1000279-69-5 Usage
Description
A-867744, also known as a positive allosteric modulator (PAM) of α7 neuronal acetylcholine receptors, is a compound that interacts with specific receptors in the nervous system. It has the potential to improve cognitive function and is being explored for its therapeutic benefits in managing cognitive deficits associated with certain neurological conditions.
Uses
Used in Pharmaceutical Industry:
A-867744 is used as a therapeutic approach for managing cognitive deficits in patients with schizophrenia and Alzheimer's disease. Its interaction with α7 neuronal acetylcholine receptors is believed to help improve cognitive function and alleviate symptoms associated with these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1000279-69-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,0,2,7 and 9 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1000279-69:
(9*1)+(8*0)+(7*0)+(6*0)+(5*2)+(4*7)+(3*9)+(2*6)+(1*9)=95
95 % 10 = 5
So 1000279-69-5 is a valid CAS Registry Number.
1000279-69-5Relevant articles and documents
Heteromeric neuronal nicotinic acetylcholine receptors with mutant B subunits acquire sensitivity to A7-selective positive allosteric modulatorss
Stokes, Clare,Garai, Sumanta,Kulkarni, Abhijit R.,Cantwell, Lucas N.,Noviello, Colleen M.,Hibbs, Ryan E.,Horenstein, Nicole A.,Abboud, Khalil A.,Thakur, Ganesh A.,Papke, Roger L.
, p. 252 - 268 (2019)
Homomeric a7 nicotinic acetylcholine receptors (nAChR) have an intrinsically low probability of opening that can be overcome by a7-selective positive allosteric modulators (PAMs), which bind at a site involving the second transmembrane domain (TM2). Mutat
PYRROLE DERIVATIVES AND THEIR METHODS OF USE
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Page/Page column 59, (2008/06/13)
The invention relates to a series of substituted pyrrole derivatives, compositions comprising the same, and methods of treating conditions and disorders using such compounds and compositions.