112-49-2 Usage
Description
Triethylene glycol dimethyl ether, also known as Triglyme, is a polyether compound consisting of dodecane with oxygen atoms replacing the carbon atoms at positions 2, 5, 8, and 11. It is a water-white liquid with a mild ether odor and is characterized by its density (D 0.9862 at 20°C), refractive index (1.4233 at 20°C), flash point (232°F or 111°C), boiling points (216.0°C at 760mmHg and 153.6°C at 100mm Hg), and freezing point (-46°C). It is completely soluble in water and hydrocarbons at 20°C and may contain peroxides. Triethylene glycol dimethyl ether is combustible.
Uses
Used in Solvent Applications:
Triethylene glycol dimethyl ether is used as a solvent for gases and for coupling immiscible liquids. Its ability to dissolve in water and hydrocarbons makes it a versatile solvent in various chemical processes.
Used in Analytical Chemistry:
Triethylene glycol dimethyl ether may be used as an analytical standard for the quantification of the analyte in water samples. It is employed in in vitro bioassays and chemical screening techniques to ensure accurate measurements and analysis.
Used in Perfluoro-triethyleneglycoldimethylether Preparation:
Triethylene glycol dimethyl ether is also used in the preparation of perfluoro-triethyleneglycoldimethylether, a compound with specific properties and applications in various industries.
Used in Labelled Triglyme:
Labelled Triglyme, a variant of triethylene glycol dimethyl ether, is used as a solvent in specific applications where its unique properties are required.
Reactivity Profile
TRIETHYLENE GLYCOL DIMETHYL ETHER forms explosive peroxides on prolonged exposure to air. Its decomposition products may be sensitive to shock. The bulk chemical is stable for 2 weeks at temperatures up to 140° F when protected from light. TRIETHYLENE GLYCOL DIMETHYL ETHER is incompatible with strong oxidizers. TRIETHYLENE GLYCOL DIMETHYL ETHER is also incompatible with strong acids. TRIETHYLENE GLYCOL DIMETHYL ETHER may react with peroxides, oxygen, nitric acid and sulfuric acid. .
Flammability and Explosibility
Nonflammable
Purification Methods
Reflux it with, and distil it from sodium hydride or LiAlH4. [Beilstein 1 IV 2401.]
Check Digit Verification of cas no
The CAS Registry Mumber 112-49-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 2 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 112-49:
(5*1)+(4*1)+(3*2)+(2*4)+(1*9)=32
32 % 10 = 2
So 112-49-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H18O4/c1-8(11-6-4-9-2)12-7-5-10-3/h8H,4-7H2,1-3H3
112-49-2Relevant articles and documents
Cleavage of different ether bonds in butyl glycidyl ether and allyl glycidyl ether by K-, K+ (15-crown-5)2
Grobelny, Zbigniew,Stolarzewicz, Andrzej,Maercker, Adalbert,Krompiec, Stanis?aw,Bieg, Tadeusz
, p. 133 - 138 (2002)
The kind of substituent in alkyl glycidyl ethers affects the course of their reaction with K1, K+ (15-crown-5)2. The cyclic oxirane ring is exclusively cleaved in the case of butyl glycidyl ether whereas the presence of the unsaturated allyl group in the glycidyl ether molecule unexpectedly prefers the scission of the linear ether bond. In both the systems organometallic intermediates are formed. They react with crown ether causing its ring opening. Allylpotassium formed from allyl glycidyl ether reacts also with another glycidyl ether molecule; the oxirane ring is opened in this case.
Synthesis, characterization and spectroscopic properties of water soluble coumarins substituted with oligomeric alkoxy functions
Surya Prakash Rao,Babu, Mohan,Desai, Avinash
, p. 11064 - 11072 (2014/03/21)
Novel water soluble robust fluorescent coumarins substituted with oligomeric alkoxy functions were synthesized by incorporating the Blaise reaction in the key step. Mono-methylated oligomeric polyethylene glycols were subjected to a three step protocol, namely (i) Michael addition to acrylonitrile, (ii) Blaise reaction with ethyl bromoacetate and (iii) condensation with 4-N,N-diethylamino-2-hydroxybenzaldehyde to give fluorescent water soluble coumarins. Water solubility of the coumarins increased with the number of oxygen atoms in the side chain. However, even the most water soluble coumarin in this series can be readily extracted out of water with organic solvents like dichloromethane or ethyl acetate. Both absorption and emission spectra, recorded in four solvents, namely, hexane (non-polar), ethyl acetate (moderately polar), methanol (polar protic) and water (highly polar and protic) displayed a bathochromic shift of the absorption (Δλmax ≈ 25 nm) and emission (Δλmax ≈ 57 nm) bands with increasing solvent polarity. The Δλmax of emission is more pronounced than the Δλmax of absorption, which indicates intramolecular charge-transfer (ICT) is less in the ground state compared to the excited state. Emission spectra recorded in these four solvents showed that fluorescent intensity is maximum in ethyl acetate.
Continuous process for the preparation of alkylene glycol diethers
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Page/Page column 3, (2008/06/13)
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