107325-60-0Relevant articles and documents
Optical Resolution of Propafenone and Diprafenone, Configuration of Propafenone Enantiomers
Blaschke, Gottfried,Walther, Bernd
, p. 561 - 564 (2007/10/02)
The chiral antiarrhythmic drugs propafenone (rac-1) and diprafenone (rac-3) were resolved by fractional crystallization of the diastereoisomeric salts with optically active di-O,O'-p-toluoyltartaric acid and tartaric acid, respectively.Derivatization with (+)-1-phenylethyl isocyanate and analytical separation of the diastereoisomers 2 and 4 by HPLC confirmed the optical purity of the enantiomers.CD spectra of (+)- and (-)-propafenone as copper complexes established the absolute configuration: (-)-1 is R-, (+)-1 S-configurated.