31197-66-7

Basic information

• Product Name: ISOPROPYLPHENYLGLYOXYLATE
• Synonyms: OXOPHENYL ACETIC ACID ISOPROPYL ESTER;ISOPROPYLPHENYLGLYOXYLATE
• CAS NO: 31197-66-7
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.21
• Mol File: 31197-66-7.mol
• Article Data: 46

Chemical Properties

• Boiling Point: 153.5-154.4 °C(Press: 12 Torr)
• Appearance: /
• Density: 1.102±0.06 g/cm3(Predicted)
• CAS DataBase Reference: ISOPROPYLPHENYLGLYOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ISOPROPYLPHENYLGLYOXYLATE(31197-66-7)
• EPA Substance Registry System: ISOPROPYLPHENYLGLYOXYLATE(31197-66-7)

Safety Data

• Hazardous Substances Data: 31197-66-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 52, p. 5733, 1987 DOI: 10.1021/jo00235a017

Upstream product

• 611-73-4 Benzoylformic acid 
• 67-63-0 isopropyl alcohol 
• 6831-82-9 potassium isopropoxide 
• 91851-05-7 2-<(4-chlorophenyl)amino>-2-methoxy-1-phenylethanone 
• 25726-04-9 phenylglyoxylyl chloride 
• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 
• 1074-12-0 phenylglyoxal hydrate 
• 2902-69-4 2,2,2-trichloroacetophenone 
• 7402-45-1 α,α,α-tribromoacetophenone 
• 4861-85-2 isopropyl phenylacetate 
• 108-86-1 bromobenzene 
• 264882-04-4 2-diazo-2-phenylacetic acid isopropyl ester 
• 683-60-3 sodium isopropylate 

Downstream Products

• 89015-27-0 (R)-α-hydroxyphenylacetic acid iso-propyl ester 
• 53439-96-6 (S)-α-hydroxyphenylacetic acid iso-propyl ester 
• 100-52-7 benzaldehyde 
• 67-64-1 acetone 
• 25779-13-9 (S)-1-phenyl-1,2-ethanediol 
• 1070237-09-0 isopropyl 2-hydroxy-3-nitro-2-phenylpropanoate 

Relevant articles and documents

Photoinduced Diverse Reactivity of Diazo Compounds with Nitrosoarenes

A diverse reactivity of diazo compounds with nitrosoarene in an oxygen-transfer process and a formal [2 + 2] cycloaddition is reported. Nitosoarene has been exploited as a mild oxygen source to oxidize an in situ generated carbene intermediate under visible-light irradiation. UV-light-mediated in situ generated ketenes react with nitosoarenes to deliver oxazetidine derivatives. These operationally simple processes exemplify a transition-metal-free and catalyst-free protocol to give structurally diverse α-ketoesters or oxazetidines.

Copper on charcoal: Cu0nanoparticle catalysed aerobic oxidation of α-diazo esters

By using a charcoal supported nano Cu0catalyst (Cu/C), a highly efficient oxidation of α-diazo esters to α-ketoesters with molecular oxygen as the sole oxidant has been developed. In the presence of the Cu/C catalyst, 2-aryl-α-diazo esters with both electron-donating and electron-withdrawing groups can be oxidized to the corresponding α-ketoesters efficiently. Furthermore, this Cu/C catalyst can catalyse the reaction of aryl α-diazo ester with water to form aryl ketoester, 2-aryl-2-hydroxyl acetate ester and 2-aryl acetate ester. In this case, water is split by α-diazo ester, and the diazo group is displaced by the oxygen or hydrogen atom in water. Mechanistic investigation showed that the reaction of α-diazo ester with oxygen proceeds through a radical pathway. In the presence of 2,2,6,6-tetramethyl piperidine nitrogen oxide, the reaction of α-diazo ester with oxygen is dramatically inhibited. Furthermore, the reaction of α-diazo ester with water is investigated by an isotopic tracer method, and GCMS detection showed that a disproportionation reaction occurred between α-diazo ester and water.

Cobalt-Catalyzed Transfer Hydrogenation of α-Ketoesters and N-Cyclicsulfonylimides Using H2O as Hydrogen Source

A Co-catalyzed effective transfer hydrogenation of various α-ketoesters and N-cyclicsulfonylimides by safe and environmentally benign H2O as hydrogen source is described. The reaction used easily available and easy to handle zinc metal as a reductant. Interestingly, the catalytic system does not require ligand for reduction of N-cyclicsulfonylimides. (Figure presented.).