1026496-60-5

Basic information

• Product Name: N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-pyridin-2-yl-acetamide
• CAS NO: 1026496-60-5
• Molecular Weight: 357.39
• Mol File: 1026496-60-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-pyridin-2-yl-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-pyridin-2-yl-acetamide(1026496-60-5)
• EPA Substance Registry System: N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-pyridin-2-yl-acetamide(1026496-60-5)

Safety Data

• Hazardous Substances Data: 1026496-60-5(Hazardous Substances Data)

Upstream product

• 13115-43-0 2-pyridineacetic acid 
• 118383-51-0 5-(3-amino-4-hydroxybenzyl)-2,4-thiazolidinedione 
• 118383-62-3 5-(4-hydroxy-3-nitrobenzyl)-2,4-dioxothiazolidine 
• 118383-66-7 5-(4-hydroxy-3-nitrobenzyl)-2-imino-4-oxothiazolidine 
• 118383-65-6 2-bromo-3-(4-hydroxy-3-nitrophenyl)propionic acid 
• 621-44-3 3-nitro-L-tyrosine 

Relevant articles and documents

Novel benzoxazole 2,4-thiazolidinediones as potent hypoglycemic agents. Synthesis and structure-activity relationships

A new series of benzoxazole 2,4-thiazolidinediones was synthesized and evaluated for hypoglycemic activity in genetically obese and diabetic yellow KK mice. 2-Arylmethyl- and 2-(heteroarylmethyl)benzoxazole derivatives showed far more potent activity than known 2,4-thiazolidinedione derivatives such as ciglitazone, troglitazone and pioglitazone. A facile synthesis of benzoxazole 2,4-thiazolidinediones was also established using aminophenol 2,4- thiazolidinedione (11) as a key intermediate. Details of synthesis and structure-activity relationships for this series are described.