18859-19-3

Basic information

• Product Name: N,N-diethyl-3-phenylpropanamide
• Synonyms: benzenepropanamide, N,N-diethyl-
• CAS NO: 18859-19-3
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.2961
• Mol File: 18859-19-3.mol
• Article Data: 48

Chemical Properties

• Boiling Point: 326°C at 760 mmHg
• Flash Point: 142.1°C
• Density: 0.981g/cm³
• Vapor Pressure: 0.000222mmHg at 25°C
• Refractive Index: 1.511
• CAS DataBase Reference: N,N-diethyl-3-phenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethyl-3-phenylpropanamide(18859-19-3)
• EPA Substance Registry System: N,N-diethyl-3-phenylpropanamide(18859-19-3)

Safety Data

• Hazardous Substances Data: 18859-19-3(Hazardous Substances Data)

Usage

General Description

N,N-diethyl-3-phenylpropanamide, also known as DEET, is a widely used chemical compound in insect repellents. It is effective in repelling a wide range of pests, including mosquitoes, ticks, and other biting insects. DEET works by confusing the insects' sense of smell, making it difficult for them to locate and feed on human hosts. Despite some concerns about its potential toxicity and environmental impact, DEET is approved for use by regulatory agencies such as the US Environmental Protection Agency and the World Health Organization. It is considered safe for use when applied according to the product label instructions, making it a popular choice for protecting against insect-borne diseases such as malaria, dengue fever, and Zika virus.

Upstream product

• 109-89-7 diethylamine 
• 645-45-4 hydrocinnamic acid chloride 
• 27829-46-5 N,N-diethylcinnamide 
• 27829-46-5 (E)-N,N-diethyl-3-phenylacrylamide 
• 3768-61-4 N,N,N',N'-tetraethylthioamine 
• 114050-31-6 3-Phenyl-propionic acid 2-thioxo-2H-pyridin-1-yl ester 
• 6667-19-2 benzenenesulfenyl dimethylamine 
• 24398-21-8 N,N-Diethyl-p-chlorbenzolsulfenamid 
• 24398-43-4 N,N-diethyl-S-2-nitrobenzenesulfenamide 
• 92702-58-4 α-Acetoxy-β-phenyl-propionsaeure-N,N-diaethylamid 
• 501-52-0 3-Phenylpropionic acid 
• 14371-10-9 (E)-3-phenylpropenal 
• 96650-00-9 2,3-epoxy-N,N-diethyl-3-phenylpropanamide 
• 302571-77-3 2-chloro-N,N-diethyl-3-hydroxy-3-phenylpropanamide 

Downstream Products

• 20795-51-1 1-phenylpentan-3-one 
• 1083-30-3 dihydrochalcone 
• 125796-46-5 3-benzyl-6-methyl-2H-chromen-2-one 
• 20280-86-8 3-benzyl-2H-chromen-2-one 
• 125864-16-6 3-benzyl-8-methoxy-chromen-2-one 
• 125796-53-4 2-Benzyl-3H-naphtho<2,1->pyran-3-one 
• 101255-12-3 N,N-diethyl-2-benzyl-4-pentenamide 
• 2021-28-5 ethyl dihydrocinnamate 
• 180896-96-2 (4R)-2-(2-phenyl)ethyl-thiazoline-4-carboxylic acid ethyl ester 
• 2550-26-7 4-Phenyl-2-butanone 
• 103-05-9 4-phenyl-2-methyl-2-butanol 
• 104-53-0 3-phenyl-propionaldehyde 
• 2016-42-4 tetradecylamine 
• 122-97-4 3-Phenyl-1-propanol 

Relevant articles and documents

METHOD FOR PRODUCING AMIDE COMPOUND

PROBLEM TO BE SOLVED: To provide a method whereby, while using a catalyst that contains a transition metal and can be relatively easily synthesized, even with a small amount of the transition metal, an amide compound can be produce efficiently by the α-alkylation of the amide compound. SOLUTION: A method for producing an amide compound includes the step of: causing a primary alcohol compound and an amide compound to react with each other in a reaction liquid containing a transition metal nanoparticle (M-NPs) of at least one of a ruthenium nanoparticle or an iridium nanoparticle, and a base, to produce an amide compound. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Development of a triazinedione-based dehydrative condensing reagent containing 4-(dimethylamino)pyridine as an acyl transfer catalyst

A new triazinedione-based reagent, (N,N′-dialkyl)triazinedione-4-(dimethylamino)pyridine (ATD-DMAP) was developed for the operationally simple dehydrative condensation of carboxylic acids. This reagent comprises an ATD core and DMAP as the leaving group, which is liberated into the reaction system to accelerate acyl transfer reactions. Upon adding ATD-DMAP to a mixture of carboxylic acids and alcohols in the presence of an amine base, the corresponding esters were formed rapidly at room temperature. Moreover, dehydrative condensation between carboxylic acids and amines using ATD-DMAP proceeded in high yield.

Nickel-catalyzed: C-alkylation of thioamide, amides and esters by primary alcohols through a hydrogen autotransfer strategy

A simple catalyst of Ni(OAc)2 and P(t-Bu)3 enables selective C-alkylation of thioacetamides and primary acetamides with alcohols for the first time. Monoalkylation of thioamides, amides and t-butyl esters occurs in excellent yields (>95%). Mechanistic studies reveal that the reaction proceeds via a hydrogen autotransfer pathway. This journal is