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inquiryAs a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences,
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inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
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inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryProduct Name: (S)-(4,5-diMethoxy-1,2-dihydrocyclobutabenzen-1-yl)-N-MethylMethanaMine Synonyms: (S)-(4,5-diMethoxy-1,2-dihydrocyclobutabenzen-1-yl)-N-MethylMethanaMine;(S)-1-(3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-MethylMethanaMine;
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
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inquiryUses:(S)-N-((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N-methylacetamide is a derivative of (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane (D461760, HCl); an intermediate in the synthesis of Ivabradine (I940500, HCl) whi
Cas:866783-12-2
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
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inquiryProduct name: (1S)-4,5-Dimethoxy-1-(Methylaminomethyl)-Benzocyclobutane CAS No.:866783-12-2 Molecule Formula:C12H17NO2 Molecule Weight:207.26 Purity: 98% Package: 25kg/drum Description:White to off-white powder Manufacture Standards:Enterprise
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inquiry(S)-(4,5-diMethoxy-1,2-dihydrocyclobutabenzen-1-yl)-N-MethylMethanaMine Chemical Properties storage temp. Sealed in dry,2-8°C
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryProductName:1-[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]-N-methylmethanamine Synonyms:(S)-(4,5-diMethoxy-1,2-dihydrocyclobutabenzen-1-yl)-N-MethylMethanaMine;(S)-1-(3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-MethylMethChemic
Cas:866783-12-2
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, in
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
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inquiryWe are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp
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inquiryLower price, higher purity,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthesis of various pesticides, medicines, s
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inquirywith high qualityAppearance:white powder Storage:Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Package:25kg/drum Application:as intermediates Transportation:by courier, air or sea Port:At any port from China
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inquiryOur clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS
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inquiryJ&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals
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inquirybest seller Application:API
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiryWe are a trading company aiming at providing high-quality services to customers. Established for many years, with good reputation in the industry Storage:Sealed and preserved Application:Fine chemical intermediates, used as the main raw material for
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inquiry[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol; dichloromethane; water at 20℃; for 1h; pH=10 - 11; | 99% |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
With sodium hydroxide In dichloromethane; water at 20℃; for 1h; pH=10 - 11; | 96% |
ethyl {[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}carbamate
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
Stage #1: ethyl {[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}carbamate With lithium aluminium tetrahydride In tetrahydrofuran at 20℃; for 1h; Heating / reflux; Stage #2: With sodium hydroxide; water In tetrahydrofuran at 15℃; | 93% |
(7S)-3,4-dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
Stage #1: (7S)-3,4-dimethoxy-N-methylbicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide With sodium tetrahydroborate; iodine In tetrahydrofuran for 24h; Reflux; Stage #2: With hydrogenchloride; water pH=3; | 90% |
With lithium aluminium tetrahydride In tetrahydrofuran for 0.5h; Reflux; | 46% |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
With sodium hydroxide In water; ethyl acetate at 25℃; for 0.166667h; | n/a |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
With sodium hydroxide In water |
3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium hydroxide / ethanol / 5 h / Reflux 2.1: (R)-1-phenyl-ethyl-amine / isopropyl alcohol / 1 h / Reflux; Resolution of racemate 3.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 20 °C 4.1: iodine; sodium tetrahydroborate / tetrahydrofuran / 24 h / Reflux 4.2: pH 3 View Scheme | |
