107381-32-8

Basic information

• Product Name: (S)-Propafenone
• Synonyms: (-)-(S)-Propafenone;(S)-Propafenone;1-Propanone, 1-[2-[(2S)-2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl- (9CI);1-Propanone, 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, (S)-;(-)-Propafenon;1-[2-[(S)-2-Hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone;2'-[(2S)-2-Hydroxy-3-(propylamino)propoxy]-β-phenylpropiophenone;1-[2-[(2S)-2-hydroxy-3-(propylaMino)propoxy]phenyl]-3-phenyl-
• CAS NO: 107381-32-8
• Molecular Formula: C₂₁H₂₇NO₃
• Molecular Weight: 341.448
• Product Categories: Amines;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 107381-32-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 519.6°Cat760mmHg
• Flash Point: 268°C
• Appearance: /
• Density: 1.096g/cm³
• Vapor Pressure: 1.27E-11mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (S)-Propafenone(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-Propafenone(107381-32-8)
• EPA Substance Registry System: (S)-Propafenone(107381-32-8)

Safety Data

• Hazardous Substances Data: 107381-32-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3/t18-/m0/s1

Upstream product

• 107300-59-4 propafenone 
• 74748-75-7 (S)-(+)-<<(trifluoromethanesulfonyl)oxy>methyl>oxirane 
• 3516-95-8 2'-hydroxy-3-phenylpropiophenone 

Downstream Products

• 107325-60-0 1-{(S)-2-Hydroxy-3-[2-(3-phenyl-propionyl)-phenoxy]-propyl}-3-((R)-1-phenyl-ethyl)-1-propyl-urea 

Relevant articles and documents

Colistin sulfate chiral stationary phase for the enantioselective separation of pharmaceuticals using organic polymer monolithic capillary chromatography ?

A new functionalized polymer monolithic capillary with a macrocyclic antibiotic, namely colistin sulfate, as chiral selector was prepared via the copolymerization of binary monomer mixtures consisting of glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in porogenic solvents namely 1-propanol and 1,4-butanediol, in the presence of azobisiso-butyronitrile (AIBN) as initiator and colistin sulfate. The prepared capillaries were investigated for the enantioselective nano-LC separation of a group of racemic pharmaceuticals, namely, α- and β-blockers, anti-inflammatory drugs, antifungal drugs, norepinephrine-dopamine reuptake inhibitors, catecholamines, sedative hypnotics, antihistaminics, anticancer drugs, and antiarrhythmic drugs. Acceptable separation was achieved for many drugs using reversed phase chromatographic conditions with no separation achieved under normal phase conditions. Colistin sulfate appears to be useful addition to the available macrocyclic antibiotic chiral phases used in liquid chromatography.

Therapeutic agents containing enantiomers of propafenone

Therapeutic agents containing enantiomers of propafenone, the preparation of the said agents and their use for certain groups of patients.