6831-82-9Relevant articles and documents
Manganese-Mediated C-C Bond Formation: Alkoxycarbonylation of Organoboranes
Van Putten, Robbert,Filonenko, Georgy A.,Krieger, Annika M.,Lutz, Martin,Pidko, Evgeny A.
supporting information, p. 674 - 681 (2021/04/02)
Alkoxycarbonylations are important and versatile reactions that result in the formation of a new C-C bond. Herein, we report on a new and halide-free alkoxycarbonylation reaction that does not require the application of an external carbon monoxide atmosphere. Instead, manganese carbonyl complexes and organo(alkoxy)borate salts react to form an ester product containing the target C-C bond. The required organo(alkoxy)borate salts are conveniently generated from the stoichiometric reaction of an organoborane and an alkoxide salt and can be telescoped without purification. The protocol leads to the formation of both aromatic and aliphatic esters and gives complete control over the ester's substitution (e.g., OMe, OtBu, OPh). A reaction mechanism was proposed on the basis of stoichiometric reactivity studies, spectroscopy, and DFT calculations. The new chemistry is particularly relevant for the field of Mn(I) catalysis and clearly points to a potential pathway toward irreversible catalyst deactivation.
Preparation method of intermediate for synthesizing 3 -oxo -1 -cyclobutane carboxylic acid
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Paragraph 0031-0034; 0036-0039, (2021/09/29)
The invention discloses a preparation method for synthesizing 3 -oxo -1 -cyclobutane carboxylic acid intermediate 1, 1 - bis (prop -2 -) 3, 3 -dimethoxycyclobutane -1 and 1 - dicarboxylic acid ester (compound I): using potassium isopropoxide as a base, 1 1 -1 as a solvent, and plays an important role in the yield and purity method of 3 the 3 - final product, DMAc which is prepared 1 - or -2 - I
STABLE BEADLETS OF LIPOPHILIC NUTRIENTS
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Page/Page column 15, (2008/06/13)
The invention disclosed in this application relates to novel stable beadlets of lipophilic nutrients comprising an inert core having a coating comprising stabilizing antioxidant and lipophilic nutrient. The beadlets may be coated with one or more coatings to protect the lipophilic ingredients from the atmosphere, specifically the coatings can be used to protect against moisture and/or oxygen. The invention also relates to a process for the preparation of the stable beadlets. The beadlets can be used in medicines and dietary supplements intended to facilitate the reduced risk of macular degeneration, cataract, and several forms of cancer.