Multi-step reaction with 5 steps 1.1: borane-THF / tetrahydrofuran / 12 h / 20 °C 1.2: 1 h 2.1: triethylamine / dichloromethane / 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / Reflux 4.1: ethanol / Resolution of racemate 5.1: sodium hydroxide / ethyl acetate View Scheme | |
Multi-step reaction with 3 steps 1.1: nitrilase of Rhodococcus erythropolis NCIMB11215 / aq. phosphate buffer; dimethyl sulfoxide / 96 h / 30 °C / pH 7.3 / Enzymatic reaction 2.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 20 °C 2.2: 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Reflux View Scheme |
(R,S)-4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carboxylic acid
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: (R)-1-phenyl-ethyl-amine / isopropyl alcohol / 1 h / Reflux; Resolution of racemate 2.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 20 °C 3.1: iodine; sodium tetrahydroborate / tetrahydrofuran / 24 h / Reflux 3.2: pH 3 View Scheme |
1-bromo-2-(bromomethyl)-4,5-dimethoxybenzene
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.25 h / -60 °C 1.2: 1 h 2.1: sodium amide / 2 h / 20 °C 3.1: borane-THF / tetrahydrofuran / 12 h / 20 °C 3.2: 1 h 4.1: triethylamine / dichloromethane / 20 °C 5.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / Reflux 6.1: ethanol / Resolution of racemate 7.1: sodium hydroxide / ethyl acetate View Scheme |
3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: sodium amide / 2 h / 20 °C 2.1: borane-THF / tetrahydrofuran / 12 h / 20 °C 2.2: 1 h 3.1: triethylamine / dichloromethane / 20 °C 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / Reflux 5.1: ethanol / Resolution of racemate 6.1: sodium hydroxide / ethyl acetate View Scheme |
1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / Reflux 3: ethanol / Resolution of racemate 4: sodium hydroxide / ethyl acetate View Scheme |
ethyl ((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)carbamate
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / Reflux 2: ethanol / Resolution of racemate 3: sodium hydroxide / ethyl acetate View Scheme |
({3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl)(methyl)amine
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ethanol / Resolution of racemate 2: sodium hydroxide / ethyl acetate View Scheme | |
Multi-step reaction with 2 steps 1: ethanol / 1 h / Reflux 2: sodium hydroxide / ethanol; water; dichloromethane / 1 h / 20 °C / pH 10 - 11 View Scheme | |
Multi-step reaction with 2 steps 1: ethanol; Isopropyl acetate / 1 h / Reflux 2: sodium hydroxide / water; dichloromethane / 1 h / 20 °C / pH 10 - 11 View Scheme |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine d-camphorsulfonate
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
With sodium hydroxide In ethyl acetate |
3,4-dimethoxy-benzaldehyde
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1.1: sodium tetrahydroborate; methanol / 0.33 h / 0 °C 2.1: acetic acid / 0.5 h / 0 °C 2.2: 0 - 20 °C 3.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.25 h / -60 °C 3.2: 1 h 4.1: sodium amide / 2 h / 20 °C 5.1: borane-THF / tetrahydrofuran / 12 h / 20 °C 5.2: 1 h 6.1: triethylamine / dichloromethane / 20 °C 7.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / Reflux 8.1: ethanol / Resolution of racemate 9.1: sodium hydroxide / ethyl acetate View Scheme |
(3,4-dimethoxyphenyl)methanol
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: acetic acid / 0.5 h / 0 °C 1.2: 0 - 20 °C 2.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.25 h / -60 °C 2.2: 1 h 3.1: sodium amide / 2 h / 20 °C 4.1: borane-THF / tetrahydrofuran / 12 h / 20 °C 4.2: 1 h 5.1: triethylamine / dichloromethane / 20 °C 6.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / Reflux 7.1: ethanol / Resolution of racemate 8.1: sodium hydroxide / ethyl acetate View Scheme |
(R)-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / isopropyl alcohol / 2 h / 65 °C 2.1: nitrilase of Rhodococcus erythropolis NCIMB11215 / aq. phosphate buffer; dimethyl sulfoxide / 96 h / 30 °C / pH 7.3 / Enzymatic reaction 3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 20 °C 3.2: 20 °C 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / isopropyl alcohol / 2 h / 65 °C 2.1: nitrilase of Rhodococcus rhodochrous NCIMB11216 / aq. phosphate buffer; dimethyl sulfoxide / 96 h / 30 °C / pH 7.3 / Enzymatic reaction 3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 20 °C 3.2: 20 °C 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / isopropyl alcohol / 2 h / 65 °C 2.1: over-expressed nitrilase of Rhodococcus rhodochrous NCIMB 11216 / aq. phosphate buffer; dimethyl sulfoxide / 6 h / 30 °C / pH 7 / Enzymatic reaction 3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 20 °C 3.2: 20 °C 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Reflux View Scheme |
(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 20 °C 1.2: 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Reflux View Scheme |
(±)-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methylamine
