1012041-42-7

Basic information

• Product Name: 4-N-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)quinazoline-4,6-diamine
• Synonyms: 4-N-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)quinazoline-4,6-diamine
• CAS NO: 1012041-42-7
• Molecular Weight: 383.861
• Mol File: 1012041-42-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-N-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)quinazoline-4,6-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-N-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)quinazoline-4,6-diamine(1012041-42-7)
• EPA Substance Registry System: 4-N-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)quinazoline-4,6-diamine(1012041-42-7)

Safety Data

• Hazardous Substances Data: 1012041-42-7(Hazardous Substances Data)

Upstream product

• 619-08-9 2-chloro-4-nitrophenol 
• 6943-17-5 6-nitroquinazolone 
• 851545-79-4 3-chloro-4-(thiazol-2-ylmethoxy)aniline 
• 851545-78-3 2-((2-chloro-4-nitrophenoxy)methyl)thiazole 
• 19815-16-8 4-chloro-6-nitro-quinazoline 
• 6943-17-5 6-nitroquinazolin-4-ol 
• 616-79-5 2-amino-5-nitro-benzoic acid 
• 1630042-67-9 N-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-6-nitroquinazolin-4-amine 

Downstream Products

• 1630042-68-0 C₂₈H₂₃ClN₆O₃S 
• 1630042-69-1 C₂₈H₂₃ClN₆O₃S 
• 1630042-70-4 C₂₂H₁₉ClN₆O₂S 
• 1630042-71-5 C₂₂H₁₉ClN₆O₂S 
• 845272-21-1 Varlitinib 

Relevant articles and documents

Preparation method of medicine for treating bile duct cancer

The invention belongs to the field of medical industry, and discloses a preparation method of a medicine for treating bile duct cancer. The preparation method of the drug Varlitinib for treating bileduct cancer comprises the following steps: with 2-amino-5-nitrobenzoic acid as a starting material, carrying out cyclization and chlorination on 2-amino-5-nitrobenzoic acid and methylimidazole acetateso as to synthesize an intermediate I; with 2-chloro-5-nitrophenol as a starting material, carrying out 2-chloromethylthiazole substitution and nitro reduction to synthesize an intermediate II; with1-amino-2-propanol as a starting material, carrying out a cyclization reaction of BTC, and carrying out chlorination to synthesize an intermediate III; and carrying out C-N coupling and nitro reduction on the intermediate I and the intermediate II, and finally carrying out a C-N coupling reaction on the intermediate I and the intermediate II and an intermediate III to synthesize Varlitinib. The method is simple and convenient to synthesize, short in route, economical in raw materials, high in yield, friendly to environment and suitable for industrial production.