106467-09-8

Basic information

• Product Name: N-Benzoyl-N'-[2-(2-dimethylaminomethyl-thiazol-4-ylmethylsulfanyl)-ethyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-guanidine
• CAS NO: 106467-09-8
• Molecular Weight: 485.677
• Mol File: 106467-09-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-Benzoyl-N'-[2-(2-dimethylaminomethyl-thiazol-4-ylmethylsulfanyl)-ethyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-guanidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzoyl-N'-[2-(2-dimethylaminomethyl-thiazol-4-ylmethylsulfanyl)-ethyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-guanidine(106467-09-8)
• EPA Substance Registry System: N-Benzoyl-N'-[2-(2-dimethylaminomethyl-thiazol-4-ylmethylsulfanyl)-ethyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-guanidine(106467-09-8)

Safety Data

• Hazardous Substances Data: 106467-09-8(Hazardous Substances Data)

Upstream product

• 78441-62-0 4-[[(2-aminoethyl)thio]-methyl]-N,N-dimethyl-2-thiazolemethanamine 
• 81282-38-4 N-diphenoxymethylene benzamide 
• 40546-33-6 3-[imidazol-4⁽⁵⁾-yl]propylamine 
• 112758-49-3 1-Benzoyl-3-[2-(2-dimethylaminomethyl-thiazol-4-ylmethylsulfanyl)-ethyl]-2-phenyl-isourea 

Relevant articles and documents

Synthesis and pharmacological activity of substituted imidazolyl- and thiazolylmethylthioethylguanidines

Starting with diphenyl N-benzoyl-carbonimidate impromidine analogues characterized by various substituted imidazole or thiazole groups instead of the 5-methylimidazole part have been synthesized and tested for H2-agonistic and H1-antagonistic activity as well. The most potent substances 6h,i are 20-30 times more active than histamine at the H1-receptors in the isolated spontaneously beating guinea-pig right atrium. In isolated perfused guinea-pig hearts 6h,i were found to predominantly stimulate heart rate, whereas the increase in LVdp/dt(max) was about 40% of impromidine's maximal response.