1094042-01-9

Basic information

• Product Name: 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanolhydrochloride
• Synonyms: 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanolhydrochloride;CYM 5442 hydrochloride;CYM 5442;2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanol;CYM 5442 HCl;CYM5442 , 1094042-01-9;Ethanol, 2-[[4-[5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]amino]-
• CAS NO: 1094042-01-9
• Molecular Formula: C₂₃H₂₇N₃O₄
• Molecular Weight: 446
• Product Categories: Inhibitors
• Mol File: 1094042-01-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 617.5±65.0 °C(Predicted)
• Appearance: /
• Density: 1.27±0.1 g/cm3(Predicted)
• Storage Temp.: Store at -20°C
• Solubility: DMSO: >5mg/mL
• PKA: 14.73±0.10(Predicted)
• CAS DataBase Reference: 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanolhydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanolhydrochloride(1094042-01-9)
• EPA Substance Registry System: 2-(4-(5-(3,4-Diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ylamino)ethanolhydrochloride(1094042-01-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1094042-01-9(Hazardous Substances Data)

Usage

Uses

CYM 5442 is an extracellular lipid mediator whose major effects are mediated by G-protein-coupled receptors. These are important for vascular development.

Biochem/physiol Actions

CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist that activates S1P1-dependent pathways in vitro and to levels of full efficacy in vivo through a hydrophobic pocket, separable from the orthosteric site of S1P binding that is headgroup dependent. This is a different site from those involved in the activities of other agonists such as FTY720 and SEW2871.

Upstream product

• 1093827-52-1 (±)-4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-ol 
• 141-43-5 ethanolamine 
• 60899-34-5 4-cyano-2,3-dihydro-1H-inden-1-one 
• 125114-76-3 (±)-1-hydroxy-2,3-dihydro-1H-indene-4-carbonitrile 
• 1093827-51-0 N',1-dihydroxy-2,3-dihydro-1H-indene-4-carboximidamide 

Relevant articles and documents

NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS

Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-1-phosphate receptor subtype 3. Uses and methods of inventive compounds