1088-84-2

Basic information

• Product Name: Methanone, phenyl(4-phenyl-1H-imidazol-2-yl)-
• CAS NO: 1088-84-2
• Molecular Formula: C16H12N2O
• Molecular Weight: 248.284
• Mol File: 1088-84-2.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: Methanone, phenyl(4-phenyl-1H-imidazol-2-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, phenyl(4-phenyl-1H-imidazol-2-yl)-(1088-84-2)
• EPA Substance Registry System: Methanone, phenyl(4-phenyl-1H-imidazol-2-yl)-(1088-84-2)

Safety Data

• Hazardous Substances Data: 1088-84-2(Hazardous Substances Data)

Upstream product

• 1075-06-5 2,2-dihydroxy-1-phenyl-ethanone 
• 1074-12-0 phenylglyoxal hydrate 
• 70-11-1 α-bromoacetophenone 
• 98-86-2 acetophenone 
• 1816-88-2 2-azido-1-phenylethan-1-one 
• 78-67-1 2,2'-azobis(isobutyronitrile) 
• 40178-28-7 1,1-dimethyl-1-phenacylhydrazinium bromide 
• 57-14-7 N,N-Dimethylhydrazine 
• 532-27-4 1-chloroacetophenone 
• 150114-69-5 2-oxo-2-(3,4,5-trimethoxyphenyl)acetaldehyde 
• 104-88-1 4-chlorobenzaldehyde 
• 123-11-5 4-methoxy-benzaldehyde 
• 555-16-8 4-nitrobenzaldehdye 
• 100-52-7 benzaldehyde 

Downstream Products

• 1724-62-5 2-benzyl-4-phenyl-1⁽³⁾H-imidazole 
• 1230-47-3 (4‐bromophenyl)[4‐(4‐bromophenyl)‐1H‐imidazol‐2‐yl]methanone 
• 1388186-35-3 2,8-diphenyl-6-(piperidin-1-yl)imidazo[1,2-a]pyridine 
• 1388186-45-5 C₂₁H₁₉N₃ 
• 1388186-47-7 4-(2,8-diphenylimidazo[1,2-a]pyridin-6-yl)morpholine 
• 1388186-50-2 N,N-diisopropyl-2,8-diphenylimidazo[1,2-a]pyridin-6-amine 
• 1388186-51-3 6-(4-methylpiperazin-1-yl)-2,8-diphenylimidazo[1,2-a]pyridine 
• 1388186-53-5 N-benzyl-N-methyl-2,8-diphenylimidazo[1,2-a]pyridin-6-amine 
• 1388186-20-6 C₂₃H₂₁N₃ 
• 1384177-43-8 phenyl[4-phenyl-1-(prop-2-yn-1-yl)-1H-imidazol-2-yl]methanone 
• 1384177-16-5 phenyl[4-phenyl-1-(prop-2-yn-1-yl)-1H-imidazol-2-yl]methanol 

Relevant articles and documents

Cathodic reduction of phenacyl azides

(matrix presented). The electrochemical reduction of phenacyl azides (1a-e) leads to the formation of 2-aroyl-4-arylimidazoles (2a-e) (70-80% yield). 1a-e were prepared from phenacyl bromides and sodium azide and were reduced in aprotic DMF-LiClO4/s

A novel class for carbonic anhydrases inhibitors and evaluation of their non-zinc binding

In this study, 23 different imidazole derivatives were synthesized, and the inhibitory properties of these derivatives against carbonic anhydrase I and II isoenzymes were investigated for the first time. The inhibition concentrations of the imidazole derivatives were found to be in the range of 2.89–115.5 nM. Docking studies examined the binding properties of the imidazole derivatives, and the structure–activity relationship is discussed. Theoretical calculations showed that the binding mode of the imidazole ring was non-zinc binding.

Regiodivergent synthesis of functionalized pyrimidines and imidazoles through phenacyl azides in deep eutectic solvents

We report that phenacyl azides are key compounds for a regiodivergent synthesis of valuable, functionalized imidazole (32–98% yield) and pyrimidine derivatives (45–88% yield), with a broad substrate scope, when using deep eutectic solvents [choline chloride (ChCl)/glycerol (1:2 mol/mol) and ChCl/urea (1:2 mol/mol)] as environmentally benign and non-innocent reaction media, by modulating the temperature (25 or 80 °C) in the presence or absence of bases (Et3N).

Copper-Catalyzed Synthesis of Fused Imidazopyrazine N-Oxide Skeletons

N-Propargyl-2-aroylimidazoles synthesized and converted into the corresponding ketoximes. Under various conditions, several mono- and diketoxime imidazole derivatives were formed by converting the carbonyl or carbonyl and propargyl groups into oxime groups. N -Propargyl monooxime imidazole derivatives were cyclized by treatment with CuI to give various imidazopyrazine N -oxides. Several copper salts, such as CuOAc, CuSO 4, and CuOTf, formed the same cyclization product. This cyclization reaction occurred only in the presence of Cu(I) or Cu(II) salts; other transition metals such as Au, Ag, In, and Fe did not yield cyclic products. The nucleus-independent chemical shift method was used to calculate the aromaticity of the bicyclic rings.