110480-86-9 Usage
Description
(1S)-1-Amino-2-methyl-1-phenylpropan-2-ol is a chiral amine compound with a unique structure featuring an amino group, a methyl group, and a phenyl group attached to a chiral carbon center. (1S)-1-Amino-2-methyl-1-phenylpropan-2-ol is characterized by its stereochemistry, which is crucial for its reactivity and applications in various chemical processes.
Uses
Used in Pharmaceutical Industry:
(1S)-1-Amino-2-methyl-1-phenylpropan-2-ol is used as a reactant/reagent for the stereoselective preparation of diaryl carbonyl compounds. This is achieved through palladium-catalyzed enantioselective redox-relay oxidative Heck arylation of arylboronic acids and homoallylic alcohols. The resulting diaryl carbonyl compounds are valuable intermediates in the synthesis of pharmaceuticals, agrochemicals, and other bioactive molecules, where the stereochemistry of the starting material can significantly influence the biological activity of the final product.
Used in Chemical Research:
In the field of chemical research, (1S)-1-Amino-2-methyl-1-phenylpropan-2-ol serves as a valuable building block for the development of new synthetic methodologies and the exploration of novel reaction mechanisms. Its unique structure and reactivity make it an attractive candidate for studying asymmetric catalysis, enantioselective reactions, and the development of new chiral ligands or catalysts.
Used in Material Science:
(1S)-1-Amino-2-methyl-1-phenylpropan-2-ol can also be utilized in the synthesis of chiral materials, such as polymers, liquid crystals, and other functional materials. The incorporation of this chiral amine into the structure of these materials can lead to unique properties, such as enhanced selectivity, improved performance, or novel applications in various industries, including electronics, sensors, and coatings.
Check Digit Verification of cas no
The CAS Registry Mumber 110480-86-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,0,4,8 and 0 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 110480-86:
(8*1)+(7*1)+(6*0)+(5*4)+(4*8)+(3*0)+(2*8)+(1*6)=89
89 % 10 = 9
So 110480-86-9 is a valid CAS Registry Number.
InChI:InChI=1S/C10H15NO/c1-10(2,12)9(11)8-6-4-3-5-7-8/h3-7,9,12H,11H2,1-2H3/t9-/m0/s1
110480-86-9Relevant articles and documents
Pd-Catalyzed Asymmetric Synthesis of 3,4-Dihydroisoquinolinones From N-Ts-Benzamides and 1,3-Dienes
Kim, Tae Kyun,Youn, So Won
, p. 521 - 524 (2021)
-
Catalytic Asymmetric Intermolecular Cyclopropanation of a Ketone Carbene Precursor by a Ruthenium(II)-Pheox Complex
Chi, Le Thi Loan,Suharto, Agus,Da, Ho Linh,Chanthamath, Soda,Shibatomi, Kazutaka,Iwasa, Seiji
, p. 951 - 955 (2019/01/25)
The diazo derivative of acetonyl acetate is a useful basic skeleton for the synthesis of cyclopropyl ketones. The intermolecular cyclopropanations of diazo acetoxy acetone with olefins are accomplished by using a novel p-nitro-Ru(II)-diphenyl-Pheox catalyst to give the corresponding optically active cyclopropane derivatives in good yields (up to 95%) with excellent diastereoselectivities (up to 99:1) and enantioselectivities (up to 98% ee). (Figure presented.).
ERK INHIBITORS
-
Page/Page column 70, (2015/07/07)
Disclosed are the ERK inhibitors of formula (1.0) and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1.0). This invention provides compounds that are ERK inhibitors (i.e., ERK2 inhibitors). This invention also provides a pharmaceutical composition comprising an effective amount of at least one (e.g., 1) compound of formula (1.0) and a pharmaceutically acceptable carrier.
