1061757-69-4Relevant articles and documents
Synthesis of Malononitrile-Substituted Diarylmethines via 1,6-Addition of Masked Acyl Cyanides to para -Quinone Methides
Zhao, Kun,Zhi, Ying,Wang, Ai,Enders, Dieter
, p. 872 - 880 (2017/11/29)
An efficient method for the synthesis of malononitrile-substituted diarylmethines through 1,6-conjugate addition of para -quinone methides with masked acyl cyanide (MAC) reagents has been developed. Under mild conditions, the scalable reaction occurs in good to excellent yields providing a straightforward access to a series of malononitrile-substituted diarylmethines. The synthetic utility of this protocol has been demonstrated in the synthesis of bioactive compounds.
Novel sterically hindered cannabinoid CB1 receptor ligands
Urbani, Paolo,Cascio, Maria Grazia,Ramunno, Anna,Bisogno, Tiziana,Saturnino, Carmela,Marzo, Vincenzo Di
, p. 7510 - 7515 (2008/12/23)
In the present study, 11 novel N-(3,3-diphenyl)propyl-2,2-diphenylacetamide derivatives (4a-d and 9a-g) and six triphenylacetamides (10a-c and 11a-c) were synthesized and tested as ligands of cannabinoid CB1 and CB2 receptors. All co