194933-51-2Relevant articles and documents
Enantioselective Construction of Octahydroquinolines via Trienamine-Mediated Diels-Alder Reactions
Inoshita, Taichi,Goshi, Kei,Morinaga, Yuka,Umeda, Yuhei,Ishikawa, Hayato
, p. 2903 - 2907 (2019)
A trienamine-mediated asymmetric Diels-Alder reaction using a 5-nitro-2,3-dihydro-4-pyridone derivative as a dienophile in the presence of a secondary amine organocatalyst derived from cis-hydroxyproline was discovered. The reaction provides optically act
PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF
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, (2014/01/17)
The present invention relates to phenyl amino pyrimidine bicyclic compounds formula (I) which are inhibitors of protein kinases including JAK kinases. In particular the compounds are active against JAK1, JAK2, JAK3 and TYK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.
Developing microcolin A analogs as biological probes
Mandal, Amit K.,Hines, John,Kuramochi, Kouji,Crews, Craig M.
, p. 4043 - 4047 (2007/10/03)
Three microcolin A and B analogs have been synthesized. Their biological activity profiles were evaluated against several cell lines, revealing the existence of a structural determinant whose role in mediating the antiproliferative effect of the microcoli