1039826-39-5

Basic information

• Product Name: (S,S)-1-(1-(2-(2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)ethyl)-1H-indazol-5-yl)-4-(benzyloxy)pyridin-2(1H)-one
• CAS NO: 1039826-39-5
• Molecular Weight: 442.517
• Mol File: 1039826-39-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S,S)-1-(1-(2-(2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)ethyl)-1H-indazol-5-yl)-4-(benzyloxy)pyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S,S)-1-(1-(2-(2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)ethyl)-1H-indazol-5-yl)-4-(benzyloxy)pyridin-2(1H)-one(1039826-39-5)
• EPA Substance Registry System: (S,S)-1-(1-(2-(2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)ethyl)-1H-indazol-5-yl)-4-(benzyloxy)pyridin-2(1H)-one(1039826-39-5)

Safety Data

• Hazardous Substances Data: 1039826-39-5(Hazardous Substances Data)

Upstream product

• 53937-02-3 4-(benzyloxy)pyridin-2(1H)-one 
• 1108184-22-0 5-(2-(5-bromo-1H-indazol-1-yl)ethyl)-(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 1039826-10-2 4-(benzyloxy)-1-(1-(2-chloroethyl)-1H-indazol-5-yl)pyridin-2(1H)-one 
• 279-33-4 (1S,4S)-2-oxa-5-aza-bicyclo[2.2.1]heptane 

Relevant articles and documents

5-(Pyridinon-1-yl)indazoles and 5-(furopyridinon-5-yl)indazoles as MCH-1 antagonists

A new series of 5-(pyridinon-1-yl)indazoles with MCH-1 antagonist activity were synthesized. Potential cardiovascular risk for these compounds was assessed based upon their interaction with the hERG potassium channel in a mini-patch clamp assay. Selected compounds were studied in a 5-day diet-induced obese mouse model to evaluate their potential use as weight loss agents. Structural modification of the 5-(pyridinon-1-yl)indazoles to give 5-(furopyridinon-5-yl) indazoles provided compounds with enhanced pharmacokinetic properties and improved efficacy.