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72593-77-2

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72593-77-2 Usage

Description

Diethylene Glycol 2-Bromoethyl Methyl Ether is an organic compound that features a PEG (polyethylene glycol) linker with a bromoethyl methyl ether functional group. The presence of the bromide atom makes it a suitable candidate for nucleophilic substitution reactions, while the hydrophilic PEG spacer enhances its solubility in aqueous environments.

Uses

Used in Pharmaceutical Industry:
Diethylene Glycol 2-Bromoethyl Methyl Ether is used as a building block or intermediate in the synthesis of pharmaceutical compounds. Its reactivity in nucleophilic substitution reactions allows for the attachment of various functional groups, which can be utilized to create new drug molecules with specific therapeutic properties.
Used in Chemical Synthesis:
In the field of chemical synthesis, Diethylene Glycol 2-Bromoethyl Methyl Ether is used as a versatile reagent for the preparation of a wide range of organic compounds. Its ability to undergo nucleophilic substitution reactions makes it a valuable component in the synthesis of complex organic molecules, including those with potential applications in materials science, agrochemicals, and other industries.
Used in Bioconjugation:
Diethylene Glycol 2-Bromoethyl Methyl Ether is used as a bioconjugation agent for the attachment of biologically active molecules, such as peptides, proteins, or nucleic acids, to other molecules or surfaces. The hydrophilic PEG spacer can help to improve the stability and solubility of the resulting conjugates, while the bromoethyl methyl ether group provides a reactive handle for the attachment of the biomolecule.
Used in Drug Delivery Systems:
In drug delivery applications, Diethylene Glycol 2-Bromoethyl Methyl Ether can be used to modify drug molecules or drug delivery vehicles, such as nanoparticles or liposomes, to improve their solubility, stability, or targeting properties. The PEG spacer can also help to reduce the immunogenicity or non-specific interactions of the drug delivery system, potentially enhancing its therapeutic efficacy and safety.

Check Digit Verification of cas no

The CAS Registry Mumber 72593-77-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,5,9 and 3 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 72593-77:
(7*7)+(6*2)+(5*5)+(4*9)+(3*3)+(2*7)+(1*7)=152
152 % 10 = 2
So 72593-77-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H15BrO3/c1-9-4-5-11-7-6-10-3-2-8/h2-7H2,1H3

72593-77-2 Well-known Company Product Price

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  • TCI America

  • (D3831)  Diethylene Glycol 2-Bromoethyl Methyl Ether  >94.0%(GC)

  • 72593-77-2

  • 5g

  • 1,460.00CNY

  • Detail
  • TCI America

  • (D3831)  Diethylene Glycol 2-Bromoethyl Methyl Ether  >94.0%(GC)

  • 72593-77-2

  • 25g

  • 4,750.00CNY

  • Detail
  • Aldrich

  • (791865)  1-(2-Bromoethoxy)-2-(2-methoxyethoxy)ethane  97%

  • 72593-77-2

  • 791865-5G

  • 2,061.54CNY

  • Detail
  • Aldrich

  • (791865)  1-(2-Bromoethoxy)-2-(2-methoxyethoxy)ethane  97%

  • 72593-77-2

  • 791865-25G

  • 8,137.35CNY

  • Detail

72593-77-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Diethylene Glycol 2-Bromoethyl Methyl Ether

1.2 Other means of identification

Product number -
Other names 1-[2-(2-bromoethoxy)ethoxy]-2-methoxyethane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:72593-77-2 SDS

72593-77-2Relevant articles and documents

The discovery and enhanced properties of trichain lipids in lipopolyplex gene delivery systems

Mohammadi, Atefeh,Kudsiova, Laila,Mustapa, M. Firouz Mohd,Campbell, Frederick,Vlaho, Danielle,Welser, Katharina,Story, Harriet,Tagalakis, Aristides D.,Hart, Stephen L.,Barlow, David J.,Tabor, Alethea B.,Lawrence, M. Jayne,Hailes, Helen C.

