112157-30-9

Basic information

• Product Name: Carbamic acid, [3-methyl-1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]butyl]-, 1,1-dimethylethyl ester, (S)-
• CAS NO: 112157-30-9
• Molecular Formula: C18H29NO5S
• Molecular Weight: 371.498
• Mol File: 112157-30-9.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [3-methyl-1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]butyl]-, 1,1-dimethylethyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [3-methyl-1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]butyl]-, 1,1-dimethylethyl ester, (S)-(112157-30-9)
• EPA Substance Registry System: Carbamic acid, [3-methyl-1-[[[(4-methylphenyl)sulfonyl]oxy]methyl]butyl]-, 1,1-dimethylethyl ester, (S)-(112157-30-9)

Safety Data

• Hazardous Substances Data: 112157-30-9(Hazardous Substances Data)

Upstream product

• 61-90-5 L-leucine 
• 63096-02-6 N-tert-butoxycarbonyl-L-leucine methyl ester 
• 2666-93-5 (S)-Leu-OMe 
• 24424-99-5 di-tert-butyl dicarbonate 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 82010-31-9 (S)-(1-hydroxymethyl-3-methylbutyl)carbamic acid tert-butyl ester 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1185454-00-5 C₁₂H₁₈BrNS 
• 1185453-88-6 C₁₇H₂₆BrNO₂S 
• 112383-35-4 Leu-Ψ(CH2S)-Ala-Aznva-OCH2Ph hydrochloride 
• 112383-10-5 N-<(1S)-(1-methoxycarbonyl-3-methylbutyl)carbamoyl>-L-leucyl-Ψ(CH2S)-L-alanyl-α-azanorvaline benzyl ester 
• 112383-34-3 N-t-butoxycarbonyl-L-leucyl-Ψ(CH2S)-L-alanyl-α-azanorvaline benzyl ester 
• 112157-36-5 (S)-2-Amino-N-{(S)-1-[(S)-2-((S)-2-amino-3-phenyl-propionylamino)-4-methyl-pentyldisulfanylmethyl]-3-methyl-butyl}-3-phenyl-propionamide; compound with trifluoro-acetic acid 
• 112157-34-3 ((S)-1-{(S)-1-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentyldisulfanylmethyl]-3-methyl-butylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester 
• 112157-33-2 (H-Leu(CH₂S)-)2*2HCl 
• 215608-35-8 methyl (S)-4-<(benzyloxycarbonyl)amino>-6-methyl-2-oxoheptanoate 
• 118247-68-0 N-Benzyloxycarbonyl-L-Homoleucine 
• 22818-43-5 (S)-3-amino-5-methylhexanoic acid 
• 354988-10-6 (5S)-7-methyl-5-[N-(2-nitrophenylsulfonyl)amino]octa-1,2-diene 

Relevant articles and documents

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To discover broad spectrum antifungal agents, two strategies were applied, and a novel class of L-amino alcohol derivatives were designed and synthesized. 3-F substituted compounds 14i, 14n, 14s and 14v exhibited excellent antifungal activities with broad antifungal spectra against C. albicans and C. tropicalis, with MIC values in the range of 0.03–0.06 μg/mL, and against A. fumigatus and C. neoformans, with MIC values in the range of 1–2 μg/mL. Notably, Compounds 14i, 14n, 14s and 14v also displayed moderate activities against fluconazole-resistance strains 17# and CaR that were isolated from AIDS patients. Moreover, only compounds in the S-configuration showed antifungal activity. Preliminary mechanistic studies showed that the potent antifungal activity of compound 14v stemmed from inhibition of C. albicans CYP51. Compounds 14n and 14v were almost nontoxic to mammalian A549 cells, and their stability in human plasma was excellent.

BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES AS APJ RECEPTOR MODULATORS

The present invention relates to benzoimidazole-carboxylic acid amide compounds of the formula I, in which R', R", R"', R1, R2, R3, R4, R5, R6 and Z are defined as indicated below. The comp