85274-59-5Relevant articles and documents
Synthesis of β-Hydroxy α-Amino Acids through Br?nsted Base-Catalyzed syn-Selective Direct Aldol Reaction of Schiff Bases of Glycine o-Nitroanilide
Vera, Silvia,Vázquez, Ana,Rodriguez, Ricardo,Pozo, Sandra Del,Urruzuno, I?aki,de Cózar, Abel,Mielgo, Antonia,Palomo, Claudio
, p. 7757 - 7772 (2021/06/21)
Here we report the highly enantio- and syn-selective synthesis of β-hydroxy α-amino acids from glycine imine derivatives under Br?nsted base (BB) catalysis. The key of this approach is the use of benzophenone-derived imine of glycine o-nitroanilide as a pronucleophile, where the o-nitroanilide framework provides an efficient hydrogen-bonding platform that accounts for nucleophile reactivity and diastereoselectivity.