, p. 945 - 957 (2019)

The formation of a novel trichain (TC) lipid was discovered when a cationic lipid possessing a terminal hydroxyl group and the helper lipid dioleoyl l-α-phosphatidylethanolamine (DOPE) were formulated as vesicles and stored. Importantly, the transfection efficacies of lipopolyplexes comprised of the TC lipid, a targeting peptide and DNA (LPDs) were found to be higher than when the corresponding dichain (DC) lipid was used. To explore this interesting discovery and determine if this concept can be more generally applied to improve gene delivery efficiencies, the design and synthesis of a series of novel TC cationic lipids and the corresponding DC lipids was undertaken. Transfection efficacies of the LPDs were found to be higher when using the TC lipids compared to the DC analogues, so experiments were carried out to investigate the reasons for this enhancement. Sizing experiments and transmission electron microscopy indicated that there were no major differences in the size and shape of the LPDs prepared using the TC and DC lipids, while circular dichroism spectroscopy showed that the presence of the third acyl chain did not influence the conformation of the DNA within the LPD. In contrast, small angle neutron scattering studies showed a considerable re-arrangement of lipid conformation upon formulation as LPDs, particularly of the TC lipids, while gel electrophoresis studies revealed that the use of a TC lipid in the LPD formulation resulted in enhanced DNA protection properties. Thus, the major enhancement in transfection performance of these novel TC lipids can be attributed to their ability to protect and subsequently release DNA. Importantly, the TC lipids described here highlight a valuable structural template for the generation of gene delivery vectors, based on the use of lipids with three hydrophobic chains.

Fong et al.

, p. 857,858,859 (1977)

Synthesis of Phosphonic Acid Ligands for Nanocrystal Surface Functionalization and Solution Processed Memristors

De Roo, Jonathan,Zhou, Zimu,Wang, Jiaying,Deblock, Loren,Crosby, Alfred J.,Owen, Jonathan S.,Nonnenmann, Stephen S.

, p. 8034 - 8039 (2018/10/25)

Here, we synthesized 2-ethylhexyl, 2-hexyldecyl, 2-[2-(2-methoxyethoxy)ethoxy]ethyl, oleyl, and n-octadecyl phosphonic acid and used them to functionalize CdSe and HfO2 nanocrystals. In contrast to branched carboxylic acids, postsynthetic surface functionalization of CdSe and HfO2 nanocrystals was readily achieved with branched phosphonic acids. Phosphonic acid capped HfO2 nanocrystals were subsequently evaluated as memristors using conductive atomic force microscopy. We found that 2-ethylhexyl phosphonic acid is a superior ligand, combining a high colloidal stability with a compact ligand shell that results in a record-low operating voltage that is promising for application in flexible electronics.

Glycol-functionalized ionic liquids for high-temperature enzymatic ring-opening polymerization

Zhao, Hua,Afriyie, Lennox O.,Larm, Nathaniel E.,Baker, Gary A.

, p. 36025 - 36033 (2018/11/20)

Enzymatic ring-opening polymerization (ROP) is a benign method for preparing polyesters, such as polylactides and other polylactones. These reactions are typically carried out at relatively high temperatures (60-130 °C), however, there is a deficiency of enzyme-compatible solvents for such thermally-demanding biocatalytic processes. In this study, we have prepared a series of short-chained glycol-grafted ionic liquids (ILs) based on a phosphonium, imidazolium, pyridinium, ammonium, or piperidinium cationic headgroup. Most of these glycol-grafted ILs exhibit relatively low dynamic viscosities (33-123 mPa s at 30 °C), coupled with excellent short-term thermal stabilities with decomposition temperatures (Tdcp) in the 318-403 °C range. Significantly, the long-term thermal stability under conditions matching those for enzymatic ROP synthesis (130 °C for 7 days) is excellent for several of these task-specific ILs. Using Novozym 435-catalyzed ROP, these ILs are demonstrated to be viable solvents for the enzymatic production of reasonable yields (30-48%) of high molecular mass (Mw ~20 kDa) poly(l-lactide) and poly(?-caprolactone) compared to solventless conditions (12-14 kDa).

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