butylnitrite / N,N-dimethyl-formamide / 2 h / Heating
4.1: magnesium; ethylene dibromide / tetrahydrofuran / 20 - 40 °C
4.2: 5 - 20 °C
5.1: sodium amide / N,N-dimethyl-formamide / 2 h / 0 - 25 °C
5.2: 12 h
6.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C
View Scheme
2-bromo-3-trifluoromethyl-5-nitrochlorobenzene

2-bromo-3-trifluoromethyl-5-nitrochlorobenzene

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: ammonium chloride; zinc / water; ethanol / 3 h / Reflux
2.1: sodium nitrite; sulfuric acid / tetrahydrofuran; water / 1 h / -5 °C
2.2: 8 h
3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -25 °C / Inert atmosphere
3.2: Inert atmosphere
4.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 2 h / 0 - 25 °C
4.2: 12 h
5.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C
View Scheme
4-bromo-3-chloro-5-(trifluoromethyl)aniline
914225-58-4

4-bromo-3-chloro-5-(trifluoromethyl)aniline

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium nitrite; sulfuric acid / tetrahydrofuran; water / 1 h / -5 °C
1.2: 8 h
2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -25 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 2 h / 0 - 25 °C
3.2: 12 h
4.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C
View Scheme
2-bromo-1-chloro-3-(trifluoromethyl)benzene
384-16-7

2-bromo-1-chloro-3-(trifluoromethyl)benzene

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -25 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 2 h / 0 - 25 °C
2.2: 12 h
3.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C
View Scheme
1-chloro-2-(methylsulphanyl)-3-(trifluoromethyl)benzene

1-chloro-2-(methylsulphanyl)-3-(trifluoromethyl)benzene

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 2 h / 0 - 25 °C
1.2: 12 h
2.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C
View Scheme
2-bromo-3-trifluoromethyl-5-nitrobromobenzene

2-bromo-3-trifluoromethyl-5-nitrobromobenzene

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogenchloride; zinc / 5 h / 45 °C
2.1: tert.-butylnitrite / N,N-dimethyl-formamide / 2 h / Heating
3.1: isopropylmagnesium bromide / tetrahydrofuran / 2 h / -40 °C / Inert atmosphere
3.2: Inert atmosphere
4.1: sodium amide / N,N-dimethyl-formamide / 2 h / 0 - 25 °C
4.2: 12 h
5.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C
View Scheme
Multi-step reaction with 5 steps
1.1: hydrogenchloride; zinc / 5 h / 45 °C
2.1: tert.-butylnitrite / N,N-dimethyl-formamide / 2 h / Heating
3.1: magnesium; ethylene dibromide / tetrahydrofuran / 20 - 40 °C
3.2: 5 - 20 °C
4.1: sodium amide / N,N-dimethyl-formamide / 2 h / 0 - 25 °C
4.2: 12 h
5.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C
View Scheme
3,4-dibromo-5-trifluoromethylaniline

3,4-dibromo-5-trifluoromethylaniline

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: tert.-butylnitrite / N,N-dimethyl-formamide / 2 h / Heating
2.1: isopropylmagnesium bromide / tetrahydrofuran / 2 h / -40 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: sodium amide / N,N-dimethyl-formamide / 2 h / 0 - 25 °C
3.2: 12 h
4.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C
View Scheme
Multi-step reaction with 4 steps
1.1: tert.-butylnitrite / N,N-dimethyl-formamide / 2 h / Heating
2.1: magnesium; ethylene dibromide / tetrahydrofuran / 20 - 40 °C
2.2: 5 - 20 °C
3.1: sodium amide / N,N-dimethyl-formamide / 2 h / 0 - 25 °C
3.2: 12 h
4.1: acetic acid; chlorine / water / 2 h / 45 - 55 °C
View Scheme
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

2-fluoro-N-methylaniline
1978-38-7

2-fluoro-N-methylaniline

2-(2,2-difluoroethoxy)-N-(2-fluorophenyl)-N-methyl-6-(trifluoromethyl)benzenesulfonamide

2-(2,2-difluoroethoxy)-N-(2-fluorophenyl)-N-methyl-6-(trifluoromethyl)benzenesulfonamide

Conditions
ConditionsYield
With 3,5-Lutidine In dimethyl sulfoxide; toluene at 60 - 65℃; for 4.5h;94.36%
2-amino-5,8-dimethoxy[1,2,4]triazolo-[1,5-c]pyrimidine
219715-62-5

2-amino-5,8-dimethoxy[1,2,4]triazolo-[1,5-c]pyrimidine

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

penoxsulam

penoxsulam

Conditions
ConditionsYield
With 3,5-Lutidine; dimethyl sulfoxide In 3,5-Lutidine at 20℃; for 8.5h; Product distribution / selectivity;91%
With 3,5-Lutidine; dimethyl sulfoxide In acetonitrile at 20℃; for 24h; Product distribution / selectivity;89%
With 3-Methylpyridine; N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-S,S-dimethylsulfilimine hydrochloride In acetonitrile at 8 - 48℃; for 20 - 48h; Product distribution / selectivity;86%
5,7-dimethoxy-[1,2,4]-triazolo-[1,5-a]-pyrimidin-2-amine
13223-43-3

5,7-dimethoxy-[1,2,4]-triazolo-[1,5-a]-pyrimidin-2-amine

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

2-(2,2-difluoroethoxy)-N-(5,7-dimethoxy[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide

2-(2,2-difluoroethoxy)-N-(5,7-dimethoxy[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide

Conditions
ConditionsYield
With 3,5-Lutidine; dimethyl sulfoxide In acetonitrile at 35℃; for 1h;84.9%
2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

2-amino-5,7-dimethyl<1,2,4>triazolo<1,5-a>pyrimidine
7135-02-6

2-amino-5,7-dimethyl<1,2,4>triazolo<1,5-a>pyrimidine

2-(2,2-difluoroethoxy)-N-(5,7-dimethyl[1,2,4]triazolo-[1,5-a]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide

2-(2,2-difluoroethoxy)-N-(5,7-dimethyl[1,2,4]triazolo-[1,5-a]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide

Conditions
ConditionsYield
With 3,5-Lutidine; dimethyl sulfoxide In acetonitrile at 35℃; for 1h;83.3%
2-amino-5,8-dimethoxy[1,2,4]triazolo-[1,5-c]pyrimidine
219715-62-5

2-amino-5,8-dimethoxy[1,2,4]triazolo-[1,5-c]pyrimidine

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride
865352-01-8

2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride

3-(2,2-difluoroethoxy)-N-(5,8-dimethoxy [1,2,4] triazolo[1,5-c]pyrimidin-2-yl)-cL,cL,cL-trifluorotoluene-2-sulfonamide

3-(2,2-difluoroethoxy)-N-(5,8-dimethoxy [1,2,4] triazolo[1,5-c]pyrimidin-2-yl)-cL,cL,cL-trifluorotoluene-2-sulfonamide

Conditions
ConditionsYield
With pyridine; dimethyl sulfoxide In acetonitrile Molecular sieve;54%

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