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.25 h / 20 °C 1.2: 12 h / 20 °C 2.1: boron trifluoride-tetrahydrofuran complex / tetrahydrofuran / 8 h / 0 - 20 °C 3.1: ethanol / 1 h / Reflux 4.1: sodium hydroxide / ethanol; water; dichloromethane / 1 h / 20 °C / pH 10 - 11 View Scheme | |
Multi-step reaction with 4 steps 1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.25 h / 20 °C 1.2: 12 h / 20 °C 2.1: boron trifluoride-tetrahydrofuran complex / tetrahydrofuran / 8 h / 0 - 20 °C 3.1: ethanol; Isopropyl acetate / 1 h / Reflux 4.1: sodium hydroxide / water; dichloromethane / 1 h / 20 °C / pH 10 - 11 View Scheme |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: boron trifluoride-tetrahydrofuran complex / tetrahydrofuran / 8 h / 0 - 20 °C 2: ethanol / 1 h / Reflux 3: sodium hydroxide / ethanol; water; dichloromethane / 1 h / 20 °C / pH 10 - 11 View Scheme | |
Multi-step reaction with 3 steps 1: boron trifluoride-tetrahydrofuran complex / tetrahydrofuran / 8 h / 0 - 20 °C 2: ethanol; Isopropyl acetate / 1 h / Reflux 3: sodium hydroxide / water; dichloromethane / 1 h / 20 °C / pH 10 - 11 View Scheme |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water at 0 - 5℃; for 10h; pH=3 - 4; Inert atmosphere; Large scale; | 1.17 kg |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
ivabradine
Conditions | Yield |
---|---|
With sodium carbonate In N,N-dimethyl-formamide at 85 - 88℃; for 8h; | 99.1% |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
2-(3-bromopropyl)isoindole-1,3-dione
2-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-1H-isoindole-1,3(2H)-dione
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 24h; Reflux; | 97% |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
1-[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N-methylmethanamine hydrochloride
Conditions | Yield |
---|---|
Stage #1: [{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine With acetic acid In ethanol at 20℃; for 0.5h; Stage #2: With hydrogenchloride at 15 - 20℃; for 1h; | 95% |
With hydrogenchloride In ethanol; ethyl acetate at 15 - 20℃; for 1h; Industry scale; | 92% |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
7,8-dimethoxy-3-[3-iodopropane]-1,3-dihydro-2H-3-benzazepin-2-one
3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 25 - 45℃; for 12h; | 91% |
Stage #1: [{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine With potassium carbonate In N,N-dimethyl-formamide at 25 - 30℃; for 0.583333h; Stage #2: 7,8-dimethoxy-3-[3-iodopropane]-1,3-dihydro-2H-3-benzazepin-2-one In N,N-dimethyl-formamide at 40 - 45℃; for 12h; | 70% |
In acetone for 18h; Reflux; | 67% |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 40 - 45℃; for 12h; Inert atmosphere; | 85% |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)propanal
ivabradine
Conditions | Yield |
---|---|
Stage #1: [{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine; 3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)propanal In ethanol at 85℃; for 1h; Autoclave; Inert atmosphere; Stage #2: With trimethylamine-N-oxide; C34H51FeNO6SSi2; hydrogen In ethanol at 85℃; under 3750.38 Torr; for 16h; Reagent/catalyst; Autoclave; Inert atmosphere; | 79% |
Stage #1: [{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine; 3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)propanal With triethylamine at 20℃; for 1h; Inert atmosphere; Stage #2: With formic acid at 85℃; for 18h; | 62% |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
1,3-chlorobromopropane
(S)-3-chloro-N-((3,4-dimethoxybicyclo[4.2,0]octa-1(6),2,4-trien-7-yl)methyl)-N-methylpropan-1-amine
Conditions | Yield |
---|---|
With potassium carbonate at 20℃; Product distribution / selectivity; | 56% |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
(S)-3-{(E)-4-[(3,4-dimethoxy-bicyclo[4.2.0]octa-1(6),2,4-trien-7-ylmethyl)methylamino]buten-2-yl}-7,8-dimethoxy-2-oxo-1,3-dihydro-benzo[d]azepin-2-one
Conditions | Yield |
---|---|
With triethylamine In acetonitrile at 20℃; for 48h; Inert atmosphere; | 40% |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
2-bromoethanol
2-[{[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]ethanol
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile Heating / reflux; |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
cyanomethyl bromide
[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]acetonitrile
Conditions | Yield |
---|---|
With sodium carbonate In 4-methyl-2-pentanone Heating / reflux; |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
4-(7,8-dimethoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-yl)-4-oxobutanal
N-{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-4-(7,8-dimethoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-N-methyl-4-oxobutan-1-amine
Conditions | Yield |
---|---|
