149289-29-2 Usage
Description
1-[2-amino-1-(4-hydroxyphenyl)ethyl]cyclohexanol is a complex organic compound with a unique molecular structure that features a cyclohexanol core, an amino group, and a hydroxyphenylethyl side chain. This molecule is characterized by its potential for hydrogen bonding and its ability to interact with various biological targets due to its functional groups.
Uses
Used in Pharmaceutical Industry:
1-[2-amino-1-(4-hydroxyphenyl)ethyl]cyclohexanol is used as a lead compound for the development of new drugs targeting various medical conditions. Its unique structure allows it to potentially modulate multiple biological pathways and interact with different receptors, making it a versatile candidate for drug discovery.
Used in Antidepressant Applications:
As a metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor, 1-[2-amino-1-(4-hydroxyphenyl)ethyl]cyclohexanol is used as an antidepressant. It is believed to contribute to the therapeutic effects of Venlafaxine by modulating the levels of serotonin and noradrenaline in the brain, thereby helping to alleviate symptoms of depression and anxiety.
Used in Drug Delivery Systems:
1-[2-amino-1-(4-hydroxyphenyl)ethyl]cyclohexanol can also be utilized in the development of drug delivery systems, where its ability to form hydrogen bonds and interact with biological targets can be exploited to improve the delivery, bioavailability, and efficacy of various therapeutic agents. This application could be particularly useful in enhancing the performance of existing drugs or in the development of novel therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 149289-29-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,9,2,8 and 9 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 149289-29:
(8*1)+(7*4)+(6*9)+(5*2)+(4*8)+(3*9)+(2*2)+(1*9)=172
172 % 10 = 2
So 149289-29-2 is a valid CAS Registry Number.
149289-29-2Relevant articles and documents
Synthesis method of venlafaxine
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Paragraph 0028; 0034; 0037; 0039; 0042; 0044; 0047, (2021/09/21)
The invention relates to the technical field of drug synthesis, in particular to a synthesis method of venlafaxine. The synthesis method comprises first steps of using p-hydroxyphenylacetonitrile as a raw material, adding an activator under anhydrous conditions, and reacting with cyclohexanone to obtain 2 -cyclohexylene -2 - (4 hydroxybenzene) acetonitrile. 2nd-Step: 2 - Cyclohexylene -2 - (4 hydroxybenzene) acetonitrile was oxidized with peracetic acid to give an epoxy compound. 3rd: The epoxy compound is added with catalyst Raney nickel, potassium hydroxide assisted catalysis and high pressure hydrogenation to obtain amino. 4th: The amino is then reacted Eschweiler-Clarke, i.e. the amino is reacted with a - formaldehyde system in formic acid to give a desvenlafaxine. The method has the advantages of high environmental friendliness, low production cost, simple steps, mild reaction conditions and high total yield of 74% or more, and is suitable for large-scale industrial production.
DERIVATIVES OF (-)-VENLAFAXINE AND METHODS OF PREPARING AND USING THE SAME
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Paragraph 0101, (2015/11/23)
Methods of preparing, and compositions comprising, derivatives of (?)-venlafaxine are disclosed. Also disclosed are methods of treating and preventing diseases and disorders including, but not limited to, affective disorders such as depression, bipolar and manic disorders, attention deficit disorder, attention deficit disorder with hyperactivity, Parkinson's disease, epilepsy, cerebral function disorders, obesity and weight gain, incontinence, dementia and related disorders.
PROCESS FOR SYNTHESIZING DESVENLAFAXINE FREE BASE AND SALTS OR SOLVATES THEREOF
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Page/Page column 3, (2010/06/11)
The invention relates generally to an improved process for manufacturing desvenlafaxine free base and salts or solvates thereof.
