13115-43-0

Basic information

• Product Name: 2-Pyridylacetic acid
• Synonyms: 2-(2-Pyridyl)acetic acid;2-Pyridinylacetic acid;Pyridine-2-acetic acid;2-Pyridylacetic acid;Pyridin-2-yl-acetic acid
• CAS NO: 13115-43-0
• Molecular Formula: C₇H₇NO₂
• Molecular Weight: 137.14
• Mol File: 13115-43-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 276.173 °C at 760 mmHg
• Flash Point: 120.825 °C
• Appearance: /
• Density: 1.246 g/cm³
• Vapor Pressure: 0.00235mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 3.30±0.10(Predicted)
• CAS DataBase Reference: 2-Pyridylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridylacetic acid(13115-43-0)
• EPA Substance Registry System: 2-Pyridylacetic acid(13115-43-0)

Safety Data

• Hazardous Substances Data: 13115-43-0(Hazardous Substances Data)

Usage

General Description

2-Pyridylacetic acid, also known as 2-carboxypyridine, is a chemical compound with the formula C7H7NO2. It is a derivative of pyridine, and is commonly used as a precursor in the synthesis of pharmaceuticals and agrochemicals. 2-Pyridylacetic acid has been studied for its potential anti-inflammatory and anti-cancer properties, and has also been used in the synthesis of anti-HIV agents. It is a white to off-white crystalline powder that is soluble in water and other polar solvents. 2-Pyridylacetic acid has also been investigated for its potential application in the treatment of neurodegenerative diseases, due to its ability to modulate glutamate receptor activity.

InChI:InChI=1/C7H7NO2/c9-7(10)5-6-3-1-2-4-8-6/h1-4H,5H2,(H,9,10)

Upstream product

• 2739-98-2 ethyl 2-(pyridinyl-2)acetate 
• 85274-59-5 N-phenyl-2-(pyridin-2-yl)acetamide 
• 133604-84-9 3,5-dimethylphenyl 2-pyridylacetate 
• 109-04-6 2-bromo-pyridine 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 103-74-2 2-(2-Hydroxyethyl)pyridine 
• 61890-12-8 1-phenyl-2-[2]pyridyl-ethanone-(E)-oxime 
• 1620-53-7 1-phenyl-2-pyridin-2-ylethanone 
• 81334-62-5 5-isopropyl-5-methyl-2-(3-methyl-2-pyridyl)-2-imidazolin-4-one 
• 55401-97-3 2-(Bromomethyl)pyridine 

Downstream Products

• 116376-63-7 2,6-Di-tert-butyl-4-((E)-2-pyridin-2-yl-vinyl)-phenol 
• 2739-98-2 ethyl 2-(pyridinyl-2)acetate 
• 1026496-60-5 N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-pyridin-2-yl-acetamide 
• 23692-08-2 piperidin-2-yl-acetic acid methyl ester 
• 105462-23-5 1-hydroxy-2-(2-pyridinyl)ethylidene bisphosphonic acid 
• 19832-04-3 2-(piperidin-2-yl)acetic acid 
• 19615-30-6 piperidin-2-yl-acetic acid hydrochloride 
• 169384-56-9 2-methoxycarbonylmethyl-piperidine-1-carboxylic acid benzyl ester 
• 934422-94-3 2-methoxycarbonylmethyl-piperidine-1-carboxylic acid benzyl ester 
• 934422-89-6 [1-(2-nitro-benzenesulfonyl)-piperidin-2-yl]-acetic acid methyl ester 

Relevant articles and documents

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A novel decarbonylation of heterocyclic pyruvic acid derivatives using sodium perborate

Decarbonylation of imidazo-2-yl and pyrid-2-ylpyruvic acids giving the corresponding acetic acids has been achieved using aqueous sodium perborate at room temperature. It is proposed that intramolecular hydrogen bonding, which inhibits conventional decarbonylation, facilitates epoxidation and subsequent decarboxylation of the enol tautomers.

FLUORESCENT DYE AGENT AND CARBOSTYRIL COMPOUND

PROBLEM TO BE SOLVED: To provide a novel fluorescent dye agent. SOLUTION: A fluorescent dye agent contains a carbostyril compound represented by formula (1) [in the formula (1), R1 is H, a halogen atom, a hydroxyl group, a cyano group, a nitro group or the like; R2 is O; R3 is a halogen atom, a carboxyl group, an ester group, an amide group or the like; R4-R6 and R8 independently represent H, a halogen atom, a nitro group, a cyano group or the like, where mutually adjacent groups of R4-R8 may be bound to form a ring; R7 is H, a substituted or unsubstituted aliphatic group or the like]. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

Merging the structural motifs of functionalized amino acids and α-Aminoamides: Compounds with Significant Anticonvulsant Activities

Functional amino acids (FAAs) and α-aminoamides (AAAs) are two classes of antiepileptic drugs (AEDs) that exhibit pronounced anticonvulsant activities. We combined key structural pharmacophores present in FAAs and AAAs to generate a new series of compounds and document that select compounds exhibit activity superior to either the prototypical FAA (lacosamide) or the prototypical AAA (safinamide) in the maximal electroshock (MES) seizure model in rats. A representative compound, (R)-N-4′-((3′′-fluoro) benzyloxy)benzyl 2-acetamido-3-methoxypropionamide ((R)-10), was tested in the MES (mice, ip), MES (rat, po), psychomotor 6 Hz (32 mA) (mice, ip), and hippocampal kindled (rat, ip) seizure tests providing excellent protection with ED50 values of 13, 14, ～10 mg/kg, and 12 mg/kg, respectively. In the rat sciatic nerve ligation model (ip), (R)-10 (12 mg/kg) provided an 11.2-fold attenuation of mechanical allodynia. In the mouse biphasic formalin pain model (ip), (R)-10 (15 mg/kg) reduced pain responses in the acute and the chronic inflammatory phases.

Palladium-catalysed α-arylation of esters and amides under microwave conditions

A rapid and convenient approach for the α-arylation of esters and amides using Reformatsky reagents under a microwave accelerated reaction protocol has been established.