Stage #1: [{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine; 4-(7,8-dimethoxy-1,2,4,5-tetrahydro-3H-3-benzazepin-yl)-4-oxobutanal With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 4h; Stage #2: With sodium hydroxide; water In dichloromethane |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
(1S)-10-camphorsulfonic acid
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine d-camphorsulfonate
Conditions | Yield |
---|---|
In isopropyl alcohol at 20℃; for 14h; Inert atmosphere; Reflux; |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
Acetyl-D,L-glutaminsaeure
Conditions | Yield |
---|---|
In ethanol at 20 - 80℃; for 16h; Inert atmosphere; |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
ivabradine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / 20 °C 2.1: potassium tert-butylate / dimethyl sulfoxide / 1 h / 20 °C 2.2: 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium carbonate / 20 °C 2.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C 2.2: 20 °C 3.1: hydrogen; acetic acid / 20% palladium hydroxide-activated charcoal / ethanol / 5 h / 20 °C / 3750.38 Torr View Scheme | |
Multi-step reaction with 2 steps 1.1: acetic acid / ethanol / 0.5 h / 20 °C 1.2: 1 h / 15 - 20 °C 2.1: triethylamine / acetonitrile / 12 h / 20 °C View Scheme |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
ivabradine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / 20 °C 2.1: potassium tert-butylate / dimethyl sulfoxide / 1 h / 20 °C 2.2: 20 °C 3.1: hydrogenchloride / diethyl ether; acetonitrile View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate / 20 °C 2.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C 2.2: 20 °C 3.1: hydrogen; acetic acid / 20% palladium hydroxide-activated charcoal / ethanol / 5 h / 20 °C / 3750.38 Torr 4.1: hydrogenchloride / diethyl ether; acetonitrile View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate; potassium iodide / 48 h / 85 - 90 °C 2: hydrogenchloride / acetonitrile / 20 - 25 °C 3: 5%-palladium/activated carbon; hydrogen / methanol / 18 h / 30 - 35 °C / 3000.3 - 3750.38 Torr / Autoclave View Scheme | |
Multi-step reaction with 3 steps 1.1: acetic acid / ethanol / 0.5 h / 20 °C 1.2: 1 h / 15 - 20 °C 2.1: triethylamine / acetonitrile / 12 h / 20 °C 3.1: hydrogenchloride; pyrographite / acetonitrile / 0.17 h / 70 °C / pH 2 - 3 View Scheme |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / 20 °C 2.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C 2.2: 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: potassium carbonate / acetone / 24 h / Reflux 2.1: hydrazine hydrate / ethanol / 4 h / Reflux 3.1: hydrogen / palladium 10% on activated carbon / ethanol; water / 12 h / 20 °C / 760.05 Torr 4.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C 5.1: hydrogenchloride; water; acetic acid / 1 h / 25 °C 5.2: pH 9 / Cooling with ice View Scheme |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
N-{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-N-methylpropane-1,3-diamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / acetone / 24 h / Reflux 2: hydrazine hydrate / ethanol / 4 h / Reflux View Scheme |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
N-{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-N'-(2,2-dimethoxyethyl)-N-methylpropane-1,3-diamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / acetone / 24 h / Reflux 2: hydrazine hydrate / ethanol / 4 h / Reflux 3: hydrogen / palladium 10% on activated carbon / ethanol; water / 12 h / 20 °C / 760.05 Torr View Scheme |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
N-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-(methyl)amino]propyl}-N-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl)acetamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium carbonate / acetone / 24 h / Reflux 2: hydrazine hydrate / ethanol / 4 h / Reflux 3: hydrogen / palladium 10% on activated carbon / ethanol; water / 12 h / 20 °C / 760.05 Torr 4: triethylamine / dichloromethane / 3 h / 0 - 20 °C View Scheme |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
3-(3-chloropropyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one
ivabradine hydrochloride
Conditions | Yield |
---|---|
Stage #1: [{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine; 7,8-dimethoxy-3-(3-chloropropyl)-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one With potassium carbonate; sodium iodide In acetone at 20 - 65℃; Stage #2: With triethylamine; acetyl chloride In toluene Stage #3: With hydrogenchloride In water; toluene pH=2 - 3; Product distribution / selectivity; |
[{(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl}methyl](methyl)amine
7,8-dimethoxy-3-[3-iodopropane]-1,3-dihydro-2H-3-benzazepin-2-one
ivabradine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate / acetone / 18 h / Reflux 2: acetic acid; hydrogen; palladium(II) hydroxide / 24 h / 20 °C / 3675.37 Torr View Scheme |
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