279-33-4

Basic information

• Product Name: 2-oxa-5-azabicyclo[2.2.1]heptane
• Synonyms: 2-oxa-5-azabicyclo[2.2.1]heptane;5-Aza-2-oxabicyclo[2.2.1]heptane;5-oxa-2-aza-bicyclo[2.2.1]heptane
• CAS NO: 279-33-4
• Molecular Formula: C₅H₉NO
• Molecular Weight: 99.1321
• Product Categories: CHIRAL CHEMICALS
• Mol File: 279-33-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 154℃
• Flash Point: 46℃
• Appearance: /
• Density: 1.074
• Vapor Pressure: 3.3mmHg at 25°C
• Refractive Index: 1.476
• CAS DataBase Reference: 2-oxa-5-azabicyclo[2.2.1]heptane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxa-5-azabicyclo[2.2.1]heptane(279-33-4)
• EPA Substance Registry System: 2-oxa-5-azabicyclo[2.2.1]heptane(279-33-4)

Safety Data

• Hazardous Substances Data: 279-33-4(Hazardous Substances Data)

Usage

Description

2-Oxa-5-azabicyclo[2.2.1]heptane is a heterocyclic compound characterized by a bicyclic structure containing an oxygen atom and a nitrogen atom. It is a versatile building block in organic synthesis and has potential applications in various fields due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
2-Oxa-5-azabicyclo[2.2.1]heptane is used as a reactant for the preparation of benzopyranones and pyrimidoisoquinolinones, which exhibit DNA-dependent protein kinase inhibitory activity. These compounds have potential applications in the development of novel therapeutic agents for various diseases, including cancer and other conditions where DNA repair mechanisms play a crucial role.

InChI:InChI=1/C5H9NO/c1-4-3-7-5(1)2-6-4/h4-6H,1-3H2

Upstream product

• 31560-05-1 5-benzyl-2-oxa-5-aza-bicyclo[2.2.1]heptane 
• 31337-88-9 5-benzoyl-2-oxa-5-aza-bicyclo[2.2.1]heptane 
• 51-35-4 4R-4-hydroxyproline 
• 64187-48-0 methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate 
• 117811-78-6 methyl (2S,4R)-1-benzyloxycarbonyl-4-methanesulfonyloxypyrrolidine-2-carboxylate 
• 1527519-52-3 (2S,4S)-1-benzyl 2-methyl 4-(benzoyloxy)pyrrolidine-1,2-dicarboxylate 
• 57653-35-7 (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylic acid 1-benzyl 2-methyl 
• 194933-51-2 (2S,4S)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-1,2-dicarboxylic acid 1-benzyl-2-methyl 
• 123232-10-0 (2S,4S)-benzyl 4-(tert-butyldimethylsilyloxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 1527519-57-8 (2S,4S)-benzyl 4-(tert-butyldimethylsilyloxy)-2-((methylsulfonyloxy)methyl)pyrrolidine-1-carboxylate 
• 1527519-61-4 C₁₄H₁₉NO₆S 
• 1527519-59-0 (1S,4S)-benzyl 2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate 
• 57653-38-0 N-<(phenylmethoxy)carbonyl>-4(R)-<<(4-methylphenyl)sulfonyl>oxy>-(S)-proline methyl ester 
• 57653-36-8 (2S,4R)-1-benzyloxycarbonyl-2-hydroxymethyl-4-(tosyloxy)pyrrolidine 

Downstream Products

• 743438-26-8 2-(2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-ethanol 
• 1056877-55-4 C₃₁H₃₅ClN₆O₃ 
• 1125598-23-3 methyl 4-(2-{1-benzhydryl-5-chloro-2-[2-({[2-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl)ethyl]sulfonyl}amino)ethyl]-1H-indol-3-yl}ethoxy)benzoate 
• 1215098-11-5 (E)-[2-(3-{4-[1-(4-Bromo-phenylcarbamoyl)-3-({1S,4S}-2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-propyl]phenyl}-acryloylamino)-phenyl]-carbamic acid tert-butyl ester 
• 1215098-37-5 2-(5-bromo-pyridin-2-yl)-5-({1S,4S}-2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl)-pentanoic acid (4-bromo-phenyl)-amide 
• 1243675-19-5 C₃₈H₄₈ClF₂N₃O₃ 
• 1039826-39-5 (S,S)-1-(1-(2-(2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)ethyl)-1H-indazol-5-yl)-4-(benzyloxy)pyridin-2(1H)-one 
• 1352620-95-1 (4-bromo-3-methoxyphenyl)[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl]-methanone 
• 1352619-78-3 2-(4-fluorophenyl)-N-{4-[2-({2-methoxy-4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylcarbonyl]phenyl}amino)[1.2.4]triazolo[1,5-a]pyridin-6-yl]phenyl}acetamide 
• 1352620-19-9 N-(4-fluorobenzyl)-4-[2-({2-methoxy-4-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylcarbonyl]phenyl}amino)[1.2.4]triazolo[1,5-a]pyridin-6-yl]benzamide 
• 1355004-02-2 (1S,4S)-5-({1-[4-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}methyl)-2-oxa-5-azabicyclo[2.2.1]heptane 
• 1355004-03-3 4-{5-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-ylmethyl]-1H-tetrazol-1-yl}-2-(trifluoromethyl)benzonitrile 
• 1445884-24-1 C₁₉H₁₇N₅OS 
• 1439358-09-4 C₁₈H₂₀N₄O₄S 

Relevant articles and documents

As Aurora kinase inhibitor derivatives

The present invention relates to a substituted pyrazole derivative used for inhibiting Aurora kinase and represented by formula (I) or formula (Ia), or stereo isomers, geometric isomers, tautomers, nitrogen oxides, hydrates, solvates, metabolites, esters, pharmaceutically acceptable salts or prodrugs thereof, a medicinal composition containing the above compounds as active ingredients, and a use of the compounds and the medicinal composition in preparation of medicines for protecting, processing, treating or mitigating proliferative diseases of patients.

PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF

The present invention relates to phenyl amino pyrimidine bicyclic compounds formula (I) which are inhibitors of protein kinases including JAK kinases. In particular the compounds are active against JAK1, JAK2, JAK3 and TYK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

Stereochemical studies on medicinal agents. 9. Bicyclic bases. Synthesis and biological activities of epimeric quaternary derivatives of 2-oxa-5-azabicyclo [2.2.1]heptane.

-