103773-79-1

Basic information

• Product Name: [(2S,4S)-2-phenyl-1,3-dioxan-4-yl]methanol
• Synonyms: [(2S,4S)-2-phenyl-1,3-dioxan-4-yl]methanol
• CAS NO: 103773-79-1
• Molecular Weight: 194.23
• Mol File: 103773-79-1.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: [(2S,4S)-2-phenyl-1,3-dioxan-4-yl]methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [(2S,4S)-2-phenyl-1,3-dioxan-4-yl]methanol(103773-79-1)
• EPA Substance Registry System: [(2S,4S)-2-phenyl-1,3-dioxan-4-yl]methanol(103773-79-1)

Safety Data

• Hazardous Substances Data: 103773-79-1(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 196861-66-2 (S)-2,2,9,9-tetramethyl-5-<(trimethylsilyl)oxy>-3,8-dioxa-2,9-disiladecane 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 70005-88-8 (R)-1,2,4-butanetriol 
• 3068-00-6 D,L-1,2,4-butanetriol 
• 3969-69-5 (+/-)-cis-4-hydroxymethyl-2-phenyl-1,3-dioxolane 
• 153944-89-9 (2S,4S)-(-)-Methyl-2-phenyl-1,3-dioxan-4-carboxylat 
• 42890-76-6 (S)-1,2,4-butanetriol 
• 153944-94-6 (2S,4S)-(+)-N,N-Dimethyl-2-phenyl-1,3-dioxan-4-carboxamid 

Downstream Products

• 3969-69-5 (-)-cis-4-hydroxymethyl-2-phenyl-1,3-dioxolane 
• 130272-62-7 (2S,4S)-4-(methoxymethyl)-2-phenyl-1,3-dioxan 
• 188066-79-7 (2S,4S)-4-Ethynyl-2-phenyl-[1,3]dioxane 
• 1402820-10-3 C₁₂H₁₂O₂ 
• 1338989-37-9 C₂₉H₄₃O₉PSi 
• 1338989-64-2 C₂₉H₄₅O₉PSi 
• 1338989-63-1 C₂₆H₃₈O₆Si 
• 1338989-60-8 C₃₉H₄₆O₆Si 
• 1354973-46-8 C₃₉H₄₈O₆Si 
• 1338989-57-3 C₂₃H₃₀O₆ 

Relevant articles and documents

Preparation of (2R,4S)/(2S,4S)-4-hydroxypipecolinic acid derivatives from L-(-)-malic acid

Synthetically important 4-hydroxypipecolinic acid derivatives were efficiently prepared from commercially available L-(-)-malic acid. The stereochemistries of the derivatives synthesized by our method were determined by coupling constant analyses with key methine protons on C2 and C4.

Transacetalization of acetals with butane-1,2,4-triol using cobalt(II) chloride and chlorotrimethylsilane

Transacetalization of acetals with butane-1,2,4-triol was carried out using cobalt(II) chloride and chlorotrimethylsilane as catalysts. The reaction occurs under mild conditions in acetonitrile and with a short reaction time. The synergic effect of the two Lewis acids catalyzes the conversion of butane-1,2,4-triol into (2-alkyl- or 2-aryl-1,3-dioxan-4-yl)methanol derivatives with high regiospecificity and diasteroselectivity. Georg Thieme Verlag Stuttgart · New York.

Total Synthesis and Biological Evaluation of Siladenoserinol A and its Analogues

The total synthesis of siladenoserinol A, an inhibitor of the p53–Hdm2 interaction, has been achieved. AuCl3-catalyzed hydroalkoxylation of an alkynoate derivative smoothly and regioselectively proceeded to afford a bicycloketal in excellent yield. A glycerophosphocholine moiety was successfully introduced through the Horner–Wadsworth–Emmons reaction using an originally developed phosphonoacetate derivative. Finally, removal of the acid-labile protecting groups, followed by regioselective sulfamate formation of the serinol moiety afforded the desired siladenoserinol A, and benzoyl and desulfamated analogues were also successfully synthesized. Biological evaluation showed that the sulfamate is essential for biological activity, and modification of the acyl group on the bicycloketal can improve the inhibitory activity against the p53–Hdm2 interaction.