1076199-24-0Relevant articles and documents
1 - [2 - amino - 1 - (4 - benzyloxy-phenyl) ethyl] preparation method of the cyclohexane is mellow and related intermediates
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Paragraph 0043; 0044, (2017/10/06)
The present invention relates to a preparation method and related intermediates of 1-[2-amino-1-(4-benzyloxyphenyl)-ethyl]-cyclohexanol. The preparation method comprises: taking a compound represented by formula A as raw material, firstly preparing to generate an intermediate compound represented by formula B1 and an intermediate compound represented by formula B2, then taking off a protecting group of the compound represented by the formula B2 to obtain a 1-[2-amino-1-(4-benzyloxyphenyl)-ethyl]-cyclohexanol acid addition salt represented by formula D, and further preparing to obtain 1-[2-amino-1-(4-benzyloxyphenyl)-ethyl]-cyclohexanol. Compared with a conventional method, the raw materials of the method are easy to get and low in price, the product has good quality and high yield, and the method is more suitable for industrialized production.