101906-05-2

Basic information

• Product Name: 4-(TRIFLUOROMETHYL)PHENYLGLYOXAL HYDRATE
• Synonyms: 4-(TRIFLUOROMETHYL)PHENYLGLYOXAL HYDRATE;4-TRIFLUOROMETHYLPHENYLGLYOXAL HYDRATE, 95+%;2-Oxo-2-(4-(trifluoromethyl)phenyl)acetaldehyde hydrate;2-Oxo-2-(4-(trifluoromethyl)
• CAS NO: 101906-05-2
• Molecular Formula: C₉H₇F₃O₃
• Molecular Weight: 220.15
• EINECS: 604-604-1
• Mol File: 101906-05-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 223.3 °C at 760 mmHg
• Flash Point: 84.1 °C
• Appearance: /
• Density: 1.331 g/cm³
• Vapor Pressure: 0.0971mmHg at 25°C
• Refractive Index: 1.458
• CAS DataBase Reference: 4-(TRIFLUOROMETHYL)PHENYLGLYOXAL HYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIFLUOROMETHYL)PHENYLGLYOXAL HYDRATE(101906-05-2)
• EPA Substance Registry System: 4-(TRIFLUOROMETHYL)PHENYLGLYOXAL HYDRATE(101906-05-2)

Safety Data

• Hazardous Substances Data: 101906-05-2(Hazardous Substances Data)

Usage

General Description

4-(Trifluoromethyl)phenylglyoxal hydrate is a chemical compound with the molecular formula C9H9F3O3. It is a white crystalline powder that is soluble in water and organic solvents. 4-(TRIFLUOROMETHYL)PHENYLGLYOXAL HYDRATE is commonly used in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential use in organic light-emitting diodes (OLEDs) and as a fluorescent probe. 4-(Trifluoromethyl)phenylglyoxal hydrate is known to be a reactive compound with versatile reactivity, making it an important building block in organic chemistry.

InChI:InChI=1/C9H5F3O2/c10-9(11,12)7-3-1-6(2-4-7)8(14)5-13/h1-5H

Upstream product

• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 

Downstream Products

• 1153714-83-0 ethyl (2R,3S)-1-(4-methoxyphenyl)-3-(4-(trifluoromethyl)benzoyl)aziridine-2-carboxylate 
• 1217903-49-5 1,6-dimethyl-3-(4-(trifluoromethyl)phenyl)pyrimido[4,5-c]pyridazine-5,7(1H,6H)-dione 
• 1217903-56-4 C₁₅H₁₁F₃N₄O₂ 
• 1262406-39-2 2-(isopropylimino)-1-[4'-(trifluoromethyl)phenyl]ethanone 
• 1262406-36-9 2-(tert-butylimino)-1-[4'-(trifluoromethyl)phenyl]ethanone 
• 1361384-65-7 (S)-tert-butyl α-hydroxy-α-(4-(trifluoromethyl)phenyl)acetate 
• 31197-66-7 isopropyl benzoylformate 
• 53439-96-6 (S)-α-hydroxyphenylacetic acid iso-propyl ester 
• 89015-27-0 (R)-α-hydroxyphenylacetic acid iso-propyl ester 

Relevant articles and documents

Nucleophilic addition of (difluoromethyl)trimethylsilane to selected α-imino ketones and aryl diketones

Abstract Chemoselective addition of (difluoromethyl)trimethylsilane (CHF2SiMe3) to the carbonyl bond of aryl glyoxal derived α-imino ketones, and selected diaryl 1,2-diketones were studied in the presence of initiators, such as potas

Regioselective N-1 and C-2 diacylation of 3-substituted indoles with arylglyoxal hydrates for the synthesis of indolyl diketones

A highly regioselective N-1 and C-2 diacylation of 3-substituted indoles with arylglyoxal hydrates to afford N-1 and C-2 indolyl diketones in moderate to good yields is described. Notably, the control of regioselectivity is achieved by small changes in the Cu catalyst, additive and solvent. Importantly, the intermediates for N-1 and C-2 diacylation were detected and two plausible pathways were also proposed.

Naphthol synthesis: Annulation of nitrones with alkynes: Via rhodium(III)-catalyzed C-H activation

An efficient and redox-neutral naphthol synthesis has been realized via rhodium(iii) catalyzed C-H activation of α-carbonyl nitrones and annulation with alkynes, where the nitrone group functioned as a traceless directing group.