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1001183-94-3

1001183-94-3

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1001183-94-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1001183-94-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,1,1,8 and 3 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1001183-94:
(9*1)+(8*0)+(7*0)+(6*1)+(5*1)+(4*8)+(3*3)+(2*9)+(1*4)=83
83 % 10 = 3
So 1001183-94-3 is a valid CAS Registry Number.

1001183-94-3Relevant articles and documents

Synthesis and activity of N-cyanoguanidine-piperazine P2X7 antagonists

Betschmann, Patrick,Bettencourt, Brian,Donnelly-Roberts, Diana,Friedman, Michael,George, Jonathan,Hirst, Gavin,Josephsohn, Nathan,Konopacki, Donald,Li, Biqin,Maull, John,Morytko, Michael J.,Moore, Nigel StJohn,Namovic, Marian,Rafferty, Paul,Salmeron-Garcia, Jose-Andres,Tarcsa, Edit,Wang, Lu,Woller, Kevin

scheme or table, p. 3848 - 3851 (2009/04/10)

A novel series of cyanoguanidine-piperazine P2X7 antagonists were identified and structure-activity relationship (SAR) studies described. Compounds were assayed for activity at human and rat P2X7 receptors in addition to their ability to inhibit IL-1β release from stimulated human whole blood cultures. Compound 27 possesses potent activity (0.12 μM) in this latter assay and demonstrates moderate clearance in-vivo.

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