104351-40-8 Usage
Description
(S,S)-N-Benzyl-3,4-trans-dimesolate pyrrolidine is a complex chemical compound that features a dimesolate derivative of pyrrolidine, a heterocyclic compound with a five-membered ring composed of three carbon atoms and one nitrogen atom. The addition of a benzyl group to the nitrogen atom enhances the stability of the molecule, which is significant for its applications in organic synthesis and pharmaceuticals. The (S,S)-configuration denotes the stereochemistry of the compound, specifying the spatial arrangement of its two chiral centers. This makes (S,S)-N-Benzyl-3,4-trans-dimesolate pyrrolidine a valuable chemical building block with a broad spectrum of potential uses in various industries and scientific research.
Uses
Used in Organic Synthesis:
(S,S)-N-Benzyl-3,4-trans-dimesolate pyrrolidine serves as a key intermediate in organic synthesis, particularly for the creation of complex organic molecules. Its unique structure and stability make it a versatile component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Applications:
In the pharmaceutical industry, (S,S)-N-Benzyl-3,4-trans-dimesolate pyrrolidine is utilized as a building block for the development of new drugs. Its specific stereochemistry and molecular structure contribute to the design of innovative therapeutic agents with targeted effects and improved pharmacological properties.
Used in Research and Development:
(S,S)-N-Benzyl-3,4-trans-dimesolate pyrrolidine is also employed in research and development settings to explore its potential in various chemical reactions and to understand its behavior under different conditions. This knowledge can lead to the discovery of new applications and improvements in existing processes.
Used in Chiral Compounds Production:
Due to its chiral nature, (S,S)-N-Benzyl-3,4-trans-dimesolate pyrrolidine is used in the production of chiral compounds, which are essential in many biological and chemical processes. The specific stereochemistry allows for the creation of enantiomerically pure substances, which are crucial for the development of effective and safe medications.
Used in Material Science:
In material science, (S,S)-N-Benzyl-3,4-trans-dimesolate pyrrolidine can be incorporated into the design of new materials with unique properties. Its molecular structure may contribute to the development of advanced materials for use in various industries, such as electronics, coatings, and plastics.
Check Digit Verification of cas no
The CAS Registry Mumber 104351-40-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,3,5 and 1 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 104351-40:
(8*1)+(7*0)+(6*4)+(5*3)+(4*5)+(3*1)+(2*4)+(1*0)=78
78 % 10 = 8
So 104351-40-8 is a valid CAS Registry Number.
104351-40-8Relevant articles and documents
Design of a C2-symmetric chiral pyrrolidine-based amino sulfonamide: application to anti-selective direct asymmetric Mannich reactions
Kano, Taichi,Hato, Yoshio,Maruoka, Keiji
, p. 8467 - 8469 (2006)
The anti-selective direct asymmetric Mannich reaction was found to be efficiently catalyzed by the novel pyrrolidine-based amino sulfonamide (R,R)-2 prepared from l-tartaric acid.
Investigation of stereoisomeric bisarylethenesulfonic acid esters for discovering potent and selective PTP1B inhibitors
Xie, Fangzhou,Yang, Fengzhi,Liang, Yaoyao,Li, Liang,Xia, Yu,Jiang, Faqin,Liu, Wenlu,Qi, Yunyue,Chowdhury, Sharmin Reza,Xie, Dongsheng,Fu, Lei
, p. 408 - 422 (2019/01/08)
Protein tyrosine phosphatase 1B (PTP1B) has been considered as a promising therapeutic target for type 2 diabetes mellitus (T2DM) and obesity due to its key regulating effects in insulin signaling and leptin receptor pathways. In this work, a series of cis- and trans-pyrrolidine bisarylethenesulfonic acid esters were prepared and their PTP1B inhibitory potency, selectivity and membrane permeability were evaluated. These novel stereoisomeric molecules especially trans-isomers exhibited remarkable inhibitory activity, significant selectivity as well as good membrane permeability (e.g. compound 28a, IC50 = 120, 1940 and 2670 nM against PTP1B, TCPTP and SHP2 respectively, and Papp = 1.74 × 10?6 cm/s). Molecular simulations indicated that trans-pyrrolidine bisarylethenesulfonic acid esters yielded the stronger binding affinity than their cis-isomers by constructing more interactions with non-catalytic sites of PTP1B. Further biological activity studies revealed that compound 28a could enhance insulin-stimulated glucose uptake and insulin-mediated insulin receptor β (IRβ) phosphorylation with no significant cytotoxicity.
A process for preparing optically active aldehyde or ketone method and catalyst preparation method
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Paragraph 0076; 0077, (2017/04/07)
The invention provides a method for preparing optically active aldehyde or ketone by asymmetric hydrogenation and a preparation method of a catalyst thereof. The optically active aldehyde or ketone is prepared by using a homogeneous and optically active double transition metal catalyst and a chiral amino acid cocatalyst through asymmetric hydrogenation of alpha, beta-unsaturated aldehyde or ketone. The reaction pressure (absolute pressure) is 0.1-10MPa, preferably 5-8MPa; the reaction temperature is 25-90 DEG C; the catalyst is prepared from chiral multi-coordination phosphine-containing ligands and transition metals; chiral amino acid added to the reaction system serves as a cocatalyst; and the reaction selectivity is 95-99%, the conversion rate can reach 85-99.9%, and the optical purity of the product is 80-99ee%.
