851545-78-3

Basic information

• Product Name: 2-((2-chloro-4-nitrophenoxy)methyl)thiazole
• Synonyms: 2-((2-chloro-4-nitrophenoxy)methyl)thiazole;Thiazole, 2-[(2-chloro-4-nitrophenoxy)Methyl]-
• CAS NO: 851545-78-3
• Molecular Formula: C₁₀H₇ClN₂O₃S
• Molecular Weight: 270.69
• Mol File: 851545-78-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 428.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.498
• PKA: 1.90±0.10(Predicted)
• CAS DataBase Reference: 2-((2-chloro-4-nitrophenoxy)methyl)thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((2-chloro-4-nitrophenoxy)methyl)thiazole(851545-78-3)
• EPA Substance Registry System: 2-((2-chloro-4-nitrophenoxy)methyl)thiazole(851545-78-3)

Safety Data

• Hazardous Substances Data: 851545-78-3(Hazardous Substances Data)

Usage

General Description

2-((2-chloro-4-nitrophenoxy)methyl)thiazole is a chemical compound with the molecular formula C11H7ClN2O3S. It is a thiazole derivative that contains a thiazole ring and a phenyl ring with a chloro and nitro substituent. 2-((2-chloro-4-nitrophenoxy)methyl)thiazole has potential applications as a pharmaceutical intermediate or as a building block in the synthesis of other chemical compounds. It may also have biological activity and could be used in the development of new drugs or agrochemicals. However, further research is needed to fully understand its properties and potential uses.

Upstream product

• 14542-12-2 (1,3-thiazol-2-yl)methanol 
• 350-30-1 3-chloro-4-fluoronitrobenzene 
• 3364-78-1 2-chloromethyl-thiazole 
• 619-08-9 2-chloro-4-nitrophenol 

Downstream Products

• 1630042-67-9 N-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-6-nitroquinazolin-4-amine 
• 1012041-42-7 4-N-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)quinazoline-4,6-diamine 
• 1630042-68-0 C₂₈H₂₃ClN₆O₃S 
• 1630042-69-1 C₂₈H₂₃ClN₆O₃S 
• 1630042-71-5 C₂₂H₁₉ClN₆O₂S 
• 1630042-70-4 C₂₂H₁₉ClN₆O₂S 
• 851545-79-4 3-chloro-4-(thiazol-2-ylmethoxy)aniline 
• 845272-21-1 Varlitinib 

Relevant articles and documents

Preparation method of medicine for treating bile duct cancer

The invention belongs to the field of medical industry, and discloses a preparation method of a medicine for treating bile duct cancer. The preparation method of the drug Varlitinib for treating bileduct cancer comprises the following steps: with 2-amino-5-nitrobenzoic acid as a starting material, carrying out cyclization and chlorination on 2-amino-5-nitrobenzoic acid and methylimidazole acetateso as to synthesize an intermediate I; with 2-chloro-5-nitrophenol as a starting material, carrying out 2-chloromethylthiazole substitution and nitro reduction to synthesize an intermediate II; with1-amino-2-propanol as a starting material, carrying out a cyclization reaction of BTC, and carrying out chlorination to synthesize an intermediate III; and carrying out C-N coupling and nitro reduction on the intermediate I and the intermediate II, and finally carrying out a C-N coupling reaction on the intermediate I and the intermediate II and an intermediate III to synthesize Varlitinib. The method is simple and convenient to synthesize, short in route, economical in raw materials, high in yield, friendly to environment and suitable for industrial production.