101351-60-4 Usage
Description
Benzoic acid, 3,3'-azobis[6-hydroxy-, dimethyl ester is an organic compound that serves as an intermediate in the synthesis of various pharmaceuticals and chemical products. It is characterized by its azo linkage and hydroxyl groups, which contribute to its reactivity and potential applications in different industries.
Uses
Used in Pharmaceutical Industry:
Benzoic acid, 3,3'-azobis[6-hydroxy-, dimethyl ester is used as an intermediate in the synthesis of Olsalazine Sodium Salt (O586000), a dimer of Mesalazine (M258100). Mesalazine is an anti-inflammatory drug used in the treatment of inflammatory bowel disease and ulcerative colitis. Its role in the synthesis process is crucial for the development of effective medications for these conditions.
Used in Chemical Synthesis:
Benzoic acid, 3,3'-azobis[6-hydroxy-, dimethyl ester is also used as a reagent in various chemical reactions, allowing for the formation of new compounds with potential applications in different fields. Its azo and hydroxyl functional groups make it a versatile building block for the creation of novel molecules with unique properties and uses.
Check Digit Verification of cas no
The CAS Registry Mumber 101351-60-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,3,5 and 1 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 101351-60:
(8*1)+(7*0)+(6*1)+(5*3)+(4*5)+(3*1)+(2*6)+(1*0)=64
64 % 10 = 4
So 101351-60-4 is a valid CAS Registry Number.
101351-60-4Relevant articles and documents
Calcium Coordination Solids for pH-Triggered Release of Olsalazine
Levine, Dana J.,Gonzalez, Miguel I.,Legendre, Christina M.,Run?evski, Tom?e,Oktawiec, Julia,Colwell, Kristen A.,Long, Jeffrey R.
, p. 1739 - 1742 (2017)
Calcium coordination solids were synthesized and evaluated for delivery of olsalazine (H4olz), an anti-inflammatory compound used for treatment of ulcerative colitis. The materials include one-dimensional Ca(H2olz)?4 H2O chains, two-dimensional Ca(H2olz)?2 H2O sheets, and a three-dimensional metal-organic framework Ca(H2olz)?2DMF (DMF=N,N-dimethylformamide). The framework undergoes structural changes in response to solvent, forming a dense Ca(H2olz) phase when exposed to aqueous HCl. The compounds Ca(H2olz)?x H2O (x=0, 2, 4) were each pressed into pellets and exposed to simulated gastrointestinal fluids to mimic the passage of a pill from the acidic stomach to the pH-neutral intestines. All three calcium materials exhibited a delayed release of olsalazine relative to Na2(H2olz), the commercial formulation, illustrating how formulation of a drug within an extended coordination solid can serve to tune its solubility and performance.
