82586-71-8Relevant articles and documents
Spectroscopic Evidence for a Spirooxirane Intermediate in the Synthesis of 4-(Hydroxymethyl)-2-thiazole
Johnson, Ross A.,Moder, Kenneth P.,Ward, Timothy L.
, p. 2869 - 2872 (2007/10/02)
The synthesis of 4-(hydroxymethyl)thiazole derivatives from the corresponding 4-(chloromethyl)-4-hydroxythiazole derivatives have been speculated to proceed through spirooxirane intermediates.NMR spectroscopy was used to provide evidence for the existence of such an intermediate in the synthesis of 4-(hydroxymethyl)-2-thiazole.Experimental conditions for the optimum formation and stabilization of a suspect intermediate were determined and spectral data obtained to support the speculated structure.Comparison were made between couplings constants predicted in molecular models and the experimental data.
N-THIAZOLYLMETHYLTHIOALKYL-N`-ALKENYL (OR ALKYNYL)GUANIDINES AND RELATED COMPOUNDS
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, (2008/06/13)
N-alkenyl (or N-alkynyl)-N'-2-(aminoalkyl)-4-thiazolylmethylthio!alkylguanidines, thioureas, ethenediamines and related compounds, H 2 receptor antagonists, useful in inhibiting gastric acid secretion in mammals.