111496-58-3

Basic information

• Product Name: (S)-1-((S)-6-Benzyloxycarbonylamino-2-{[4-(4-fluoro-phenyl)-butyl]-hydroxy-phosphinoyloxy}-hexanoyl)-pyrrolidine-2-carboxylic acid benzyl ester
• Synonyms: (S)-1-((S)-6-Benzyloxycarbonylamino-2-{[4-(4-fluoro-phenyl)-butyl]-hydroxy-phosphinoyloxy}-hexanoyl)-pyrrolidine-2-carboxylic acid benzyl ester
• CAS NO: 111496-58-3
• Molecular Weight: 682.726
• Mol File: 111496-58-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-1-((S)-6-Benzyloxycarbonylamino-2-{[4-(4-fluoro-phenyl)-butyl]-hydroxy-phosphinoyloxy}-hexanoyl)-pyrrolidine-2-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-((S)-6-Benzyloxycarbonylamino-2-{[4-(4-fluoro-phenyl)-butyl]-hydroxy-phosphinoyloxy}-hexanoyl)-pyrrolidine-2-carboxylic acid benzyl ester(111496-58-3)
• EPA Substance Registry System: (S)-1-((S)-6-Benzyloxycarbonylamino-2-{[4-(4-fluoro-phenyl)-butyl]-hydroxy-phosphinoyloxy}-hexanoyl)-pyrrolidine-2-carboxylic acid benzyl ester(111496-58-3)

Safety Data

• Hazardous Substances Data: 111496-58-3(Hazardous Substances Data)

Upstream product

• 110931-32-3 1-<(S)-2-hydroxy-1-oxo-6-<<(phenylmethoxy)carbonyl>amino>hexyl>-L-proline phenylmethyl ester 
• 109635-75-8 [4-(4-fluorophenyl)butyl]phosphinic acid 
• 501-53-1 benzyl chloroformate 
• 59221-35-1 (S)-6-[[(Phenylmethoxy)carbonyl]amino]-2-hydroxyhexanoic acid 
• 42491-84-9 (S)-6-Amino-2-hydroxyhexanoic acid 
• 2248-13-7 1-(but-3-en-1-yl)-4-fluorobenzene 

Relevant articles and documents

(Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme (ACE). 1. Discovery of (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]- -proline, a novel orally active inhibitor of ACE

The synthesis of a series of orally active, phosphinyloxyacyl proline inhibitors of angiotensin converting enzyme (ACE) is described. The in vitro and in vivo ACE inhibitory activities are reported for each compound. The structure-activity relationship fo