139944-38-0

Basic information

• Product Name: 4-Thiazolidinecarboxylic acid, 3-[(4-methoxyphenyl)methyl]-2-oxo-, (R)-
• CAS NO: 139944-38-0
• Molecular Formula: C12H13NO4S
• Molecular Weight: 267.306
• Mol File: 139944-38-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4-Thiazolidinecarboxylic acid, 3-[(4-methoxyphenyl)methyl]-2-oxo-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thiazolidinecarboxylic acid, 3-[(4-methoxyphenyl)methyl]-2-oxo-, (R)-(139944-38-0)
• EPA Substance Registry System: 4-Thiazolidinecarboxylic acid, 3-[(4-methoxyphenyl)methyl]-2-oxo-, (R)-(139944-38-0)

Safety Data

• Hazardous Substances Data: 139944-38-0(Hazardous Substances Data)

Upstream product

• 101860-50-8 (-)-3-(4-methoxybenzyl)-2-oxo-thiazolidine-4-carboxylic acid ethyl ester 
• 2746-25-0 p-Methoxybenzyl bromide 
• 824-94-2 p-methoxybenzyl chloride 
• 530-62-1 1,1'-carbonyldiimidazole 
• 65776-11-6 (R)-3-mercapto-2-(4-methoxy-benzylamino)-propionic acid 

Downstream Products

• 101860-51-9 (-)-4-acetyl-3-(4-methoxybenzyl)-thiazolidinon-2-one 
• 646994-31-2 (S)-3-(4-Methoxy-benzyl)-2-oxo-thiazolidine-4-carbonyl chloride 
• 861821-49-0 (2Z,6E)-3-Methyl-deca-2,6-dien-8-ynoic acid (2R,4R,6R)-2-methoxy-2-[(R)-3-(4-methoxy-benzyl)-2-oxo-thiazolidin-4-yl]-6-((S)-3-methyl-hex-4-ynyl)-tetrahydro-pyran-4-yl ester 
• 928112-42-9 4-[2,4-dihydroxy-6-(3-methyl-hex-4-ynyl)-tetrahydro-pyran-2-yl]-3-(4-methoxy-benzyl)-thiazolidin-2-one 
• 646994-48-1 4-[2,4-dihydroxy-6-(3-methyl-hex-4-ynyl)-tetrahydro-pyran-2-yl]-3-(4-methoxy-benzyl)-thiazolidin-2-one 
• 101915-87-1 6,7-(Z)-N-PMB-15-OMe-Latrunculin B 
• 646994-49-2 (R)-4-[(2R,4S,6R)-4-Hydroxy-2-methoxy-6-((S)-3-methyl-hex-4-ynyl)-tetrahydro-pyran-2-yl]-3-(4-methoxy-benzyl)-thiazolidin-2-one 
• 646994-46-9 (R)-4-[(5R,8S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-8-methyl-undec-9-ynoyl]-3-(4-methoxy-benzyl)-thiazolidin-2-one 
• 1053714-70-7 Trifluoro-methanesulfonic acid (2R,4S,6R)-2-methoxy-2-[(R)-3-(4-methoxy-benzyl)-2-oxo-thiazolidin-4-yl]-6-((S)-3-methyl-hex-4-ynyl)-tetrahydro-pyran-4-yl ester 
• 646994-51-6 (R)-3-(4-Methoxy-benzyl)-4-((Z)-(1R,10S,13R,15R)-15-methoxy-5,10-dimethyl-3-oxo-2,14-dioxa-bicyclo[11.3.1]heptadec-4-en-8-yn-15-yl)-thiazolidin-2-one 
• 928112-44-1 (Z)-3-Methyl-oct-2-en-6-ynoic acid (2R,4R,6R)-2-methoxy-2-[(R)-3-(4-methoxy-benzyl)-2-oxo-thiazolidin-4-yl]-6-((S)-3-methyl-hex-4-ynyl)-tetrahydro-pyran-4-yl ester 
• 101860-56-4 (R)-4-[3-Hydroxy-4-((2R,3R,7R,10S)-2,3,10-trimethyl-1,4,6-trioxa-spiro[4.5]dec-7-yl)-butyryl]-3-(4-methoxy-benzyl)-thiazolidin-2-one 
• 101860-56-4 (R)-4-[(S)-3-Hydroxy-4-((2R,3R,7R,10S)-2,3,10-trimethyl-1,4,6-trioxa-spiro[4.5]dec-7-yl)-butyryl]-3-(4-methoxy-benzyl)-thiazolidin-2-one 
• 101860-56-4 (R)-4-[(R)-3-Hydroxy-4-((2R,3R,7R,10S)-2,3,10-trimethyl-1,4,6-trioxa-spiro[4.5]dec-7-yl)-butyryl]-3-(4-methoxy-benzyl)-thiazolidin-2-one 

Relevant articles and documents

Structure-Activity Studies of Truncated Latrunculin Analogues with Antimalarial Activity

Malarial parasites employ actin dynamics for motility, and any disruption to these dynamics renders the parasites unable to effectively establish infection. Therefore, actin presents a potential target for malarial drug discovery, and naturally occurring actin inhibitors such as latrunculins are a promising starting point. However, the limited availability of the natural product and the laborious route for synthesis of latrunculins have hindered their potential development as drug candidates. In this regard, we recently described novel truncated latrunculins, with superior actin binding potency and selectivity towards P. falciparum actin than the canonical latrunculin B. In this paper, we further explore the truncated latrunculin core to summarize the SAR for inhibition of malaria motility. This study helps further understand the binding pattern of these analogues in order to develop them as drug candidates for malaria.

PROCESS FOR THE PREPARATION OF 3,4-DISUBSTITUTED-THIAZOLIDIN-2-ONES

The present invention is directed to practical high-yielding synthetic processes for preparing 3,4-disubstituted-thiazolidin-2-ones, which do not compromise the absolute stereochemical integrity of the compounds. The present invention is also directed to

Catalysis-Based Total Synthesis of Latrunculin B

The highly selective actin-binding latrunculins (e.g. 1) play a prominent role as probe molecules in chemical biology. A highly concise, productive, and inherently flexible approach to 1 illustrates the excellent profile and use of metal-catalyzed C-C bond formations.