1015610-31-7

Basic information

• Product Name: 4-CHLORO-5-IODO-1H-PYRROLO[2,3-B]PYRIDINE
• Synonyms: 4-CHLORO-5-IODO-1H-PYRROLO[2,3-B]PYRIDINE;4-Chloro-5-iodo-7-azaindole;4-chloro-5-iodo-1H-pyrrolo[2;1H-Pyrrolo[2,3-b]pyridine, 4-chloro-5-iodo-
• CAS NO: 1015610-31-7
• Molecular Formula: C₇H₄ClIN₂
• Molecular Weight: 278.47753
• Mol File: 1015610-31-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 2.156
• Storage Temp.: 2-8°C(protect from light)
• PKA: 12.11±0.40(Predicted)
• CAS DataBase Reference: 4-CHLORO-5-IODO-1H-PYRROLO[2,3-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-5-IODO-1H-PYRROLO[2,3-B]PYRIDINE(1015610-31-7)
• EPA Substance Registry System: 4-CHLORO-5-IODO-1H-PYRROLO[2,3-B]PYRIDINE(1015610-31-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1015610-31-7(Hazardous Substances Data)

Usage

General Description

4-Chloro-5-iodo-1H-pyrrolo[2,3-b]pyridine is a chemical compound with the molecular formula C8H4ClIN2. Its molecular weight is 282.49. This chemical belongs to the class of organic compounds known as pyrrolopyridines, which are polycyclic aromatic compounds containing a pyrrolopyridine moiety, a structural arrangement of pyrrole and pyridine rings fused together. 4-Chloro-5-iodo-1H-pyrrolo[2,3-b]pyridine is relatively less common, but is used in a variety of chemical research due to its unique functional properties. It is often utilized in the manufacture of more complex chemical structures, usually as a building block or intermediate. It is important to handle this chemical with care, as it may have hazard properties in specific conditions.

InChI:InChI=1S/C7H4ClIN2/c8-6-4-1-2-10-7(4)11-3-5(6)9/h1-3H,(H,10,11)

Upstream product

• 55052-28-3 4-chloro-7-azaindole 

Downstream Products

• 1196507-56-8 1-benzenesulfonyl-4-chloro-5-iodo-1H-pyrrolo[2,3-b]pyridine 
• 1420885-83-1 N-methyl-2-[2-(6-morpholin-4-ylpyridin-3-yl)-5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-4-ylamino]benzamide 
• 1420886-01-6 N-methyl-2-[2-(6-morpholin-4-yl-pyridin-3-yl)-5-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-4-ylamino]-benzamide 
• 1420885-70-6 N-methyl-N-{3-[7-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-1H-pyrrolo-[2,3-c]pyridin-2-yl]-pyridin-2-yl}methanesulfonamide 
• 1420885-80-8 N-methyl-2-[2-(6-oxo-1,6-dihydropyridin-3-yl)-5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-4-yl-amino]benzamide 
• 1420885-82-0 N-methyl-2-[2-(4-morpholin-4-ylphenyl)-5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-4-ylamino]benzamide 
• 1420885-84-2 (3,5-difluorobenzyl)-[2-(4-morpholin-4-yl-phenyl)-5-trifluoromethyl-1H-pyrrolo[2,3-b]-pyridin-4-yl]amine 
• 1420885-85-3 2-[2-(2-methoxy-4-morpholin-4-ylphenyl)-5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-4-yl-amino]benzonitrile 
• 1196507-57-9 1-benzenesulfonyl-4-chloro-5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine 
• 1196507-58-0 4-chloro-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

Compound with pyrrolopyridine structure, preparation method and medical application

The invention discloses a compound with a pyrrolopyridine structure, a preparation method and medical application. The compound with the pyrrolopyridine structure has obvious inhibitory activity on JAK family proteins, and is an effective JAK inhibitor, so that the compound has a prospect of being developed into drugs for inhibiting JAK and further treating diseases.

BICYCLIC HETEROAROMATIC COMPOUNDS

Compounds of the formula I, in which X1, X2, X3, X4, X5, R1, R2, R3, R4, R5 and R6 have the meanings indicated in Claim 1, are kinase inhibitors and can be employed, inter alia, for the treatment of tumours.