1027542-25-1Relevant articles and documents
Peptidomimetic inhibitors of herpes simplex virus ribonucleotide reductase with improved in vivo antiviral activity
Moss, Neil,Beaulieu, Pierre,Duceppe, Jean-Simon,Ferland, Jean-Marie,Garneau, Michel,Gauthier, Jean,Ghiro, Elise,Goulet, Sylvie,Guse, Ingrid,Jaramillo, Jorge,Llinas-Brunet, Montse,Malenfant, éric,Plante, Raymond,Poirier, Martin,Soucy, Francois,Wernic, Dominik,Yoakim, Christiane,Déziel, Robert
, p. 4173 - 4180 (1996)
We have been investigating the potential of a new class of antiviral compounds. These peptidomimetic derivatives prevent association of the two subunits of herpes simplex virus (HSV) ribonucleotide reductase (RR), an enzyme necessary for efficient replica