140176-73-4

Basic information

• Product Name: N-{[4-(chloromethyl)-1,3-thiazol-2-yl]methyl}-N,N-dimethylamine
• Synonyms: N-{[4-(chloromethyl)-1,3-thiazol-2-yl]methyl}-N,N-dimethylamine;4-(chloromethyl)-N,N-dimethyl-2-Thiazolemethanamine
• CAS NO: 140176-73-4
• Molecular Formula: C₇H₁₁ClN₂S
• Molecular Weight: 190.69364
• Mol File: 140176-73-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-{[4-(chloromethyl)-1,3-thiazol-2-yl]methyl}-N,N-dimethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-{[4-(chloromethyl)-1,3-thiazol-2-yl]methyl}-N,N-dimethylamine(140176-73-4)
• EPA Substance Registry System: N-{[4-(chloromethyl)-1,3-thiazol-2-yl]methyl}-N,N-dimethylamine(140176-73-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 140176-73-4(Hazardous Substances Data)

Upstream product

• 92759-37-0 4-Hydroxy-4-(chloromethyl)-2-<(dimethylamino)methyl>thiazoline 

Downstream Products

• 78441-62-0 4-[[(2-aminoethyl)thio]-methyl]-N,N-dimethyl-2-thiazolemethanamine 

Relevant articles and documents

Synthesis method of nizatidine drug intermediate 2-dimethylamino methyl-4-chloromethyl thiazole

A synthesis method of a nizatidine drug intermediate 2-dimethylamino methyl-4-chloromethyl thiazole includes the following steps that 0.063 mol of 2-dimethylamino methyl-4-chloromethyl-4-aminothiazoline, 310 ml of cyclohexane, 0.92 mol of stannous chloride and 0.16-0.19 mol of an ortho-nitrotoluene solution are added into a reaction vessel provided with a stirrer and a thermometer, the stirring speed is controlled to be 150-190 rpm, the solution temperature is controlled to be 10-15 DEG C, reaction is performed for 20-25 hours, then the temperature is raised to 60-65 DEG C, the reaction continues for 4-5 hours, the solution temperature is reduced to 20-25 DEG C, solid precipitation, filtration, washing with a saline solution, washing with acetonitrile and dehydration with a dehydrating agent are performed, and recrystallization is performed in triethylamine to obtain the crystal 2-dimethylamino methyl-4-chloromethyl thiazole.

A modified synthesis of 4-chloromethylthiazoles

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