7699-03-8

Basic information

• Product Name: (4-hydroxyphenyl)(phenyl)acetic acid
• CAS NO: 7699-03-8
• Molecular Formula: C₁₄H₁₂O₃
• Molecular Weight: 228.2433
• Mol File: 7699-03-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 404.2°C at 760 mmHg
• Flash Point: 212.4°C
• Density: 1.274g/cm³
• Vapor Pressure: 2.94E-07mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: (4-hydroxyphenyl)(phenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (4-hydroxyphenyl)(phenyl)acetic acid(7699-03-8)
• EPA Substance Registry System: (4-hydroxyphenyl)(phenyl)acetic acid(7699-03-8)

Safety Data

• Hazardous Substances Data: 7699-03-8(Hazardous Substances Data)

Usage

Description

(4-Hydroxyphenyl)(phenyl)acetic acid, also known as 3-(4-hydroxyphenyl)phenylacetic acid, is a compound with the chemical formula C14H12O3. It is a derivative of both phenol and acetic acid, featuring a hydroxyphenyl group and a phenylacetic acid group. This versatile molecule has attracted attention for its potential applications in various fields, particularly medicine and chemistry, due to its anti-inflammatory, antioxidant properties, and its use as a precursor in the synthesis of pharmaceuticals and other organic compounds.

Uses

Used in Pharmaceutical Synthesis:
(4-Hydroxyphenyl)(phenyl)acetic acid is used as a precursor in the pharmaceutical industry for the synthesis of various drugs and organic compounds. Its unique structure allows for the creation of a wide range of molecules with different therapeutic properties.
Used in Anti-Inflammatory Applications:
In the medical field, (4-hydroxyphenyl)(phenyl)acetic acid is used as an anti-inflammatory agent. Its potential to alleviate inflammation makes it a valuable compound for the development of treatments for conditions characterized by inflammation, such as arthritis and other autoimmune diseases.
Used in Antioxidant Applications:
(4-Hydroxyphenyl)(phenyl)acetic acid is also used as an antioxidant, helping to protect cells from damage caused by reactive oxygen species. Its antioxidant properties make it a promising candidate for the development of treatments for conditions associated with oxidative stress, such as neurodegenerative diseases and cardiovascular disorders.
Used in Diabetes and Metabolic Disorder Treatment:
Furthermore, (4-hydroxyphenyl)(phenyl)acetic acid has been investigated for its potential use in the treatment of diabetes and other metabolic disorders. Its ability to modulate metabolic pathways could lead to the development of novel therapies for these conditions.

Upstream product

• 120264-80-4 2,2-bis(4-methoxyphenyl)-2-phenylacetonitrile 
• 611-71-2 MANDELIC ACID 
• 108-95-2 phenol 
• 532-28-5 (RS)-mandelonitrile 
• 7664-93-9 sulfuric acid 
• 7732-18-5 water 
• 10034-85-2 hydrogen iodide 
• 613-90-1 benzoyl cyanide 
• 100-66-3 methoxybenzene 
• 71-43-2 benzene 
• 22979-35-7 Methyl phenyldiazoacetate 
• 54775-13-2 1-(4-hydroxyphenyl)-1-methoxycarbonyl-1-phenylmethane 
• 7078-98-0 2,6-di-tert-butyl-4-benzylidene-cyclohexa-2,5-dienone 
• 6000-59-5 glyoxalic acid monohydrate 

Downstream Products

• 1220911-33-0 2-(4-hydroxyphenyl)-2-phenyl-N-(3-phenylpropyl)acetamide 
• 1061757-69-4 N-(3,3-diphenylpropyl)-2-(4-hydroxyphenyl)-2-phenylacetamide 

Relevant articles and documents

Structure-Based Design of High-Affinity Fluorescent Probes for the Neuropeptide Y Y1Receptor

The recent crystallization of the neuropeptide Y Y1 receptor (Y1R) in complex with the argininamide-type Y1R selective antagonist UR-MK299 (2) opened up a new approach toward structure-based design of nonpeptidic Y1R ligands. We designed novel fluorescent probes showing excellent Y1R selectivity and, in contrast to previously described fluorescent Y1R ligands, considerably higher (～100-fold) binding affinity. This was achieved through the attachment of different fluorescent dyes to the diphenylacetyl moiety in 2 via an amine-functionalized linker. The fluorescent ligands exhibited picomolar Y1R binding affinities (pKi values of 9.36-9.95) and proved to be Y1R antagonists, as validated in a Fura-2 calcium assay. The versatile applicability of the probes as tool compounds was demonstrated by flow cytometry- and fluorescence anisotropy-based Y1R binding studies (saturation and competition binding and association and dissociation kinetics) as well as by widefield and total internal reflection fluorescence (TIRF) microscopy of live tumor cells, revealing that fluorescence was mainly localized at the plasma membrane.

Synthesis of Malononitrile-Substituted Diarylmethines via 1,6-Addition of Masked Acyl Cyanides to para -Quinone Methides

An efficient method for the synthesis of malononitrile-substituted diarylmethines through 1,6-conjugate addition of para -quinone methides with masked acyl cyanide (MAC) reagents has been developed. Under mild conditions, the scalable reaction occurs in good to excellent yields providing a straightforward access to a series of malononitrile-substituted diarylmethines. The synthetic utility of this protocol has been demonstrated in the synthesis of bioactive compounds.