78441-62-0

Basic information

• Product Name: 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole
• Synonyms: 4-[[(2-aminoethyl)thio]methyl]-N,N-dimethylthiazole-2-methylamine;4-(2-aminoethylthiomethyl)-1,3-thiazol-2-ylmethyldimethylamine;2-(Dimethylaminomethyl)-4-(2-Aminoethylthionmethyl)Thiazole;2-(2-(Dimethylaminomethyl-4-thiazol)methylthio)ethylamine;4-[[(2-Aminoethyl)thio]methyl]-N,N-dimethyl-2-thiazolemethanamine;2-Thiazolemethanamine, 4-(((2-aminoethyl)thio)methyl)-N,N-dimethyl-;Einecs 278-909-9;Nizatidine EP IMpurity D
• CAS NO: 78441-62-0
• Molecular Formula: C₉H₁₇N₃S₂
• Molecular Weight: 231.38138
• EINECS: 278-909-9
• Product Categories: Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 78441-62-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 338.905 °C at 760 mmHg
• Flash Point: 158.764 °C
• Appearance: /
• Density: 1.182 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• PKA: 8.83±0.10(Predicted)
• CAS DataBase Reference: 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole(78441-62-0)
• EPA Substance Registry System: 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole(78441-62-0)

Safety Data

• Hazardous Substances Data: 78441-62-0(Hazardous Substances Data)

Usage

Chemical Properties

Brown Liquid

Uses

Different sources of media describe the Uses of 78441-62-0 differently. You can refer to the following data:
1. 2-(Dimethylaminomethyl)-4-(2-aminoethylthiomethyl)thiazole (Nizatidine EP Impurity D) is a Nizatidine intermediate.
2. Nizatidine intermediate.

InChI:InChI=1/C9H17N3S2/c1-12(2)5-9-11-8(7-14-9)6-13-4-3-10/h7H,3-6,10H2,1-2H3

Upstream product

• 156-57-0 2-mercaptoethylamine hydrochloride 
• 78441-69-7 2-dimethylaminomethyl-4-hydroxymethylthiazole 
• 82586-66-1 ethyl 2-(dimethylaminomethyl)-4-thiazolecarboxylate 
• 140176-73-4 4-chloromethyl-2-dimethylaminomethylthiazole 
• 82586-71-8 2-dimethylaminomethyl-4-thiazolylmethylchloride hydrochloride 
• 92759-37-0 4-Hydroxy-4-(chloromethyl)-2-<(dimethylamino)methyl>thiazoline 

Downstream Products

• 112758-49-3 1-Benzoyl-3-[2-(2-dimethylaminomethyl-thiazol-4-ylmethylsulfanyl)-ethyl]-2-phenyl-isourea 
• 106467-09-8 N-Benzoyl-N'-[2-(2-dimethylaminomethyl-thiazol-4-ylmethylsulfanyl)-ethyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-guanidine 
• 76963-41-2 nizatidine 
• 82586-81-0 N-methyl-N'-2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethylurea 
• 82586-82-1 N-methyl-N'-2-([2-(dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl-N-p-tolylsulfonylguanidine 
• 82586-82-1 N-methyl-N'-2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethyl-N-p-tolylsulfonylguanidine 
• 87767-28-0 2-[2-(2-dimethylaminomethyl-4-thiazolylmethylthio)ethyl]amino-5-(3-pyridyl)methoxy-4-pyrimidone 

Relevant articles and documents

Preparation method of nizatidine bulk drug

The invention discloses a preparation method of a nizatidine bulk drug. The preparation method comprises the following steps: (1) preparing 2-(N,N-dimethylamino)-4-chloromethyl-4-hydroxy-4,5-dihydrothiazole (III); (2) preparing 2-(N,N-dimethylamino)-4-thiazolemethanol (IV); (3) preparing 2-(dimethylaminomethyl)-4-(2-aminoethylthiomethyl) thiazole (V); and (4) preparing nizatidine. The preparation method has the beneficial effects that the cost is low, the preparation process is simple, the yield is high, and the prepared nizatidine is high in purity.

HISTAMINE H2-ANTAGONISTS

Histamine H 2-antagonists of the formula STR1 wherein p is 1 or 2; R 1 is hydroxy, amino, substituted amino or a 5-to 9-membered fully saturated nitrogen-containing heterocyclic ring attached via its nitrogen atom; m is an integer of from 0 to 2, n is an integer of from 2 to 4; Z is sulfur, oxygen or methylene; and A is an optionally substituted phenyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, oxadiazolyl, furyl, thienyl or pyridyl ring; and nontoxic pharmaceutically acceptable salts, hydrates, solvates or N-oxides thereof are novel anti-ulcer agents. Intermediates and processes for their preparation are disclosed.

2-[2-(2-AMINOALKYL-4-THIAZOLYLMETHYLTHIO)ALKYL]-AMINO-5-SUBSTITUTED-4-PYRIMIDONES

2-2-(2-aminoalkyl-4-thiazolylmethylthio)-alkylene!amino-5-aromatic-substitute d alkylene-4-pyrimidones and related compounds, H. sub.2 receptor antagonists, useful in inhibiting gastric acid secretion in mammals.