3068-00-6Relevant articles and documents
A new antiangiogenic C24 oxylipin from the soft coral Sinularia numerosa
Yamashita, Takahiro,Nakao, Yoichi,Matsunaga, Shigeki,Oikawa, Tsutomu,Imahara, Yukimitsu,Fusetani, Nobuhiro
, p. 2181 - 2184 (2009)
A new oxylipin, 15-hydroxy-tetracosa-6,9,12,16,18-pentaenoic acid (15-HTPE; 1) was isolated as an inhibitor of tube-formation from the soft coral Sinularia numerosa. Its structure was elucidated by means of spectral analysis and chemical degradation. 15-H
Ru/SiO2 Catalyst for Highly Selective Hydrogenation of Dimethyl Malate to 1,2,4-Butanetriol at Low Temperatures in Aqueous Solvent
Chen, Can,Jiang, Junxiang,Li, Guangci,Li, Xuebing,Wang, Da,Wang, Zhong,Yu, Pei
, (2022/01/12)
Catalytic selective hydrogenation of esterified malic acid to produce 1,2,4-butanetriol (1,2,4-BT) using H2 as the reducing reagent suffers from the low 1,2,4-BT selectivity. Here, Ru/SiO2 catalyst was employed for selective hydrogenation of dimethyl malate (DM) to produce 1,2,4-BT, which gave abnormal high DM conversion (100%) and 1,2,4-BT selectivity (92.4%) in aqueous solvent at 363?K, especially, the 1,2,4-BT yield even is higher than the optimal catalyst reported (Ru-Re, 79.8%). The reaction pathways for the DM hydrogenation on Ru/SiO2 were also proposed, suggesting that extremely high 1,2,4-BT selectivity require for the much high hydrogenation rates at low temperatures, where side-reaction transesterification rates are relatively low. The extremely high hydrogenation activity and 1,2,4-BT selectivity on Ru/SiO2 in aqueous solvent at low temperatures arise from that H2O may coordinate to Ru2+ and prevent the reduction of Ru2+ to Ru under high H2 pressure. Ru/SiO2 surface presents abundant Ru2+ in aqueous solvent, can activate H2 through heterolytic cleavage mode to form hydride, which can significantly increase hydrogenation rates of C = O groups at low temperatures. In addition, the activity and 1,2,4-BT selectivity on Ru/SiO2 catalyst only reduced by 2.3% and 2.6%, respectively over a period of 550?h. Graphical Abstract: [Figure not available: see fulltext.]
Method for preparing 1, 2, 4-butantriol through catalytic hydrogenation
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Paragraph 0016-0028, (2020/05/30)
The invention discloses a method for preparing 1, 2, 4-butantriol by catalytic hydrogenation, and the method comprises the following steps: (1) uniformly mixing dimethyl malate and n-propylamine in acertain proportion, reacting at the condensation reflux temperature of the n-propylamine, and cooling to room temperature; removing volatile components through vacuum evaporation; recrystallizing, purifying and the like to obtain corresponding malate diamide; and (2) uniformly mixing the corresponding malate diamide obtained in the step (1) and tetrahydrofuran, carrying out a hydrogenation reaction with hydrogen in the presence of a catalyst at a reaction temperature of 120-200 DEG C under an initial reaction pressure of 5-10 MPa for 10-14 h, and collecting the target product 1, 2, 4-butantriol in the reaction product. The method provided by the invention has the advantages of low cost, mild conditions, simple processing and no pollution to the environment, the reaction yield can reach 85%or above, and the method is easy for industrial implementation.