1070892-04-4

Basic information

• Product Name: 5-bromo-2-(trifluoromethyl)isonicotinonitrile
• Synonyms: 5-bromo-2-(trifluoromethyl)isonicotinonitrile
• CAS NO: 1070892-04-4
• Molecular Formula: C₇H₂BrF₃N₂
• Molecular Weight: 251
• Mol File: 1070892-04-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 254.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.81±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -5.19±0.30(Predicted)
• CAS DataBase Reference: 5-bromo-2-(trifluoromethyl)isonicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-(trifluoromethyl)isonicotinonitrile(1070892-04-4)
• EPA Substance Registry System: 5-bromo-2-(trifluoromethyl)isonicotinonitrile(1070892-04-4)

Safety Data

• Hazardous Substances Data: 1070892-04-4(Hazardous Substances Data)

Usage

General Description

5-bromo-2-(trifluoromethyl)isonicotinonitrile is a chemical compound with the molecular formula C7H2BrF3N2. It is a white to off-white solid that is widely used as a synthetic intermediate in the pharmaceutical industry. 5-bromo-2-(trifluoromethyl)isonicotinonitrile is a potent inhibitor of the cytochrome P450 enzyme, making it useful in drug metabolism studies and as a potential drug candidate for treating various diseases. It is also used as a building block in the synthesis of other organic compounds, particularly in the development of new drugs and agrochemicals. Additionally, 5-bromo-2-(trifluoromethyl)isonicotinonitrile exhibits antimicrobial and antifungal activity, making it a versatile and important chemical in the field of medicinal chemistry.

Upstream product

• 1070892-03-3 5-bromo-2-trifluoromethylisonicotinamide 
• 436799-32-5 5-bromo-2(trifluoromethyl)pyridine 
• 749875-16-9 5-bromo-2-(trifluoromethyl)pyridine-4-carboxylic acid 
• 1070972-53-0 C₇H₂BrClF₃NO 

Downstream Products

• 1070973-29-3 5-(2-chloro-4-methoxy-phenyl)-2-trifluoromethylisonicotinonitrile 
• 1070973-01-1 4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(2,3,4,5-tetrahydro-benzo[b]azepine-1-sulfonyl)-phenoxy]-butyric acid tert-butyl ester 
• 1070973-14-6 5-[2-chloro-5-(4,4-dimethyl-3,4-dihydro-2H-quinoline-1-sulfonyl)-4-(4-hydroxy-butoxy)-phenyl]-2-trifluoromethyl-isonicotinonitrile 
• 1070973-54-4 4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(4-hydroxy-butoxy)-N-methyl-N-pyridin-2-yl-benzenesulfonamide 
• 1070892-55-5 4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(methyl-o-tolyl-carbamoyl)-phenoxy]-butyric acid tert-butyl ester 
• 1070892-92-0 4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-methoxy-benzoic acid 
• 1070892-93-1 4-chloro-2-methoxy-5-(6-trifluoromethyl-pyridin-3-yl)-benzoyl chloride 
• 1070891-28-9 4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-N-(2,6-dimethyl-phenyl)-2-methoxy-N-methyl-benzamide 
• 1070892-94-2 4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-N-(2,6-dimethyl-phenyl)-2-methoxy-benzamide 
• 1070890-41-3 4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(methyl-o-tolyl-carbamoyl)-phenoxy]-butyric acid 
• 1070973-30-6 4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-methoxy-benzenesulfonyl chloride 
• 1070973-28-2 4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-methoxy-N-methyl-N-phenyl-benzenesulfonamide 
• 1070973-61-3 4-chloro-5-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-hydroxy-N-methyl-N-phenyl-benzenesulfonamide 
• 1070973-59-9 [5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(methyl-phenyl-sulfamoyl)-phenoxy]-acetic acid 

Relevant articles and documents

IMIDAZOPYRIMIDINES AS EED INHIBITORS AND THE USE THEREOF

The present disclosure provides compounds represented by Formula (I) wherein R1, R2, R3, and R4 are as defined in the specification, and the salts and solvates thereof. Compounds of Formula (I) are FED inhibitors. FED inhibitors are useful for the treatment of cancer and other diseases.

GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure, wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.