101860-56-4

Basic information

• Product Name: (R)-4-[(R)-3-Hydroxy-4-((2R,3R,7R,10S)-2,3,10-trimethyl-1,4,6-trioxa-spiro[4.5]dec-7-yl)-butyryl]-3-(4-methoxy-benzyl)-thiazolidin-2-one
• CAS NO: 101860-56-4
• Molecular Weight: 493.621
• Mol File: 101860-56-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-4-[(R)-3-Hydroxy-4-((2R,3R,7R,10S)-2,3,10-trimethyl-1,4,6-trioxa-spiro[4.5]dec-7-yl)-butyryl]-3-(4-methoxy-benzyl)-thiazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-[(R)-3-Hydroxy-4-((2R,3R,7R,10S)-2,3,10-trimethyl-1,4,6-trioxa-spiro[4.5]dec-7-yl)-butyryl]-3-(4-methoxy-benzyl)-thiazolidin-2-one(101860-56-4)
• EPA Substance Registry System: (R)-4-[(R)-3-Hydroxy-4-((2R,3R,7R,10S)-2,3,10-trimethyl-1,4,6-trioxa-spiro[4.5]dec-7-yl)-butyryl]-3-(4-methoxy-benzyl)-thiazolidin-2-one(101860-56-4)

Safety Data

• Hazardous Substances Data: 101860-56-4(Hazardous Substances Data)

Upstream product

• 101860-54-2 (2R,3R,7R,10S)-7-Allyl-2,3,10-trimethyl-1,4,6-trioxa-spiro[4.5]decane 
• 2746-25-0 p-Methoxybenzyl bromide 
• 87086-60-0 tetrahydro-6-(2-propenyl)pyran-2(2H)-one 
• 101860-50-8 (-)-3-(4-methoxybenzyl)-2-oxo-thiazolidine-4-carboxylic acid ethyl ester 
• 139944-38-0 (-)-3-(4-methoxybenzyl)-2-oxo-thiazolidine-4-carboxylic acid 
• 219779-32-5 6-allyl-3-methyltetrahydropyran-2-one 
• 101860-55-3 ((2R,3R,7R,10S)-2,3,10-Trimethyl-1,4,6-trioxa-spiro[4.5]dec-7-yl)-acetaldehyde 
• 101860-51-9 (-)-4-acetyl-3-(4-methoxybenzyl)-thiazolidinon-2-one 
• 646994-31-2 (S)-3-(4-Methoxy-benzyl)-2-oxo-thiazolidine-4-carbonyl chloride 

Downstream Products

• 140146-99-2 (S)-4-{(2R,4S,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-6-methoxy-6-[(R)-3-(4-methoxy-benzyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-2-methyl-butyric acid (1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-propyl ester 
• 139944-50-6 (2Z,6E,8Z)-(S)-12-{(2R,4S,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-6-methoxy-6-[(R)-3-(4-methoxy-benzyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-3,10-dimethyl-dodeca-2,6,8-trienoic acid 
• 101860-61-1 (2Z,6Z)-(S)-10-{(2R,4S,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-6-methoxy-6-[(R)-3-(4-methoxy-benzyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-3,8-dimethyl-deca-2,6-dienoic acid 
• 139944-51-7 (2Z,6E,8Z)-(S)-12-{(2R,4S,6R)-4-Hydroxy-6-methoxy-6-[(R)-3-(4-methoxy-benzyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-3,10-dimethyl-dodeca-2,6,8-trienoic acid 
• 139944-52-8 O-methyl-N-(4-methoxybenzyl)latrunculin A 
• 101860-62-2 (2Z,6Z)-(S)-10-{(2R,4S,6R)-4-Hydroxy-6-methoxy-6-[(R)-3-(4-methoxy-benzyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-3,8-dimethyl-deca-2,6-dienoic acid 
• 139944-35-7 (S)-4-{(2R,4S,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-6-methoxy-6-[(R)-3-(4-methoxy-benzyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-2-methyl-butyraldehyde 
• 101915-87-1 6,7-(Z)-N-PMB-15-OMe-Latrunculin B 
• 140146-97-0 (S)-4-{(2R,4S,6R)-4-Hydroxy-6-methoxy-6-[(R)-3-(4-methoxy-benzyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-2-methyl-butyric acid (1R,2R)-2-hydroxy-1-methyl-propyl ester 
• 139944-43-7 (R)-4-[(2R,4S,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-4-hydroxy-3-methyl-butyl)-2-methoxy-tetrahydro-pyran-2-yl]-3-(4-methoxy-benzyl)-thiazolidin-2-one 
• 139944-53-9 (R)-4-[(2R,4S,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-2-methoxy-6-(3-oxo-butyl)-tetrahydro-pyran-2-yl]-3-(4-methoxy-benzyl)-thiazolidin-2-one 
• 76343-94-7 latrunculin B 
• 76343-93-6 latrunculin A 
• 140146-98-1 (S)-4-{(2R,4R,6R)-4,6-Dihydroxy-6-[(R)-3-(4-methoxy-benzyl)-2-oxo-thiazolidin-4-yl]-tetrahydro-pyran-2-yl}-2-methyl-butyric acid (1R,2R)-2-hydroxy-1-methyl-propyl ester 

Relevant articles and documents

Total synthesis of the latrunculins

The total syntheses of (+)-latrunculin A (1) and (+)-latrunculin B (2), two architecturally novel toxins isolated from the Red Sea sponge Latrunculia magnifica (Keller), have been achieved via highly convergent and stereocontrolled routes (longest linear sequences, 16 and 12 steps, respectively). Formal syntheses of scalemic latrunculins C (3) and M (5) also derive from the construction of 2. Central features of the unified synthetic strategy include the aldol reaction of aldehyde (-)-12 with methyl ketone (-)-13, a novel acid-catalyzed reorganization-equilibration of ortho ester (-)-11, and Mitsunobu macrolide cyclization.