101255-12-3

Basic information

• Product Name: N,N-diethyl-2-benzyl-4-pentenamide
• Synonyms: N,N-diethyl-2-benzyl-4-pentenamide
• CAS NO: 101255-12-3
• Molecular Weight: 245.365
• Mol File: 101255-12-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N,N-diethyl-2-benzyl-4-pentenamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-2-benzyl-4-pentenamide(101255-12-3)
• EPA Substance Registry System: N,N-diethyl-2-benzyl-4-pentenamide(101255-12-3)

Safety Data

• Hazardous Substances Data: 101255-12-3(Hazardous Substances Data)

Upstream product

• 18859-19-3 N,N-diethyl-3-phenylpropanamide 
• 106-95-6 allyl bromide 
• 109-89-7 diethylamine 
• 645-45-4 hydrocinnamic acid chloride 
• 18146-00-4 allyloxytrimethylsilane 

Relevant articles and documents

Formation of o-Allyl- And Allenyl-Modified Amides via Intermolecular Claisen Rearrangement

We developed a new transition-metal-free intermolecular Claisen rearrangement process to introduce allyl and allenyl groups into the α position of tertiary amides. In this transformation, amides were activated by trifluoromethanesulfonic anhydride to produce the keteniminium ion intermediates that exhibit strong electrophilic activity. This atom-economical process delivers α position-modified amides under mild conditions in moderate to good yields and showcases a broad substrate compatibility.

Diastereoselective Syn-epoxidation of 2-alkyl-4-enamides to epoxyamides: Synthesis of the Merck HIV-1 protease inhibitor epoxide intermediate

Reaction of 2-alkyl-4-enamides 2, 9-15 with NIS and aqueous sodium bicarbonate results in the diastereoselective formation of the corresponding iodohydrins 3, 16-22 with essentially no iodolactone by-product. This methodology has been successfully employe